Description : The conversion of pyruvate to acetyl CoA and CO2 (A) Is reversible (B) Involves the participation of lipoic acid (C) Depends on the coenzyme biotin (D) Occurs in the cytosol
Last Answer : B
Description : De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by ... synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis
Last Answer : Answer : A
Description : Which one of the following statements concerning glucose metabolism is correct? (A) The conversion of Glucose to lactate occurs only in the R.B.C (B) Glucose enters most cells by a mechanism in ... ) An elevated level of insulin leads to a decreased level of fructose 2, 6-bisphosphate in hepatocyte
Last Answer : C
Description : Pyruvate dehydrogenase contains all except (A) Biotin (B) NAD (C) FAD (D) CoA
Description : The coenzyme not involved in the formation of acetyl-CoA from pyruvate is (A) TPP (B) Biotin (C) NAD (D) FAD
Last Answer : Answer : B
Description : The coenzyme required for conversion of pyruvate to oxaloacetate is (A) FAD (B) NAD (C) TPP (D) Biotin
Last Answer : Answer : D
Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP
Description : Which of the following statements regarding T.C.A cycle is true? (A) It is an anaerobic process (B) It occurs in cytosol (C) It contains no intermediates for Gluconeogenesis (D) It is amphibolic in nature
Last Answer : D
Description : The process of breakdown of glycogen to glucose in the liver and pyruvate and lacate in the muscle is known as (A) Glyogenesis (B) Glycogenolysis (C) Gluconeogenesis (D) Cellular degradation
Description : Which of the following reactions is unique to gluconeogenesis? (A) Lactate Pyruvate (B) Phosphoenol pyruvate pyruvate (C) Oxaloacetate phosphoenol pyruvate (D) Glucose-6-phosphate Fructose-6-phosphate
Description : The 4 rate limiting enzymes of gluconeogenesis are (A) Glucokinase, Pyruvate carboxylae phosphoenol pyruvate carboxykinase and glucose-6-phosphatase (B) Pyruvate carboxylase, phosphoenol ... fructokinase, pyruvate carboxylase, phosphoenol pyruvate carboxykinase and fructose 1, 6 diphosphatase
Description : Ethanol decreases gluconeogenesis by (A) Inhibiting glucose-6-phosphatase (B) Inhibiting PEP carboxykinase (C) Converting NAD+ into NADH and decreasing the availability of pyruvate (D) Converting NAD+ into NADH and decreasing the availability of lactate
Description : Hypoglycemia depresses insulin secretion and thus increases the rate of (A) Hydrolysis (B) Reduction (C) Gluconeogenesis (D) Respiratory acidosis
Last Answer : Answer : C
Description : Gluconeogenesis occurs in _______ of cells. a. Mitochondria. b. Cytosol. c. Golgi bodies. d. Nucleus.
Last Answer : b. Cytosol.
Description : Which one of the following statements is incorrect? (A) Insulin increases glucose phosphorylation (B) Insulin increases glycolysis (C) Insulin augments HMP shunt (D) Insulin promotes gluconeogenesis
Description : Insulin increases (A) Glycogenesis (B) Gluconeogenesis (C) Lipolysis (D) Blood glucose
Description : Insulin decreases (A) Glycogenesis (B) Glyolysis (C) Gluconeogenesis (D) Tubular reabsorption of glucose
Description : A pathway that requires NADPH as a cofactor is (A) Extramitochondrial folic acid synthesis (B) Ketone body formation (C) Glycogenesis (D) Gluconeogenesis
Description : The following is true about gluconeogenesis: a. it occurs in liver b. it occurs in kidney c. it occurs in adipose tissue d. it is inhibited by glucagon
Last Answer : it occurs in liver
Description : Action of glycogen synthase is inhibited by (A) Insulin (B) Glucose (C) Mg2+ (D) Cyclic AMP
Description : De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP
Description : For reduction enzyme HMG-CoA reductase requires cofactor: (A) NADPH (B) NADP (C) NAD (D) FAD
Description : Ketosis reflects (A) Increased hepatic glucose liberation (B) Increased fatty acid oxidation (C) Increased carbohydrate utilisation (D) Incresed gluconeogenesis
Description : Synthesis of Glucose from amino acids is termed as (A) Glycolysis (B) Gluconeogenesis (C) Glycogenesis (D) Lipogenesis
Description : β-Oxidation of fatty acids requires all the following coenzymes except (A) CoA (B) FAD (C) NAD (D) NADP
Description : UDP glucose is converted to UDP glucurronate, a reaction catalysed by UDP glucose dehydrogenase requires (A) NAD+ (B) FAD (C) NADP (D) FMN
Description : Oxidation of fatty acids occurs (A) In the cytosol (B) In the matrix of mitochondria (C) On inner mitochondrial membrane (D) On the microsomes
Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes
Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes
Description : During synthesis of porphyrins, synthesis of δ-amino levulinic acid occurs in (A) Mitochondria (B) Cytosol (C) Both in mitochondria and cytosol (D) Ribosomes
Description : De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these
Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these
Description : Sulphur containing coenzyme is (A) NAD (B) FAD (C) Pyridoxal phosphate (D) Biotin
Description : The cofactor or its derivative required for the conversion of acetyl CoA to malonylCoA is (A) FAD (B) ACP (C) NAD+ (D) Biotin
Description : Carboxylation of acetyl—CoA to malonyl — CoA takes place in presence of (A) FAD+ (B) Biotin (C) NAD+ (D) NADP+
Description : Glucocorticoids increase the synthesis of all of the following except (A) Glucokinase (B) Glucose-6-phosphatase (C) Fructose-1, 6-biphosphatase (D) Pyruvate carboxylase
Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones
Description : A 55-year-old male undergoes a total abdominal colectomy. Which of the following statement(s) is/are true concerning the hormonal response to the surgical procedure? a. Adrenocorticotropic ... in serum insulin and a fall in glucagon accelerate hepatic glucose production and maintain gluconeogenesis
Last Answer : Answer: a, c One of the earliest consequence of a surgical procedure is the rise in levels of circulating cortisol that occur in response to a sudden outpouring of ACTH ... hepatic glucose production, and, with other hormones (epinephrine and glucocorticoids), gluconeogenesis is maintained
Description : Glucocorticoids impair carbohydrate tolerance by: A. Promoting gluconeogenesis in liver B. Depressing glucose uptake into skeletal muscles C. Inhibiting insulin secretion D. Both A and B are correct
Last Answer : D. Both A and B are correct
Description : Metformin acts by: A. Releasing insulin from pancreas B. Suppressing gluconeogenesis and glucose output from liver
Last Answer : B. Suppressing gluconeogenesis and glucose output from liver
Description : Pyruvate dehydrogenase complex is located in (A) Cytosol (B) Lysosomes (C) Mitochondria (D) Endoplasmic reticulum
Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase
Description : The enzyme pyruvate carboxylase is present in (A) Cytosol (B) Mitochondria (C) Nucleus (D) Golgi bodies
Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA
Description : An enzyme involved in gluconeogenesis is (A) Pyruvate kinase (B) Pyruvate carboxylase (C) Hexokinase (D) Phosphohexose isomerase
Description : The following metabolic abnormalities occur in Diabetes mellitus except (A) Increased plasma FFA (B) Increased pyruvate carboxylase activate (C) Decreased lipogenesis (D) Decreased gluconeogenesis
Description : Which one of the following is a rate limiting enzyme of gluconeogenesis? (A) Hexokinase (B) Phsophofructokinase (C) Pyruvate carboxylase (D) Pyruvate kinase
Description : Biotin is a coenzyme for (A) Pyruvate dehydrogenase (B) Pyruvate carboxylase (C) PEP carboxykinase (D) Glutamate pyruvate transminase
Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin
Description : Biotin is a coenzyme for (A) Pyruvate carboxylase (B) Acetyl CoA carboxylase (C) Propionyl CoA carboxylase (D) All of these