Description : De novo synthesis of fatty acids is catalysed by a multi-enzyme complex which contains (A) One-SH group (B) Two-SH groups (C) Three-SH groups (D) Four-SH groups
Last Answer : Answer : D
Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these
Description : De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP
Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?
Last Answer : ATP citrate lyase.
Description : What is the rate limiting enzyme of de novo synthesis of fatty acid?
Last Answer : Acetyl CoA carboxylase.
Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form
Last Answer : Answer : B
Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate
Description : The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms
Last Answer : Answer : A
Description : De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by ... synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis
Description : C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these
Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex
Description : Propionyl CoA is formed on oxidation of (A) Monounsaturated fatty acids (B) Polyunsaturated fatty acids (C) Fatty acids with odd number of carbon atoms (D) None of these FATS AND FATTY ACID METABOLISM 83
Last Answer : Answer : C
Description : Nucleotides required for the synthesis of nucleic acids can be obtained from (A) Dietary nucleic acids and nucleotides (B) De novo synthesis (C) Salvage of pre-existing bases and nucleosides (D) De novo synthesis and salvage
Description : An enzyme common to de novo synthesis of pyrimidine nucleotides and urea is (A) Urease (B) Carbamoyl phosphate synthetase (C) Aspartate transcarbamoylase (D) Argininosuccinase
Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased
Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate
Description : For de novo synthesis of purine nucleotides, glycine provides (A) One nitrogen atom (B) One nitrogen and one carbon atom (C) Two carbon atoms (D) One nitrogen and two carbon atoms
Description : All of the following substances have been used to estimate GFR except (A) Inulin (B) Creatinine (C) Phenol red (D) Mannitol FATS AND FATTY ACID METABOLISM 105
Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103
Description : The major source of cholesterol in arterial smooth muscle cells is from (A) IDL (B) LDL (C) HDL (D) Chylomicrons FATS AND FATTY ACID METABOLISM 101
Description : Cholesterol is excreted as such into ________. (A) Urine (B) Faeces (C) Bile (D) Tears FATS AND FATTY ACID METABOLISM 99
Description : Rancidity of butter is prevented by the addition of (A) Vitamin D (B) Tocopherols (C) Presence of priotin (D) Presence of ‘Cu’ FATS AND FATTY ACID METABOLISM 97
Description : All active prostaglandins have atleast one double bond between positions: (A) 7 and 8 (B) 9 and 10 (C) 11 and 12 (D) 13 and 14 FATS AND FATTY ACID METABOLISM 95
Description : Instead of ester link plasmalogens possess an other link in position: (A) α (B) β (C) γ (D) None of these FATS AND FATTY ACID METABOLISM 93
Description : In haemolytic jaundice, urine shows (A) Absence of bile pigments and urobilinogen (B) Presence of bile pigments and urobilinogen (C) Absence of bile pigments and presence of urobilinogen (D) Presence of bile pigments and absence of urobilinogen FATS AND FATTY ACID METABOLISM 91
Description : Hypocholesterolaemia can occur in (A) Hyperthyroidism (B) Nephrotic syndrome (C) Obstructive jaundice (D) Diabetes mellitus FATS AND FATTY ACID METABOLISM 89
Description : Glycerol released from adipose tissue by hydrolysis of triglycerides is mainly (A) Taken up by liver (B) Taken up by extrahepatic tissues (C) Reutilised in adipose tissue (D) Excreted from the body FATS AND FATTY ACID METABOLISM 85
Description : The Tm for PAH i.e the maximal secretory capacity of the tubule for PAH can be used to gavge the (A) Extent of tubular damage FATS AND FATTY ACID METABOLISM 81 (B) Impairment of the capacity of the tubule to perform osmotic work (C) Impairment of renal plasma flow (D) Glomerular filtration rate
Description : Normal quantity of urobilinogen excreted in the feces per day is about (A) 10–25 mg (B) 50–250 mg (C) 300–500 mg (D) 700–800 mg FATS AND FATTY ACID METABOLISM 79
Description : Ochronosis is an important finding of (A) Tyrosinemia (B) Tyrosinosis (C) Alkaptonuria (D) Richner Hanhart syndrome FATS AND FATTY ACID METABOLISM 77
Description : Palmitic, oleic or stearic acid ester of cholesterol used in manufacture of cosmetic creams is (A) Elaidic oil (B) Lanoline (C) Spermaceti (D) Chaulmoogric oil FATS AND FATTY ACID METABOLISM 75
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Description : De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these
Description : All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase
Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes
Description : The available PRPP is used preferentially for (A) De novo synthesis of purine nucleotides (B) De novo synthesis of pyrimidine nucleotides (C) Salvage of purine bases (D) Salvage of pyrimidine bases
Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase
Description : Xanthosine monophosphate is an intermediate during de novo synthesis of (A) TMP (B) CMP (C) AMP (D) GMP
Description : Inosine monophophate is an intermediate during the de novo synthesis of (A) AMP and GMP (B) CMP and UMP (C) CMP and TMP (D) All of these
Description : For de novo synthesis of purine nucleotides, aspartate provides (A) Nitrogen 1 (B) Nitrogen 3 (C) Nitrogen 7 (D) Nitrogen 9
Description : The nitrogen atoms for de novo synthesis of purine nucleotides are provided by (A) Aspartate and glutamate (B) Aspartate and glycine (C) Aspartate, glutamine and glycine (D) Aspartate, glutamate and glycine
Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes
Description : De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these
Description : Synthesis of polyunsaturated fatty acids involves the enzyme systems: (A) Acyl transferase and hydratase (B) Desaturase and elongase (C) Ketoacyl-CoA reductase and hydratase (D) Dihydroxyacetone phosphate
Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase
Description : Esters of fatty acids with higher alcohols other than glycerol are said to be (A) Waxes (B) Fats (C) Both (A) and (B) (D) None of these
Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue
Description : Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) ... result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin
Description : For synthesis of prostaglandins, the essential fatty acids give rise to a fatty acid containing (A) 12 carbon atoms (B) 16 carbon atoms (C) 20 carbon atoms (D) 24 carbon atoms