A 55 year-old female complaining of vague tiredness is found to have a serum corrected calcium concentration of 2.9 mmol/l. Examination was unremarkable. Which of the following results confirms the suspected diagnosis of primary hyperparathyroidism? 1) High normal 1,25-dihydroxyvitamin D concentration 2) High normal 24 hour urinary calcium concentration 3) High normal plasma parathyroid hormone concentration 4) Low normal plasma phosphate concentration 5) Low normal serum 25-hydroxyvitamin D concentration

A 55 year-old female complaining of vague tiredness is found to have a serum corrected calcium concentration of 2.9 mmol/l. Examination was unremarkable. Which of the following results confirms the suspected diagnosis of primary hyperparathyroidism? 1) High normal 1,25-dihydroxyvitamin D concentration 2) High normal 24 hour urinary calcium concentration 3) High normal plasma parathyroid hormone concentration 4) Low normal plasma phosphate concentration 5) Low normal serum 25-hydroxyvitamin D concentration
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Answers-3 Bit too easy really. A high or even normal PTH concentration in the presence of hypercalcaemia would support the diagnosis of hyperparathyroidism. A high urinary Calcium concentration may be expected as would a low plasma phosphate but neither confirm the diagnosis. Elevated 1,25 VitD suggests a diagnosis of hypervitaminosis D.
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A 75 year old man presents with a long history of shortness of breath and ankle oedema. His serum biochemistry shows sodium 122 mmols/l and potassium of 2.9 mmols/l. He now complains of weakness.Which of the following is likely to explain the above biochemical picture? 1) Addison's Disease 2) Nephrotic syndrome 3) Primary hyperaldosteronism 4) SIADH 5) Diuretic therapy

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18 years old female weighting 52Kg and 163cm tall. On dental examination erosion of teeth on the most of her lingual surfaces is clearly showing. Dietary history revealed a daily rate of 5000 to 7000 Kcal/day. What is the most probable diagnosis? A. Alcoholism B. Drug abuse C. Bulimia D. Excessive smoking E. Diabetic mellitus type I

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Last Answer : Answer : B

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Which of the following features would be expected on lipid analysis in a 57 year old female with two year history of primary biliary cirrhosis? 1) A lipaemic appearance of the serum would be expected. 2) is treated with clofibrate therapy 3) is characteristically associated with tendon xanthomas 4) is characteristically associated with palmar xanthomas 5) No evidence of a dyslipidaemia would be expected with this short a duration of disease

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Hydroxylation of 25-hydroxy cholecalciferol is promoted by (A) Cytochrome - a (B) Parathyroid hormone (C) Cytochrome-b (D) CAMP

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The normal serum concentration of ceruloplasmin in mg/100 ml varies between (A) 5–10 (B) 10–20 (C) 25–43 (D) 50–100

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Last Answer : Answer : C

The normal serum concentration of 1,25- dihydroxycholecalciferol in pg/ml is (A) 26–65 (B) 1–5 (C) 5–20 (D) 80–100

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Last Answer : Answer : A

The normal concentration of vitamin A in blood in I.V/dl: (A) 20–55 (B) 24–60 (C) 30–65 (D) 35–70

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Last Answer : Answer : B

Deuterium oxide and inulin are injected into a normal 30-year-old man. The volume of distribution of deuterium oxide is found to be 42 L and that of inulin 14 L. a. The man’s intracellular fluid volume is about 14 L. b. The man’s intracellular fluid volume is about 28 L. c. The man’s plasma volume is about 7 L. d. The man’s interstitial fluid volume is about 9 L. e. The man’s total body water cannot be calculated from these data

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