Which one of the following is a feature of the VIPoma syndrome? 1) Alkalosis 2) Hypoglycaemia 3) Hypokalaemia 4) Increased gastric acid seceretion 5) Provocation of VIP release by somatostatin

Which one of the following is a feature of the VIPoma syndrome? 1) Alkalosis 2) Hypoglycaemia 3) Hypokalaemia 4) Increased gastric acid seceretion 5) Provocation of VIP release by somatostatin
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Answers-3  a, b,d,e: All opposite to what is expected. VIPOMA -Features vasoactive intestinal polypeptide secreting tumour, mainly pancreas rarely ganglioneuroblatoma (sympathetic chain or adrenal cortex), secretory diarrhoea ('pancreatic cholera'), weight loss, dehydration, abdominal colic, cutaneous flushing, raised plasma VIP, urea+Calcium, raised plasma pancreatic polypeptide, hypokalaemic acidosis (loss of alkaline secretions), achlorydia, mildly raised glucose, normal functions of VIP. - increased intestinal secretion water and electrolytes -peripheral vasodilation - inhibits gastric acid secretion -potentiates acetylcholine action on salivary glands
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