Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase
Last Answer : Answer : B
Description : Choose the most potent and most efficacious LDLcholesterol lowering HMG-CoA reductase inhibitor: A. Lovastatin B. Simvastatin C. Pravastatin D. Atorvastatin
Last Answer : D. Atorvastatin
Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin
Last Answer : (C) Lovastatin
Description : Cholesterol by a feed back mechanism inhibits the activity of (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Thilase (D) Mevalonate kinase
Description : In the biosynthesis of cholesterol, the rate limiting enzyme is (A) Mevalonate kinase (B) HMG-CoA synthetase (C) HMG-CoA reductase (D) Cis-prenyl transferase
Last Answer : Answer : C
Description : HMG-CoA is converted to mevalonate by reduction catalysed by (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Mevalonate kinase (D) Thiolase
Description : The rage limiting step cholesterol biosynthesis is (A) Squalene synthetase (B) Mevalonate kinase (C) HMG CoA synthetase (D) HMG CoA reductase
Last Answer : Answer : D
Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above
Last Answer : D. All of the above
Description : The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate
Last Answer : Answer : A
Description : Insulin decreases the activity of (A) cAMP dependent protein kinase (B) HMG CoA-reductas (C) Phosphodiesterase (D) Acetyl CoA-carboxylase
Description : The ‘Committed step’ in the biosynthesis of cholesterol from acetyl CoA is (A) Formation of acetoacetyl CoA from acetyl CoA (B) Formation of mevalonate from HMG CoA (C) Formation of HMG CoA from acetyl CoA and acetoacetyl CoA (D) Formation of squalene by squalene synthetase
Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step
Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid
Last Answer : A. A HMG-CoA reductase inhibitor
Description : Carboxylation of acetyl-CoA to malonylCoA requires the enzyme: (A) Acetyl-CoA carboxylase (B) Pyruvate carboxylase (C) Acetyl transacylase (D) Acyl CoA-synthetase
Description : HMG-CoA reductase activity is increased by administration of the hormone: (A) Insulin (B) Glucagon (C) Epinephrine (D) Glucocorticoids
Description : For reduction enzyme HMG-CoA reductase requires cofactor: (A) NADPH (B) NADP (C) NAD (D) FAD
Description : Select the first line hypolipidemic drug/drugs for treating hypertriglyceridemia in a subject with normal cholesterol level: A. Fibrates B. HMG-CoA reductase inhibitors C. Nicotinic acid D. Both 'A' and 'C' are correc
Last Answer : D. Both 'A' and 'C' are correct
Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity
Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form
Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive
Description : Acetyl CoA carboxylase is activated by (A) Citrate (B) Insulin (C) Both (A) and (B) (D) None of these
Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex
Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase
Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate
Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin
Description : Biotin is a coenzyme for (A) Pyruvate carboxylase (B) Acetyl CoA carboxylase (C) Propionyl CoA carboxylase (D) All of these
Description : Mitochondrial lipogenesis requires (A) bicarbonate (B) biotin (C) acetyl CoA carboxylase (D) NADPH
Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these
Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP
Last Answer : A
Description : Two molecules of acetyl-CoA condense to form acetoacetyl-CoA catalysed by (A) Thiolase (B) Kinase (C) Reductase (D) Isomerase
Description : Thiamine is essential for (A) Pyruvate dehydrogenase (B) Isocitrate dehydrogenase (C) Succinate dehydrogenase (D) Acetyl CoA synthetase ENZYMES 165
Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these
Description : Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III ... hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis
Last Answer : D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis
Description : An allosteric inhibitor of pyruvate dehydrogenase is (A) Acetyl CoA (B) ATP (C) NADH (D) Pyruvate
Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
Description : Retinal is converted into retinoic acid in the presence of (A) Retinal oxidase (B) Retinal carboxylase (C) Retinene reductase(D) Spontaneously
Description : Jamaican vomiting sickness is due to inactivation of the enzyme (A) Pyruvate carboxylase (B) Acyl-Co-A synthetase (C) Acyl-Co-A dehydrogense (D) Thiolase
Description : Conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by the enzyme: (A) Ribonucleotide reductase (B) Thymidylate synthetase (C) CTP synthetase (D) Orotidylic acid decarboxylase
Description : In the biosynthesis of cholesterol, the step which controls the rate and locus of metabolic regulation is (A) Geranyl pyrophosphate farnesyl pyrophosphate (B) Squalene → lanosterol (C) HMG CoA → mevalonate (D) Lanosterol → 1, 4-desmethyl lanosterol
Description : NAD is required as a coenzyme for (A) Malate dehydrogenase (B) Succinate dehydrogenase (C) Glucose-6-phosphate dehydrogenase (D) HMG CoA reductae
Description : HMG CoA is formed in the metabolism of (A) Cholesterol, ketones and leucine (B) Cholesterol, fatty acid and Leucine (C) Lysine, Lecuine and Isoleucine (D) Ketones, Leucine and Lysine
Description : A hydrocarbon formed in cholesterol synthesis is (A) Mevalonate (B) HMG CoA (C) Squalene (D) Zymosterol
Description : What is HMG CoA synthase?
Last Answer : It is the rate-limiting-enzyme in ketogenesis pathway.
Description : Synthesis of polyunsaturated fatty acids involves the enzyme systems: (A) Acyl transferase and hydratase (B) Desaturase and elongase (C) Ketoacyl-CoA reductase and hydratase (D) Dihydroxyacetone phosphate
Description : AMP is an allosteric inhibitor of (A) PRPP synthetase (B) Adenylosucciante synthetase (C) Both (A) and (B) (D) None of these
Description : GMP is an allosteric inhibitor of all the following except (A) PRPP synthetase (B) PRPP glutamyl amido synthetase (C) IMP dehydrogenase (D) Adenylosuccinate synthetase
Description : An allosteric inhibitor of adenylosuccinate synthetase is (A) AMP (B) ADP (C) GMP (D) GDP
Description : Carbamoyl phosphate synthetase structure is marked by change in the presence of (A) N-Acetyl glutamate (B) N-Acetyl Aspartate (C) Neuraminic acid (D) Oxalate
Description : Transfer of the carbamoyl moiety of carbamoyl phosphate to ornithine is catalysed by a liver mitochondrial enzyme: (A) Carbamoyl phosphate synthetase (B) Ornithine transcarbamoylase (C) N-acetyl glutamate synthetase (D) N-acetyl glutamate hydrolase
Description : Both Acyl carrier protein (ACP) of fatty acid synthetase and coenzyme (CoA) are (A) Contain reactive phosphorylated (B) Contain thymidine (C) Contain phosphopantetheine reactive groups (D) Contain cystine reactive groups