Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome

Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome
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Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome - bilirubin can't Go in to the hepatocyte - unconjugated bilirubinaemia. Crigler-Najjar syndrome - bilirubin can't Conjugate - unconjugated bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
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