Description : Which of the following is a recognised feature of abetalipoproteinaemia? 1) a high serum cholesterol 2) palmar xanthomas 3) advanced atherosclerotic vascular disease 4) abnormal red blood cell morphology 5) severe mental retardation
Last Answer : Answers-4 Acanthocytes are seen in abetalipoproteinaemia. Retinitis pigmentosa is seen in abetalipoproteinaemia. Mental retardation is not present but motor abnormalities and neurodegenerative are seen.
Description : Lipoprotein lipase deficiency is associated with: 1) Abetalipoproteinaemia 2) Combined hyperlipidaemia 3) Familial combined hyperlipidaemia 4) Familial Hypercholesterolaemia 5) Marked Hypertriglyceridaemia
Last Answer : Answers-5 Lipoprotein lipase deficiency is autosomal recessive and associated with increased chylomicrons and marked hypertriglyceridaemia.
Description : Hypolipidemic drugs reduce serum cholesterol and triacylglycerol. The effect of clofibrate is attributed to (A) Block in absorption from G.I.T. (B) Decrease in secretion of triacylglycerol and cholesterol ... by liver (C) Block in the reabsorption of bile acids (D) Decreased synthesis of cholesterol
Last Answer : Answer : B
Description : The protein moiety of lipoprotein is known as (A) Apoprotein (B) Pre-protein (C) Post-protein (D) Pseudoprotein
Last Answer : Answer : A
Description : What is the main apoprotein present in HDL?
Last Answer : Apo A-1, it is the ligand for HDL receptor.
Description : What is the main apoprotein present in LDL?
Last Answer : B100, it is the ligand for LDL receptor.
Description : What is the main apoprotein present in chylomicron.
Last Answer : B48.
Description : All the enzymes involved in the synthesis of cholesterol are found in (A) Mitochondria (B) Golgi apparatus (C) Nucleus (D) Endoplasmic reticulum and cytosol
Last Answer : Answer : D
Description : Vitamin C is required for the synthesis of (A) Bile acids from cholesterol (B) Bile salts from bile acids (C) Vitamin D from cholesterol (D) All of these
Description : All the following correctly describe the intermediate 3-OH-3-methyl glutaryl CoA except (A) It is generated enzymatically in the mitochondrial matrix (B) It is formed in the cytoplasm (C) It inhibits the first step in cholesterol synthesis (D) It is involved in the synthesis of ketone bodies
Last Answer : Answer : C
Description : All statements regarding 3-OH-3 methyl glutaryl CoA are true except (A) It is formed in the cytoplasm (B) Required in ketogenesis (C) Involved in synthesis of Fatty acid (D) An intermediate in cholesterol biosynthesis
Description : CTP is required for the synthesis of (A) Fatty acids (B) Proteins (C) Phospholipids (D) Cholesterol
Description : A hydrocarbon formed in cholesterol synthesis is (A) Mevalonate (B) HMG CoA (C) Squalene (D) Zymosterol
Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones
Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase
Description : In abetalipoproteinemia, the biochemical defect is in (A) Apo-B synthesis (B) Lipprotein lipase activity (C) Cholesterol ester hydrolase (D) LCAT activity
Description : Acetyl CoA is not used for the synthesis of (A) Fatty acid (B) Cholesterol (C) Pyruvic acid (D) Citric acid
Last Answer : C
Description : Select the drug which reduces cholesterol synthesis in liver, increases expression of LDL receptors on hepatocytes and has been found to reduce mortality due to coronary artery disease: A. Simvastatin B. Nicotinic acid C. Gemfibrozil D. Colestipol (
Last Answer : A. Simvastatin
Description : Esterification of cholesterol occurs mainly in (A) Adipose tissue (B) Liver (C) Muscles (D) Kidneys
Description : With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the ... is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.
Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.
Description : Template-directed DNA synthesis occurs in all the following except (A) The replication fork (B) Polymerase chain reaction (C) Growth of RNA tumor viruses (D) Expression of oncogenes
Description : Template-directed DNA synthesis occurs in all the following except (A) The replication fork (B) Polymerase chain reaction (C) Growth of RNA tumor viruses (D) Expression of oneogenes
Description : In mammalian cell cycle, synthesis of DNA occurs during (A) S phase (B) G1 phase (C) Mitotic Phase (D) G2 phase
Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes
Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes
Description : Aldosterone synthesis occurs in (A) Zona reticularis (B) Zona fasciculata (C) Zona glomerulosa (D) Chromaffian cells
Description : Regulation of haem synthesis occurs by (A) Covalent modification (B) Repression - derepression (C) Induction (D) Allosteric regulation
Description : During synthesis of porphyrins, synthesis of δ-amino levulinic acid occurs in (A) Mitochondria (B) Cytosol (C) Both in mitochondria and cytosol (D) Ribosomes
Description : De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by ... synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis
Description : Extramitochondrial synthesis of fatty acids occurs in (A) Mammary glands (B) Lungs (C) Brain (D) All of these
Description : De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these
Description : The synthesis of glucose from pyruvate by gluconeogenesis (A) Requires the participation of biotin (B) Occurs exclusively in the cytosol (C) Is inhibited by elevated level of insulin (D) Requires oxidation/reduction of FAD
Last Answer : A
Description : Six months after beginning atorvastatin, the patient's total and LDL cholesterol concentrations remained above normal and he continued to have anginal attacks despite good adherence to his antianginal ... Increased endocytosis of HDL by the liver (e) Increased lipid hydrolysis by lipoprotein lipase
Last Answer : Ans: C
Description : Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III ... hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis
Last Answer : D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis
Description : Fatty liver is caused due to accumulation of (A) Fatty acids (B) Cholesterol (C) Phospholipids (D) Triacylglycerol
Description : Deterioration of food (rancidity) is due to presence of (A) Cholesterol (B) Vitamin E (C) Peroxidation of lipids (D) Phenolic compounds
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Description : Hyperglycemic effect of glucocorticoids is due to (A) Inactivation of protein phosphatase (B) Inactivation of fructose 1,6-biphosphatase (C) Stimulation of synthesis of pyruvate carboxylase (D) Stimulation of synthesis of eltroxykinase
Description : Hyperargininemia, a defect in urea synthesis develops due to deficiency of the enzyme: (A) Ornithine transcarbamoylase (B) Argininosuccinase (C) Arginase (D) Argininosuccinate synthetase ENZYMES 157
Description : Bassen-Kornzweig syndrome is due to (A) Absence of Apo-C-II (B) Defect in Apo-B synthesis (C) Absence of Apo-E (D) Absence of Apo-D
Description : The biochemical mechanism of action of digitalis is associated with (a) A decrease in calcium uptake by the sarcoplasmic reticulum (b) An increase in ATP synthesis (c) A modification of the actin molecule (d) An increase in systolic intracellular calcium levels (e) A block of sodium/calcium exchange
Last Answer : Ans: D
Description : The most probable mechanism of action of imidazole antifungal drugs is: A. They bind to ergosterol in fungal cell membrane and make it leaky B. They interfere with ergosterol synthesis by fungi C. They interfere with fungal mitosis D. They block oxidative phosphorylation in fungi
Last Answer : B. They interfere with ergosterol synthesis by fungi
Description : ntithyroid drugs exert the following action: A. Inhibit thyroxine synthesis B. Block the action of thyroxine on pituitary C. Block the action of TSH on thyroid D. Block the action of thyroxine on peripheral tissues
Last Answer : A. Inhibit thyroxine synthesis
Description : Antithyroid drugs exert the following action: A. Inhibit thyroxine synthesis B. Block the action of thyroxine on pituitary C. Block the action of TSH on thyroid D. Block the action of thyroxine on peripheral tissues
Last Answer : . Inhibit thyroxine synthesis
Description : Ws of 1991, the most recent award of a Nobel Prize in medicine to a woman scientist went to this esteemed pharmacologist and biochemist. She shared her prize with George Hitchings for ... drugs that selectively block nucleic acid synthesis without damaging normal cells. Name this woman scientist.
Last Answer : ANSWER: (GERTRUDE) ELION
Description : Protein synthesis in an animal cell occurs
Last Answer : Protein synthesis in an animal cell occurs A. On ribosomes present in cytoplasm as well as in ... D. Only on the ribosomes present in cytosol
Description : Which of the following statement(s) is/are true concerning translation of the mRNA message to protein synthesis? a. An adaptor molecule, tRNA, recognizes specific nucleic acid bases and unites them ... and the free amino acid occurs in the free cytoplasm d. Complete protein synthesis takes hours
Last Answer : Answer: a, b The synthesis of protein involves conversion from a four-letter nucleotide language to one of 20 chemically distinct amino acids. This process is referred to as ... translation and be moving down the mRNA molecules simultaneously, thus increasing the rate of protein synthesis
Description : Protein synthesis in an animal cell occurs (a) only on the ribosomes present in cytosol (b) only on ribosome attached to the nuclear envelope and endoplasmic reticulum (c) on ribosome present in the ... as well as in cytoplasm (d) on ribosomes present in cytoplasm as well as in mitochondria.
Last Answer : (d) on ribosomes present in cytoplasm as well as in mitochondria.
Description : .Protein synthesis in an animal cell occurs (a) only on the ribosomes present in cytosol (b) only on ribosome attached to the nuclear envelope and endoplasmic reticulum (c) on ribosome present in the ... as well as in cytoplasm (d) on ribosomes present in cytoplasm as well as in mitochondria.