I would think you would need to start researching what varieties would grow best in your particular climate zone. Finding out your areas growing seasons length, soil requirements, amendments, amount of sun needed, ( full sun is at least 8 hours per day ) pest concerns etc. I love the look of tobacco plants, they are impressive all on their own aside from harvesting them for smoking purposes. I would also think you would need to plant a large plot of plants, maybe a half acre or so, minimum, to get the yield you desire if you want to have a long lasting supply on hand.