The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL

The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
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Familial hypertriaacylglycerolemia is associated with (A) Over production of VLDL (B) Increased LDL concentration (C) Increased HDL concentration (D) Slow clearance of chylomicrons

Description : Familial hypertriaacylglycerolemia is associated with (A) Over production of VLDL (B) Increased LDL concentration (C) Increased HDL concentration (D) Slow clearance of chylomicrons

Last Answer : Answer : A

Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Description : Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Last Answer : Answers-1 Familial hypercholesterolaemia is an autosomal dominant condition manifest by increased LDL concentrations (not chylomicrons) due to constitutional abnormalities and reduced numbers of ... are characteristic and the condition is associated with a premature cardiovascular mortality.

Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Description : Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Last Answer : Answers-1 Familial hypercholesterolaemia is an autosomal dominant condition manifest by increased LDL concentrations (not chylomicrons) due to constitutional abnormalities and reduced numbers of ... are characteristic and the condition is associated with a premature cardiovascular mortality.

Apolipoprotein B-100 is present in (A) Chylomicrons (B) VLDL only (C) LDL only (D) VLDL and LDL

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Apolipoprotein B-48 is present in (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Description : Apolipoprotein B-48 is present in (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

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Cholesterol by a feed back mechanism inhibits the activity of (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Thilase (D) Mevalonate kinase

Description : Cholesterol by a feed back mechanism inhibits the activity of (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Thilase (D) Mevalonate kinase

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Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid

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Down regulation is (A) Increased destruction of a hormone (B) Feed back inhibition of hormone secretion (C) Decreased concentration of a hormone in blood (D) Decrease in number of receptors for a hormone

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With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the formation of red blood cell membranes. 3) Chylomicrons are synthesized in the liver. 4) HDL is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

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Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.

With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the formation of red blood cell membranes. 3) Chylomicrons are synthesized in the liver. 4) HDL is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

Description : With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the ... is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.

HMG-CoA reductase activity is increased by administration of the hormone: (A) Insulin (B) Glucagon (C) Epinephrine (D) Glucocorticoids

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Last Answer : Answer : A

Which of the following lipoproteins would contribute to a measurement of plasma cholesterol in a normal individual following a 12 hr fast? (A) Chylomicrons (B) VLDL (C) Both VLDL and LDL (D) LDL

Description : Which of the following lipoproteins would contribute to a measurement of plasma cholesterol in a normal individual following a 12 hr fast? (A) Chylomicrons (B) VLDL (C) Both VLDL and LDL (D) LDL

Last Answer : Answer : D

Elevated plasma level of the following projects against atherosclerosis: (A) Chylomicrons (B) VLDL (C) HDL (D) LDL

Description : Elevated plasma level of the following projects against atherosclerosis: (A) Chylomicrons (B) VLDL (C) HDL (D) LDL

Last Answer : Answer : C

Familial hypercholesterolemia?

Description : Familial hypercholesterolemia?

Last Answer : DefinitionFamilial hypercholesterolemia is a disorder of high LDL ("bad") cholesterol that is passed down through families, which means it is inherited. The condition begins at birth and can cause heart attacks ... LDL in the blood. High levels of LDL cholesterol make you more likely to have narro

The apolipoprotein which from the integral component of VLDL is (A) B-100 (B) B-48 (C) A (D) D

Description : The apolipoprotein which from the integral component of VLDL is (A) B-100 (B) B-48 (C) A (D) D

Last Answer : Answer : A

The apolipoprotein which acts as ligand for LDL receptor is (A) B-48 (B) B-100 (C) A (D) C

Description : The apolipoprotein which acts as ligand for LDL receptor is (A) B-48 (B) B-100 (C) A (D) C

Last Answer : Answer : B

The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate

Description : The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate

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In the biosynthesis of cholesterol, the rate limiting enzyme is (A) Mevalonate kinase (B) HMG-CoA synthetase (C) HMG-CoA reductase (D) Cis-prenyl transferase

Description : In the biosynthesis of cholesterol, the rate limiting enzyme is (A) Mevalonate kinase (B) HMG-CoA synthetase (C) HMG-CoA reductase (D) Cis-prenyl transferase

Last Answer : Answer : C

For reduction enzyme HMG-CoA reductase requires cofactor: (A) NADPH (B) NADP (C) NAD (D) FAD

Description : For reduction enzyme HMG-CoA reductase requires cofactor: (A) NADPH (B) NADP (C) NAD (D) FAD

Last Answer : Answer : A

HMG-CoA is converted to mevalonate by reduction catalysed by (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Mevalonate kinase (D) Thiolase

Description : HMG-CoA is converted to mevalonate by reduction catalysed by (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Mevalonate kinase (D) Thiolase

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The rage limiting step cholesterol biosynthesis is (A) Squalene synthetase (B) Mevalonate kinase (C) HMG CoA synthetase (D) HMG CoA reductase

Description : The rage limiting step cholesterol biosynthesis is (A) Squalene synthetase (B) Mevalonate kinase (C) HMG CoA synthetase (D) HMG CoA reductase

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Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase

Description : Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase

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Increased serum levels of which of the following may be associated with a decreased risk of atherosclerosis? (a) Very low-density lipoproteins (VLDL) (b) Low-density lipoproteins (LDL) (c) Intermediate – density lipoproteins (IDL) (d) High-density lipoproteins (HDL) (e) Cholesterol

Description : Increased serum levels of which of the following may be associated with a decreased risk of atherosclerosis? (a) Very low-density lipoproteins (VLDL) (b) Low-density lipoproteins (LDL) (c) Intermediate – density lipoproteins (IDL) (d) High-density lipoproteins (HDL) (e) Cholesterol

Last Answer : Ans: D

Answer: a, b, c, d Free oxygen radicals are chemical species that are intermediates in the normal process of cellular respiration. Oxidants that are free radicals have been implicated as initiators of reactions which lead to a variety of cellular injuries. Oxidants are derived from several sources, notably phagocytes. Among the effects of oxygen free radicals are membrane lipid peroxidation, DNA strand breaks, cytoskeletal disassembly and inhibition of glucose metabolism leading to decreased cellular ATP concentrations. (Figure 6-16) 187 Which of the following acute-phase protein levels are increased in human plasma following acute inflammation? a. C-reactive protein b. Serum amyloid c. a -Proteinase inhibitor d. Fibrinogen e. Albumin

Description : Answer: a, b, c, d Free oxygen radicals are chemical species that are intermediates in the normal process of cellular respiration. Oxidants that are free radicals have been implicated as initiators of ... a. C-reactive protein b. Serum amyloid c. a -Proteinase inhibitor d. Fibrinogen e. Albumin

Last Answer : Answer: a, b, c, d The acute-phase response is a series of homeostatic responses of the organism to tissue injury in infection and inflammation. After an inflammatory stimulus occurs, a number ... 30% to 50% of the level before injury. The reason for the decrease in production is poorly understood

Genetic deficiency of lipoprotein lipase causes hyperlipoproteinaemia of following type: (A) Type I (B) Type IIa (C) Type IIb (D) Type V

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Correct ordering of lipoprotein molecules from lowest to the greater density is (A) LDL, IDL, VLDL, chylomicron (B) Chylomicron, VLDL, IDL, LDL (C) VLDL, IDL, LDL, chylomicron (D) LDL, VLDL, IDL, chylomicron

Description : Correct ordering of lipoprotein molecules from lowest to the greater density is (A) LDL, IDL, VLDL, chylomicron (B) Chylomicron, VLDL, IDL, LDL (C) VLDL, IDL, LDL, chylomicron (D) LDL, VLDL, IDL, chylomicron

Last Answer : Answer : B

The majority of absorbed fat appears in the forms of (A) HDL (B) Chylomicrone (C) VLDL (D) LDL

Description : The majority of absorbed fat appears in the forms of (A) HDL (B) Chylomicrone (C) VLDL (D) LDL

Last Answer : Answer : B

The lipoprotein with the fastest electrophoretic mobility and lowest TG content are (A) VLDL (B) LDL (C) HDL (D) Chylomicrones

Description : The lipoprotein with the fastest electrophoretic mobility and lowest TG content are (A) VLDL (B) LDL (C) HDL (D) Chylomicrones

Last Answer : Answer : C

Chylomicron, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) all are serum lipoproteins. What is the correct ordering of these particles from the lowest to the greatest density? (A) LDL, IDL, VLDL, Chylomicron (B) Chylomicron, VLDL, IDL, LDL (C) VLDL, IDL, LDL, Chylomicron (D) Chylomicron, IDL, VLDL, LDL

Description : Chylomicron, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) all are serum lipoproteins. What is the correct ordering of these particles from the lowest to ... , IDL, LDL (C) VLDL, IDL, LDL, Chylomicron (D) Chylomicron, IDL, VLDL, LDL

Last Answer : Answer : B

The first lipoprotein to be secreted by the liver is (A) VLDL (B) nascent VLDL (C) LDL (D) IDL

Description : The first lipoprotein to be secreted by the liver is (A) VLDL (B) nascent VLDL (C) LDL (D) IDL

Last Answer : Answer : B

Increase in blood of this class of lipoproteins is beneficial to ward off coronary heart disease: (A) HDL (B) LDL (C) VLDL (D) IDL

Description : Increase in blood of this class of lipoproteins is beneficial to ward off coronary heart disease: (A) HDL (B) LDL (C) VLDL (D) IDL

Last Answer : Answer : A

Free fatty acids released from adipose tissue are transported in blood by (A) Albumin (B) VLDL (C) LDL (D) HDL

Description : Free fatty acids released from adipose tissue are transported in blood by (A) Albumin (B) VLDL (C) LDL (D) HDL

Last Answer : Answer : A

Activated lecithin cholesterol acyl transferase is essential for the conversion of (A) VLDL remnants into LDL (B) Nascent HDL into HDL (C) HDL2 into HDL3 (D) HDL3 into HDL2

Description : Activated lecithin cholesterol acyl transferase is essential for the conversion of (A) VLDL remnants into LDL (B) Nascent HDL into HDL (C) HDL2 into HDL3 (D) HDL3 into HDL2

Last Answer : Answer : B

Heparin releasable hepatic lipase converts (A) VLDL remnants into LDL (B) Nascent HDL into HDL (C) HDL2 into HDL3 (D) HDL3 into HDL2

Description : Heparin releasable hepatic lipase converts (A) VLDL remnants into LDL (B) Nascent HDL into HDL (C) HDL2 into HDL3 (D) HDL3 into HDL2

Last Answer : Answer : C

Nascent HDL of intestinal origin acquires Apo C and Apo E from (A) Chylomicrons (B) VLDL (C) LDL (D) HDL of the hepatic origin

Description : Nascent HDL of intestinal origin acquires Apo C and Apo E from (A) Chylomicrons (B) VLDL (C) LDL (D) HDL of the hepatic origin

Last Answer : Answer : D

VLDL remnant may be converted into (A) VLDL (B) LDL (C) HDL (D) Chylomicrons

Description : VLDL remnant may be converted into (A) VLDL (B) LDL (C) HDL (D) Chylomicrons

Last Answer : Answer : C

Cholesterol is transported from liver to extrahepatic tissues by (A) Chylomicrons (B) VLDL (C) HDL (D) LDL

Description : Cholesterol is transported from liver to extrahepatic tissues by (A) Chylomicrons (B) VLDL (C) HDL (D) LDL

Last Answer : Answer : D

Triglycerides are transported from liver to extrahepatic tissues by (A) Chylomicrons (B) VLDL (C) HDL (D) LDL

Description : Triglycerides are transported from liver to extrahepatic tissues by (A) Chylomicrons (B) VLDL (C) HDL (D) LDL

Last Answer : Answer : B

The lipoprotein richest in cholesterol is (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Description : The lipoprotein richest in cholesterol is (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Last Answer : Answer : C

The highest phospholipids content is found in (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Description : The highest phospholipids content is found in (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Last Answer : Answer : D

Dietary fats after absorption appear in the circulation as (A) HDL (B) VLDL (C) LDL (D) Chylomicron

Description : Dietary fats after absorption appear in the circulation as (A) HDL (B) VLDL (C) LDL (D) Chylomicron

Last Answer : Answer : D

Nascent chylomicron receives apolipoproteins C and E from (A) VLDL remnant (B) VLDL (C) LDL (D) HDL

Description : Nascent chylomicron receives apolipoproteins C and E from (A) VLDL remnant (B) VLDL (C) LDL (D) HDL

Last Answer : Answer : D

Apolipoprotiens C-I, C-II and C-III are present in all of the following except (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Description : Apolipoprotiens C-I, C-II and C-III are present in all of the following except (A) Chylomicrons (B) VLDL (C) LDL (D) HDL

Last Answer : Answer : C

Apolipoproteins A-I and A-II are present in (A) LDL only (B) LDL and VLDL (C) HDL only (D) HDL and chylomicrons

Description : Apolipoproteins A-I and A-II are present in (A) LDL only (B) LDL and VLDL (C) HDL only (D) HDL and chylomicrons

Last Answer : Answer : D

A lipoprotein inversely related to the incidence of coronary artherosclerosis is (A) VLDL (B) IDL (C) LDL (D) HDL

Description : A lipoprotein inversely related to the incidence of coronary artherosclerosis is (A) VLDL (B) IDL (C) LDL (D) HDL

Last Answer : Answer : D

A lipoprotein associated with high incidence of coronary atherosclerosis is (A) LDL (B) VLDL (C) IDL (D) HDL

Description : A lipoprotein associated with high incidence of coronary atherosclerosis is (A) LDL (B) VLDL (C) IDL (D) HDL

Last Answer : Answer : A

The lipoprotein associated with activation of LCAT is (A) HDL (B) LDL (C) VLDL (D) IDL

Description : The lipoprotein associated with activation of LCAT is (A) HDL (B) LDL (C) VLDL (D) IDL

Last Answer : Answer : A

A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Last Answer : (C) Lovastatin