Description : ‘Fight or flight’ state can be described as (a) Sympathetic active; para-sympathetic quiescent (b) Sympathetic active; para-sympathetic active (c) Sympathetic quiescent; para-sympathetic active
Last Answer : Ans: A
Description : Choose the incorrect statement from the following (a) Sympathetic system increases rate of SA node (b) Sympathetic system causes constriction of coronary arteries (c) Sympathetic system causes increased motility of GIT smooth muscles (d) Sympathetic system causes constriction of sphincter in GIT
Last Answer : Ans: C
Description : In male sex organs _______ system is responsible for erection. (a) Sympathetic (b) Parasympathetic (c) Norepinephrine (d) None of the above
Last Answer : Ans: B
Description : Full activation of the sympathetic nervous system, as in maximal exercise, can produce all of the following responses except (a) Bronchial relaxation (b) Decreases intestinal motility (c) Increased renal blood flow (d) Mydriasis (e) Increased heart rate (tachycardia)
Description : In the autonomic regulation of blood pressure (a) Cardiac output is maintained constant at the expense of other hemodynamic variables (b) Elevation of blood pressure results in elevated ... the sensitivity of the sensory baroreceptor nerve endings might cause an increase in sympathetic discharge
Last Answer : Ans: D
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Description : At rest, the interior of the typical mammalian neuronal axon potential is approximately ________ mV (a) 0 (b) –70 (c) –100 (d) –20
Description : Prazosin is an effective antihypertensive while nonselective a adrenergic blockers are not because (a) It is the only orally active a blocker (b) It improves plasma lipid profile (c) It does not concurrently enhance noradrenaline release (d) It improves urine flow in males with prostatic hypertrophy
Description : Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine
Last Answer : Ans: E
Description : Give an example to show that sympathetic and para-sympathetic system work opposite in function.
Last Answer : Sympathetic system stimulates the pupil in the eye to dilate (open) where as parasympathetic system stimulates it to constrict (close).
Description : By which nervous system and of what type, the blood is supplied into visceral organs? (a) Both SNS and PNS, involuntary (b) Para-sympathetic nervous system involuntary (c) Sympathetic nervous system, involuntary (d) Sympathetic nervous system, voluntary
Last Answer : (a) Both SNS and PNS, involuntary
Description : Phenylephrine (a) Mimics the transmitter at post-synaptic receptors (b) Displaces transmitter from axonal terminal (c) Inhibits synthesis of transmitter (d) None of the above
Description : Propranolol does not block the following action of adrenaline (a) Bronchodilation (b) Lipolysis (c) Muscle tremor (d) Mydriasis
Description : Propanolol can be used to allay anxiety associated with (a) Chronic neurotic disorer (b) Schizopherenia (c) Short-term stressful situation (d) Endogenous depression
Description : The ß-adrenergic blocker which possesses both ß1 selectivity as well as intrinsic sympathomimetic activity is (a) Alprenolol (b) Atenolol (c) Acebutolol (d) Metoprolol
Description : Which of the following is true of sildenafil (a) It enhances sexul enjoyment in normal men (b) It delays ejaculation (c) It is indicated only for treatment of erectile dysfunction in men (d) It blocks cavernosal a2 adrenoceptors
Description : The drug which produces vasoconstriction despite being an a adrenergic blocker is (a) Phenoxybenzamine (b) Ergotamine (c) Dihydroergotoxine (d) Tolazoline
Description : Guanethidine inhibits (a) Synthesis of transmitter (b) Metabolism of transmitter (c) Release of transmitter (d) Displacement of transmitter from axonal terminal
Description : Vasoconstrictors should not be used in (a) Neurogenic shock (b) Haemorrhagic shock (c) Secondary shock (d) Hypotension due to spinal anaesthesia
Description : While undergoing a surgical procedure a patient develops hypotension. Which of the following drugs can be injected intramuscularly to raise his BP (a) Noradrenaline (b) Isoprenaline (c) Mephentermine (d) Isoxsuprine
Description : Continuous exposure of ctecholaminesensitive cells and tissues to adrenergic agonists causes a progressive diminition in their capacity to respond, this phenomenon is called as (a) Refractoriness (b) Desensitization (c) Tachyphylaxis (d) All of the above
Description : Ephedrine is similar to adrenaline in the following feature (a) Potency (b) Inability to penetrate blood-brain barrier (c) Duration of action (d) Producing both a and ß adrenergic effects
Description : Dobutamine differs from dopamine in that (a) It does not activate peripheral dopaminergic receptors (b) It does not activate adrenergic ß receptors (c) It causes pronounced tachycardia (d) It has good blood-brain barrier penetrability
Description : Noradrenaline is administered by (a) Subcutaneous injection (b) Intramuscular injection (c) Slow intravenous infusion (d) All of the above routes
Description : Adrenaline raises blood glucose level by the following actions except (a) Inducing hepatic glycogenolysis (b) Inhibiting insulin secretion from pancreatic ß cells (c) Augmenting glucagons secretion from pancreatic a cells (d) Inhibiting peripheral glucose utilization
Description : a2–adrenergic receptors are associated with following except (a) Increase in phospholipase C activity (b) Increase in potassium channel conductance (c) Decrease in calcium channel conductance (d) Increase in adenylyl cyclase activity
Description : Low doses of adrenaline dilate the following vascular bed (a) Cutaneous (b) Mucosal (c) Renal (d) Skeletal muscle
Description : A sympathomimetic amine that acts almost exclusively by releasing noradrenaline from the nerve endings is (a) Ephedrine (b) Dopamine (c) Isoprenaline (d) Tyramine
Description : Choose the correct statement from the following about a1 – adrenergic receptor agonists (a) Norepinephrine > isoproterenol > epinephrine (b) Norepinephrine < epinephrine > isoproterenol (c) Epinephrine = norepinephrine >> isoproterenol (d) Epinephrine > isoproterenol > norepinephrine
Description : Tyramine induces release of noradrenaline from adrenergic nerve endings (a) By depolarizing the axonal membrane (b) By mobilizing Ca2+ (c) By a nonexocytotic process (d) Only in the presence of MAO inhibitors
Description : The most efficacious inhibitor of catecholamine synthesis in the body is (a) a - methyl – p - tyrosine (b) a - methyldopa (c) a - methyl - norepinephrine (d) Pyrogallol
Description : Select the correct statement from the following about a1 – adrenergic receptor agonists (a) Isoproterenol > epinephrine = norepinephrine (b) Epinephrine > isoproterenol > norepinephrine (c) Isoproterenol = epinephrine = norepinephrine (d) Epinephrine = norepinephrine > isoproterenol
Description : Atropine is contraindicated in (a) Cyclic AMP (b) Inositol trisphosphate (c) Diacyl glycerols (d) G protein
Description : The most effective antidote for belladonna poisoning is (a) Neostigmine (b) Physostigmine (c) Pilocarpine (d) Methacholine
Description : The most suitable mydratic for a patient of corneal ulcer is (a) Atropine sulfate (b) Homatropine (c) Cyclopentolate (d) Tropicamide
Description : Which of the following mydriatics has the fastest and briefest action ? (a) Atropine (b) Homatropine (c) Tropicamide (d) Cyclopentolate
Description : Glycopyrrolate is the preferred antimuscannic drug for use before and during surgery because (a) It is potent and fast acting (b) It has no central action (c) It has antisecretory and vagolytic actions (d) All of the above
Description : Which of the following anticholinergic drugs is primarily used in preanaesthetic medication and during surgery (a) Glycopyrrolate (b) Pipenzolate methyl bromide (c) Isopropamide (d) Dicyclomine
Description : Hyoscine differs from atropine in that it (a) Exerts depressant effects on the CNS at relatively low doses (b) Exerts more potent effects on the heart than on the eye (c) Is longer acting (d) Has weaker antimotion sickness activity
Description : a1 – receptors are coupled with _______ G protein. (a) Gs (b) Gi (c) Gq (d) Go
Description : Atropine does not exert relaxant/ antispasmodic effect on the following muscle (a) Intestinal (b) Ureteric (c) Bronchial (d) Layngeal
Description : The cardiac muscarinic receptors (a) Are of the M1 subtype (b) Are of the M2 subtype (c) Are selectively blocked by pirenzepine (d) Function through the PIP2 ? IP3/DAG pathway
Description : Muscarinic cholinergic receptors (a) Are located only on parasympathetically innervated effector cells (b) Mediate responses by opening an instrinsic Na+ ion channel (c) Are present on vascular endothelium which has no cholinergic nerve supply (d) Predominate in the autonomic ganglia
Description : Which of the following organs is innervated only by parasympathetic nerves ? (a) Iris muscles (b) Ciliary muscle (c) Sweat glands (d) Splenic capsule
Description : Yohimbine is an antagonist of ______ receptors. (a) a1 (b) a2 (c) both (a) and (b) (d) None of the above
Description : Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on ... the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels
Description : A patient is admitted to the emergency room with orthostatic hypotension and evidence of marked GI bleeding. Which of the following most accurately describes the probable autonomic response to this ... constricted pupils, increased bowel sounds (e) Rapid heart rate, constricted pupils, warm skin
Description : Typical results of beta-receptor activation include which one of the following? (a) Hypoglycemia (b) Lipolysis (c) Glycogen synthesis (d) Decreased skeletal muscle tremor (e) Decreased rennin secretion
Description : Action of norepinephrine and epinephrine are terminated by (a) Reuptake into nerve terminal (b) Dilution by diffusion and uptake at extraneuronal site (c) Metabolic transformation (d) All of the above
Description : A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in ... prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol