A 53-year-old man presented with hypertension of 150/110 mmHg. He is generally asymptomatic and has no previous medical history of note. He is a smoker of 5 cigarettes daily and drinks modest quantities of alcohol. He takes no prescribed medications. Examination reveals a BMI of 33.5 kg/2 but nil else. The following detail his investigations: Serum sodium 146 mmol/l (NR 133-145) Serum potassium 3.2 mmol/l (NR 3.5 - 5) Urinary potassium excretion 42 mmol/l (NR less than 30) What is the likely diagnosis? 1) Adrenocortical adenoma 2) Bartter's syndrome 3) Liddle's syndrome 4) Liquorice ingestion 5) Pheochromocytoma

1 Answer

Answer :

Answers-1 This patient is most likely to have Conn's syndrome as reflected by the hypokalaemic hypertension. Liquorice ingestion or Liddle's syndrome are again possible causes of hypokalaemic hypertension but the question asks for the most likely cause. This is Conn's and is most often caused by an adrenocortical adenoma. Aldosterone promotes active sodium transport and excretion of potassium in the renal tubules (and also sweat glands, salivary glands and colon). "Clinically, [Primary hyperaldosteronism] Conn's syndrome is characterized by hypertension (often diastolic hypertension), muscular weakness, paresthesias, headache, polyuria, and polydipsia."

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