Serum biochemistry of a 60 year old man revealed calcium of 1.98 mmol/l and phosphate of 0.55 mmol/l with an alkaline phosphatase of 450 IU/l.Which among the following mosts suits with the above serum biochemistry? 1) Osteoporosis 2) Osteomalacia 3) Pagets Disease 4) Secondary Hyperparathyroidism 5) Renal failure

Serum biochemistry of a 60 year old man revealed calcium of 1.98 mmol/l and phosphate of 0.55 mmol/l with an alkaline phosphatase of 450 IU/l.Which among the following mosts suits with the above serum biochemistry? 1) Osteoporosis 2) Osteomalacia 3) Pagets Disease 4) Secondary Hyperparathyroidism 5) Renal failure
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Answers-2 Osteomalacia is associated with low calcium and phosphate with raised alkaline phosphatase. Serum biochemistry is normal in osteoporosis. Pagets disease is associated with normal calcium and phosphate with raised alkaline phosphatase. In renal failure when tertiary hyperparathyroidism sets in there is low calcium with raised phosphate.
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A 55 year-old female complaining of vague tiredness is found to have a serum corrected calcium concentration of 2.9 mmol/l. Examination was unremarkable. Which of the following results confirms the suspected diagnosis of primary hyperparathyroidism? 1) High normal 1,25-dihydroxyvitamin D concentration 2) High normal 24 hour urinary calcium concentration 3) High normal plasma parathyroid hormone concentration 4) Low normal plasma phosphate concentration 5) Low normal serum 25-hydroxyvitamin D concentration

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Last Answer : Answers-3 Bit too easy really. A high or even normal PTH concentration in the presence of hypercalcaemia would support the diagnosis of hyperparathyroidism. A high urinary Calcium concentration may ... but neither confirm the diagnosis. Elevated 1,25 VitD suggests a diagnosis of hypervitaminosis D.

A 19 year-old female is referred following a visit to the dentist where marked erosion of her teeth was noted. She was entirely asymptomatic and her only medication was the oral contraceptive pill. On examination her blood pressure was 110/70 mmHg and her body mass index was 21.5 kg/m2 (18 - 25). Investigations sodium 135 mmol/l potassium 2.1 mmol/l bicarbonate 42 mmol/l urea 2.6 mol/L corrected calcium 2.08 mmol/ alkaline phosphatase 201 iu/l (50-110) What is the most likely diagnosis? 1) Bulimia nervosa 2) Conn's syndrome 3) Laxative abuse 4) Pregnancy 5) Primary hypoparathyroidism

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Last Answer : Answer : C

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Last Answer : Answer : B

The absence of lamina dura in radiographs is a feature of all of these except for:** A. Paget’s disease (hyperphosphatasia) B. Hyperparathyroidism C. Fibrous dysplasia (como querubinismo) D. Osteogenesis imperfecta E. Hyperthyroidism

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Last Answer : Answer : B

All the following statements about obstructive jaundice are true except (A) Conjugated bilirubin in serum is normal (B) Total bilirubin in serum is raised (C) Bile salts are present in urine (D) Serum alkaline phosphatase is raised

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Last Answer : Answer : C

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The normal GPT activity ranges from (A) 60.0–250.0 IU/L (B) 4.0–17.0 IU/L (C) 3.0–15.0 IU/L (D) 0.1–14.0 IU/L

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Serum inorganic phosphorous rises in all the following conditions except (A) Hypoparathyroidism (B) Hypervitaminosis D (C) Chronic renal failure (D) After a carbohydrate-rich meal MINERAL METABOLISM 197

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The concentration of ketone bodies in the blood does not normally exceed (A) 0.2 mmol/L (B) 0.4 mmol/L (C) 1 mmol/L (D) 2 mmol/L

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