Description : Non steroidal anti inflammatory drugs, such as aspirin act by inhibiting the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipase A2 (D) Lipoprotein lipase
Last Answer : Answer : B
Description : Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions? (a) Phospholipase (b) Lipoxygenase (c) Cyclooxygenase-I (d) Cyclooxygenase II (e) Xanthine oxidase
Last Answer : Ans: D
Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase
Last Answer : C. Phospholipase-A
Description : Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) ... 2 (c) Glutathione - S - transferase (d) Lipoxygenase (e) Phospholipase A2
Last Answer : Ans: B
Description : Aspirin inhibits the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipae A1 (D) Phospholipase A2
Description : The action of aspirin that results in its greater efficacy as an antithrombotic (anti-platelet) drug is its ability to (a) Inhibit lipoxygenase as well as cyclooxygenase (b) Selectively inhibit ... I (c) Inhibit leukocyte migration (d) Promote uric acid excretion (e) Acetylate cyclooxygenase
Last Answer : Ans: E
Description : Corticosteroids exert anti-inflammatory action by inhibiting the following enzyme (a) Cycloxygenase (b) Lipozygenase (c) Phospholipase - A (d) Phosphodiesterase
Last Answer : Ans: C
Description : From arachidonate, synthesis of prostaglandins is catalysed by (A) Cyclooxygenase (B) Lipoxygenase (C) Thromboxane synthase (D) Isomerase
Last Answer : Answer : A
Description : Anti-inflammatory corticosteroids inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase
Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam
Last Answer : Ans: A
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible
Description : Which of the following is a reversible inhibitor of platelet cyclooxygenase? (a) Alprostadil (b) Aspirin (c) Ibuprofen (d) LTC4 (e) Misoprostol
Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above
Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition
Description : Select the drug which inhibits cyclooxygenase irreversibly: A. Aspirin B. Mephenamic acid C. Naproxen D. Diclofenac
Last Answer : A. Aspirin
Description : Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible
Last Answer : B. Platelets cannot synthesize fresh COX molecules
Description : Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely
Last Answer : D. COX-1 is constitutive while COX-2 is largely
Description : Which of the following immune responses is responsible for rejection of kidney graft? (a) Cell-mediated immune response (b) Auto-immune response (c) Humoral immune response (d) Inflammatory immune response
Last Answer : (a) Cell-mediated immune response
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid
Last Answer : B
Description : Aspirin prolongs bleeding time by inhibiting the synthesis of: A. Clotting factors in liver B. Prostacyclin in vascular endothelium C. Cyclic AMP in platelets D. Thromboxane A2 in platelets
Last Answer : D. Thromboxane A2 in platelets
Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin
Last Answer : A. Thromboxane
Last Answer : (B) Allopurinol
Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is (a) Acid – base and electrolytc disturbances (b) Hypersensitivity and idiosyncratic reactions (c) Gastric mucosal damage (d) Salicylism
Description : All of the following medications should not be used routinely in pregnant patients during the third trimester except (a) Acetaminophen (b) Nonsteroidal anti-inflammatory drugs (c) Warfarin (d) Lithium (e) Aspirin
Description : A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side ... appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam
Description : Of the following classifications of medications, which is known to inhibit prostaglandin synthesis or release? a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs ... to cause immunosuppression. d) Antineoplastic agents Antineoplastic agents are known to cause immunosuppression.
Last Answer : a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs include aspirin and ibuprofen.
Description : By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway.
Last Answer : B. It blocks the cyclo-oxygenase pathway.
Description : Morphine analgesia differs from that produced by aspirin in the following respect(s): A. It has a higher ceiling B. It covers both perception as well as psychic processing of the pain C. Visceral and ischaemic pain is relieved better than somatic inflammatory pain D. All of the above are correct
Last Answer : D. All of the above are correct
Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is: A. Acid-base and electrolyte disturbances B. Hypersensitivity and idiosyncratic reactions C. Gastric mucosal damage D. Salicylism
Last Answer : C. Gastric mucosal damage
Description : Regulator gene controls chemical synthesis (Operon concept) by (a) Inhibiting transcription of mRNA (b) Inhibiting enzymes (c) Inhibiting passage of mRNA (d) Inhibiting substrate enzyme reaction
Last Answer : Ans. ((a))
Description : The most important mechanism of antiinflammatory action of glucocorticoids is: A. Inhibition of lysosomal enzymes B. Restriction of recruitment of inflammatory cells at the site of inflammation C. Antagonism of action of interleukins D. Suppression of complement function
Last Answer : B. Restriction of recruitment of inflammatory cells at the site of inflammation
Description : The primary objective for designing drugs that selectively inhibit COX - 2 is to (a) Decrease the risk of nephrotoxicity (b) Improve anti-inflammatory effectiveness (c) Lower the ... of treatment of rheumatoid arthritis (e) Selectively decrease thromboxane A2 without effects on other eicosanoids
Description : Which of the following regarding thromboxane A2 is true? C A. It degrades basement membranes B. It is produced via the lipoxygenase pathway C. It stimulates platelet aggregation D. None of these
Last Answer : It stimulates platelet aggregation
Description : The following eicosanoid is generated through the lipoxygenase pathway: A. Prostaglandin E2 B. Thromboxane A2 C. Leukotriene C4 D. Prostacyclin
Last Answer : C. Leukotriene C4
Description : A man has an Escherichia coli bacteremia with a low-grade fever (101.6°F). Appropriate management of his fever would be (a) Give acetaminophen 650 mg orally every 4 hours (b) Give aspirin 650 ... fever curve to monitor his response to antibiotic therapy (e) Use tepid water baths to reduce the fever
Description : Which of the following medications are used to reverse the effects of heparin? a) Protamine sulfate Protamine sulfate is known as the antagonist to heparin. b) Streptokinase Streptokinase is a ... placement. d) Aspirin The antiplatelet effect of aspirin does not reverse the effects of heparin.
Last Answer : a) Protamine sulfate Protamine sulfate is known as the antagonist to heparin.
Description : Leukotrienes: 1) Are formed from the cyclooxygenase pathway 2) Are synthesized by fibroblasts 3) Decrease vascular permeability 4) Leukotriene D4 has been identified as SRS-A which causes bronchial wall smooth muscle relaxation 5) Stimulate mucus secretion
Last Answer : Answers-5 Leukotrienes are synthesized by leucocytes.They are mediators of allergic reaction. They increase vascular permeability and attract neutrophils and eosinophils to inflammatory sites. ... stimulate mucus production, an important consideration in the pathophysiology of bronchial asthma.
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues
Description : Cyclooxygenase-1 and –2 are responsible for (a) The synthesis of prostaglandins from arachidonate (b) The synthesis of leukotrienes from arachidonate (c) The conversion of ATP to cAMP (d) The metabolic degradation of cAMP (e) The conversion of GTP to cGMP
Description : Select the drug which inhibits cyclooxygenase in the brain but not at peripheral sites of inflammation: A. Nimesulide B. Paracetamol C. Ketorolac D. Mephenamic acid
Last Answer : B. Paracetamol
Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen
Last Answer : B. Meloxicam
Description : The isoenzyme cyclooxygenase-2 (COX-2) is expressed constitutively at the following site: A. Gastric mucosa B. Neutrophils C. Blood platelets D. Juxtaglomerular apparatus
Last Answer : D. Juxtaglomerular apparatus
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues
Last Answer : B. It is inducible
Description : Visual-evoked response: a. is used primarily to detect visual loss due to retinal disease b. produces biphasic wavefronts c. may give falsely delayed latency if the patient is not concentrating d. produces responses in normal subjects with a latency of 100msec
Last Answer : produces responses in normal subjects with a latency of 100msec
Description : Phospholipase C is activated by (A) Gs proteins (B) Gi proteins (C) Gq proteins (D) G12 proteins
Last Answer : Answer : C
Description : Activated phospholipase C acts on (A) Phosphatidyl inositol-4, 5-biphosphate (B) Inositol-1, 4, 5-triphosphate (C) Protein kinase C (D) Pl-3 kinase
Description : Binding of insulin to its receptor activates (A) Adenylate cyclase (B) Guanylate cyclase (C) Phospholipase C (D) Tyrosine kinase
Last Answer : Answer : D
Description : Some hormones produce their intracellular effects by activating (A) Phospholipae A1 (B) Phospholipase B (C) Phospholipase C (D) All of these