Prostaglandins are inactivated by (A) 15-Hydroxyprostaglandin dehydrogenase (B) Cyclo-oxygenase (C) Lipo-oxygenase (D) None of these

1 Answer

Answer :

Answer : A

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Description : Anti-inflammatory corticosteroids inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

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Description : Phenylbutazone and indomethacin inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

Last Answer : Answer : C

Description : Cyclo-oxygenase is involved in the synthesis of (A) Prostaglandins (B) Thromboxanes (C) Both (A) and (B) (D) None of these

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Description : Lipo-oxygenase is required for the synthesis of (A) Prostaglandins (B) Leukotrienes (C) Thromboxanes (D) All of these

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Description : True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, ... prostaglandins have a short circulation half-life and exert most of their effects locally.

Last Answer : Answer: ABD DISCUSSION: The eicosanoids are a group of compounds arising from the metabolism of arachidonic acid. The prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase ... effects and may be involved in the physiologic responses associated with anaphylactic and septic shock

Description : By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway.

Last Answer : B. It blocks the cyclo-oxygenase pathway.

Description : How is prostaglandins inactivated? 

Last Answer : Prostaglandins have only very short half life, of about 30 seconds. They are inactivated by the 15- hydroxy-prostaglandin-dehydrogenase which converts 15-OH group to keto group.

Description : The enzyme catalyzing conversion of androstenedione to testosterone is a (A) Oxygenase (B) Dehydrogenase (C) Isomerase (D) Decarboxylase

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Description : Microsomal hydroxylase system contains a (A) Di-oxygenase (B) Mono-oxygenase (C) Both (A) and (B) (D) None of thse

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Description : Name the enzyme that acts both as carboxylase at one time and oxygenase at another time. (A) PEP carboxylase (B) RuBP carboxylase (C) Carbonic anyhdrase (D) None of these

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Description : An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase

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Description : β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase (C) Hydroxylase (D) Transferase

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Description : LCAT activity is associated with which of the lipo-protein complex? (A) VLDL (B) Chylomicrones (C) IDL (D) HDL

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Description : Positive control of induction is best described as a control system in which an operon functions (A) Unless it is switched off by a derepressed repressor protein (B) Only after a repressor protein is ... on (D) Only after an inducer protein, which is activated by an inducer, switch it on

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Description : Zymogen is (A) An intracellular enzyme (B) Serum enzyme (C) A complete extracellular enzyme (D) An inactivated enzyme

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Description : How are the neurotransmitter molecules inactivated after they are released at a synapse?

Last Answer : After a chemical neurotransmitter has been released from the synaptic terminal, its action must be terminated in some way. Otherwise, the continued presence of the transmitter in the ... mechanism is used to inactivate Acetylcholine released from the synaptic terminals of the motor neurons.

Description : The activity of kinins is modulated by (A) Prostaglandins (B) Ca++ (C) Increased cAMP level (D) Increased cGMP level

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Description : Which one of the following hormones is derived most completely from tyrosine? (A) Glucagon (B) Thyroxine (C) Insulin (D) Prostaglandins

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Description : A cup of strong coffee would be expected to (A) Interfere with synthesis of prostaglandins (B) Decrease the effects of Glucagon (C) Enhance the effects of epinephrine (D) Provide the vitamin nicotinic acid

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Description : Which of the following is used for inducing labour? (A) Prostaglandins (B) Prostacyclins (C) Vasopressin (D) Thromboxanes

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Description : The suffix number in the names of prostaglandins gives the number of (A) OH groups (B) Double bonds (C) Acid groups (D) Ketoacids

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Description : Which of tne of the following scientists has not worked in the field of prostaglandins? (A) Voneuler (B) Sultan Karim (C) Andre robet (D) Kendal

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Description : Prostaglandins are (A) C2 unsaturated acids (B) C27 saturated alcohols (C) C20 saturated acids (D) C27 saturated alcohols

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Description : Which of the following property of prostaglandins has been utilized by chinicians in hospital for (A) Inducing fever (B) Causing inflammation (C) Effecting smooth muscle contraction (D) Disaggregation of spermatozoa

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Description : Richest source of prostaglandins in a human male is (A) Blood (B) Urine (C) Semen (D) C.S.F.

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Description : Aspirin blocks the synthesis of (A) Prostaglandins only (B) Prostacyclins only (C) Thromboxanes only (D) All of these

Last Answer : Answer : D

Description : A cup of strong coffee would be expected to (A) Interfere with the synthesis of prostaglandins (B) Decrease the effect of glucagon (C) Enhance the effect of epinephrine (D) Provide the vitamin nicotinic acid

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Description : From arachidonate, synthesis of prostaglandins is catalysed by (A) Cyclooxygenase (B) Lipoxygenase (C) Thromboxane synthase (D) Isomerase

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Description : Cholesterol is the precursor for the biosynthesis of (A) fatty acid (B) prostaglandins (C) bile acids (D) sphingmyelin

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Description : Acrolein Test is positive for (A) Glycerol (B) Prostaglandins (C) Carbohydrates (D) Proteins

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Description : All the following are functions of prostaglandins except (A) Lowering of B.P (B) Introduction of labour (C) Anti inflammatory (D) Prevention of myocardial infraction

Last Answer : Answer : D

Description : Prostaglandins are synthesized in the body from (A) Myristic acid (B) Arachidonic acid (C) Stearic acid (D) Lignoceric acid

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Description : All active prostaglandins have atleast one double bond between positions: (A) 7 and 8 (B) 9 and 10 (C) 11 and 12 (D) 13 and 14 FATS AND FATTY ACID METABOLISM 95

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Description : Prostaglandins have a common structure based on prostanoic acid which contains carbon atoms: (A) 12 (B) 16 (C) 18 (D) 20

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Description : Prostaglandins are liberated in the circulation by the stimulation of (A) Anterior pituitary glands (B) Posterior pituitary glands (C) Adrenal gland (D) Thyroid gland

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Description : The prostaglandins are synthesized from (A) Arachidonic acid (B) Oleic acid (C) Linoleic acid (D) Linolenic acid

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Description : Prostaglandins decrease all of the following except (A) Gastric acid secretion (B) Blood pressure (C) Uterine contraction (D) Platelet aggregation

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Description : Prostaglandins stimulate (A) Aggregation of platelets (B) Lipolysis in adipose tissue (C) Bronchodilatation (D) Gastric acid secretion

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Description : Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

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Description : Slow reacting Substance of Anaphylaxis is a mixture of (A) Prostaglandins (B) Prostacyclins (C) Thromboxanes (D) Leukotrienes

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Description : Prostaglandins lower camp in (A) Adipose tissue (B) Lungs (C) Platelets (D) Adenohypophysis

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Description : Anti-inflammatory corticosteroids inhibit the synthesis of (A) Leukotrienes (B) Prostaglandins (C) Thromboxanes (D) All of these

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Description : All active prostaglandins have at least one double bond between positions (A) 7 and 8 (B) 10 and 11 (C) 13 and 14 (D) 16 and 17

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Description : For synthesis of prostaglandins, the essential fatty acids give rise to a fatty acid containing (A) 12 carbon atoms (B) 16 carbon atoms (C) 20 carbon atoms (D) 24 carbon atoms

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Description : What is the mechanism of action of prostaglandins?

Last Answer : Prostaglandins are local hormones, and function through G-protein coupled receptors In most tissues, PGE increases cAMP level. But in adipose tissue and in renal tubular cells, PGE lowers cAMP level.

Description : How prostaglandins are synthesised?

Last Answer : The arachidonic acid is released by the action of phospholipase A2 on phospholipids prostaglandin synthesis is catalysed by prostaglandin H synthase (PGHS). It contains two separate enzyme activities, cyclo-oxygenase and peroxidase.