Description : Glycopyrrolate is the preferred antimuscarinic drug for use before and during surgery because: A. It is potent and fast acting B. It has no central action C. It has antisecretory and vagolytic actions D. All of the above
Last Answer : B. It has no central action
Last Answer : D. All of the above
Description : Which of the following anticholinergic drugs is primarily used in preanaesthetic medication and during surgery (a) Glycopyrrolate (b) Pipenzolate methyl bromide (c) Isopropamide (d) Dicyclomine
Last Answer : Ans: A
Description : Hyoscine differs from atropine in that it (a) Exerts depressant effects on the CNS at relatively low doses (b) Exerts more potent effects on the heart than on the eye (c) Is longer acting (d) Has weaker antimotion sickness activity
Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine
Last Answer : C. They are devoid of CNS and ocular effects
Description : Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine
Last Answer : Ans: E
Description : When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential
Last Answer : Ans: D
Description : Adrenaline raises blood glucose level by the following actions except (a) Inducing hepatic glycogenolysis (b) Inhibiting insulin secretion from pancreatic ß cells (c) Augmenting glucagons secretion from pancreatic a cells (d) Inhibiting peripheral glucose utilization
Description : A 7-years-old boy has a significant bedwetting problem. A long-acting indirect sympathomimetic agent sometimes used by the oral route for this and other indications is (a) Dobutamine (b) Ephedrine (c) Epinephrine (d) Isoproterenol (e) Phenylephrine
Last Answer : Ans: B
Description : A direct-acting cholinomimetic that is lipid-soluble and often used in the treatment of glaucoma is (a) Acetylcholine (b) Bethanechol (c) Physostigmine (d) Pilocarpine (e) Neostigmine
Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects
Last Answer : D. It produces prominent extrapyramidal side effect
Description : The drug which produces vasoconstriction despite being an a adrenergic blocker is (a) Phenoxybenzamine (b) Ergotamine (c) Dihydroergotoxine (d) Tolazoline
Description : A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in ... prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Description : Which of the following is the drug of choice in treating suicidal overdose of digitoxin ? (a) Digoxin antibodies (b) Lidocaine (c) Magnesium (d) Potassium (e) Quinidine
Description : In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? (a) Decreased atrioventricular conduction velocity (b) Decreased ejection time (c) Increased ectopic automaticity (d) Increased ectopic automaticity (e) All of the above
Description : Which of the following is a vasodilator drug used for hypertension that lacks a direct effect on autonomic receptors but may provoke anginal attacks? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Last Answer : Ans: C
Description : Which of the following drugs is the drug of choice in anaphylaxis associated with bronchospasm and hypotension ? (a) Cortisone (b) Epinephrine (c) Isoproterenol (d) Norepinephrine (e) Phenylephrine
Description : Your patient is to receive a selective ß2 stimulant drug ß2 selective stimulant are often effective in (a) Angina due to coronary insufficiency (b) Asthma (c) Chronic heart failure (d) Delayed or insufficiently strong labor (e) All of the above
Description : Che following is true of desmopressin except: A. It is nonselective V1 and V2 receptor agonist B. It is more potent and longer acting than arginine vasopressin (AVP) C. It is preferred over AVP for treatment of diabetes insipidus D. It can be administered orally
Last Answer : A. It is nonselective V1 and V2 receptor agonist
Description : Desmopressin is preferred over arginine vasopressin in the treatment of diabetes insipidus for the following reasons except: A. It is a more potent antidiuretic B. It is a selective vasopressin V1 receptor agonist C. It has little vasoconstrictor activity D. It is longer acting
Last Answer : B. It is a selective vasopressin V1 receptor agonist
Description : Propranolol does not block the following action of adrenaline (a) Bronchodilation (b) Lipolysis (c) Muscle tremor (d) Mydriasis
Description : Ephedrine is similar to adrenaline in the following feature (a) Potency (b) Inability to penetrate blood-brain barrier (c) Duration of action (d) Producing both a and ß adrenergic effects
Description : Which of the following mydriatics has the fastest and briefest action ? (a) Atropine (b) Homatropine (c) Tropicamide (d) Cyclopentolate
Description : Action of norepinephrine and epinephrine are terminated by (a) Reuptake into nerve terminal (b) Dilution by diffusion and uptake at extraneuronal site (c) Metabolic transformation (d) All of the above
Description : Cromolyn has as its major action (a) Block of calcium channels in lymphocytes (b) Block of mediator release from mast cells (c) Block of phosphodiesterase in mast cells and basophils (d) Smooth muscle relaxation in the bronchi (e) Stimulation of cortisol release by the adrenals
Description : The biochemical mechanism of action of digitalis is associated with (a) A decrease in calcium uptake by the sarcoplasmic reticulum (b) An increase in ATP synthesis (c) A modification of the actin molecule (d) An increase in systolic intracellular calcium levels (e) A block of sodium/calcium exchange
Description : Which of the following best describes the mechanism of action of scopolamine ? (a) Irreversible antagonist at nicotinic receptors (b) Irreversible antagonist at muscarinic receptors (c) ... receptors (d) Reversible antagonist at muscarinic receptors (e) Reversible antagonist at nicotinic receptors
Description : Children are more susceptible than adults to the following action of atropine: A. Tachycardia producing B. Cycloplegic C. Gastric antisecretory D. Central excitant and hyperthermic
Last Answer : D. Central excitant and hyperthermic
Description : The progestin used in combined oral contraceptive pill is a 19-nortestosterone derivative because: A. They have potent antiovulatory action of their own B. They do not produce any metabolic effects C. They produce fewer side effects D. They are longer acting
Last Answer : A. They have potent antiovulatory action of their own
Description : Use of glycopyrrolate in preanaesthetic medication serves the following purposes except: A. Prevents respiratory secretions during anaesthesia B. Guards against reflex vagal bradycardia during ... Produces amnesia for perioperative events D. Reduces the probability of occurrence of laryngospasm
Last Answer : C. Produces amnesia for perioperative events
Description : Which of the following anticholinergic drugs is primarily used in preanaesthetic medication and during surgery: A. Glycopyrrolate B. Pipenzolate methyl bromide C. Isopropamide D. Dicyclomine
Last Answer : A. Glycopyrrolate
Description : Prazosin is an effective antihypertensive while nonselective a adrenergic blockers are not because (a) It is the only orally active a blocker (b) It improves plasma lipid profile (c) It does not concurrently enhance noradrenaline release (d) It improves urine flow in males with prostatic hypertrophy
Description : If the dose-response curves of a drug for producing different actions are widely separated on the dose axis, the drug is: A. Highly potent B. Highly efficacious C. Highly toxic D. Highly selective
Last Answer : D. Highly selective
Description : Ranitidine differs from cimetidine in the following respect: A. It is less potent B. It is shorter acting C. It does not have antiandrogenic action D. It produces more CNS side effect
Last Answer : C. It does not have antiandrogenic action
Description : Pyridostigmine differs from neostigmine in that: A. It is more potent orally B. It is longer acting C. It produces less muscarinic side effects D. It does not have any direct action on NM receptors
Last Answer : B. It is longer acting
Description : Muscarinic cholinergic receptors (a) Are located only on parasympathetically innervated effector cells (b) Mediate responses by opening an instrinsic Na+ ion channel (c) Are present on vascular endothelium which has no cholinergic nerve supply (d) Predominate in the autonomic ganglia
Description : Reserprine, an alkaloid derived from the root of Rauwolfia serpentina (a) Can be used to control hyperglycemia (b) Can cause severe depression of mood (c) Can decrease gastrointestinal secretion and motility (d) Has no cardiac effects (e) A spare receptor agonist
Description : The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case
Last Answer : D. They are the preferred drugs in advanced cases
Description : Which of the following conditions is an indication for the use of calcitonin? (a) Chronic renal failure (b) Hypoparathyroidism (c) Intestinal osteodystrophy (d) Pager’s disease (e) Rickets
Description : Accepted therapeutic indications for the use of antimuscarinic drugs include all of the following except (a) Hypertension (b) Motion sickness (c) Parkinson’s disease (d) Postoperative bladder spasm (e) Traveler’s diarrhea
Description : Phenylephrine (a) Mimics the transmitter at post-synaptic receptors (b) Displaces transmitter from axonal terminal (c) Inhibits synthesis of transmitter (d) None of the above
Description : Propanolol can be used to allay anxiety associated with (a) Chronic neurotic disorer (b) Schizopherenia (c) Short-term stressful situation (d) Endogenous depression