Phenylbutazone and indomethacin inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

Phenylbutazone and indomethacin inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase
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Anti-inflammatory corticosteroids inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

Description : Anti-inflammatory corticosteroids inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

Last Answer : Answer : B

Prostaglandins are inactivated by (A) 15-Hydroxyprostaglandin dehydrogenase (B) Cyclo-oxygenase (C) Lipo-oxygenase (D) None of these

Description : Prostaglandins are inactivated by (A) 15-Hydroxyprostaglandin dehydrogenase (B) Cyclo-oxygenase (C) Lipo-oxygenase (D) None of these

Last Answer : Answer : A

Lysolecithin is formed from lecithin by the action of (A) Phospholipase A1 (B) Phospholipase A2 (C) Phospholipase C (D) Phospholipase D

Description : Lysolecithin is formed from lecithin by the action of (A) Phospholipase A1 (B) Phospholipase A2 (C) Phospholipase C (D) Phospholipase D

Last Answer : Answer : B

A ’suicide enzyme’ is (A) Cycloxygenase (B) Lipooxygenase (C) Phospholipase A1 (D) Phospholipase A2

Description : A ’suicide enzyme’ is (A) Cycloxygenase (B) Lipooxygenase (C) Phospholipase A1 (D) Phospholipase A2

Last Answer : Answer : A

Aspirin inhibits the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipae A1 (D) Phospholipase A2

Description : Aspirin inhibits the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipae A1 (D) Phospholipase A2

Last Answer : Answer : B

Cyclo-oxygenase is involved in the synthesis of (A) Prostaglandins (B) Thromboxanes (C) Both (A) and (B) (D) None of these

Description : Cyclo-oxygenase is involved in the synthesis of (A) Prostaglandins (B) Thromboxanes (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Lipo-oxygenase is required for the synthesis of (A) Prostaglandins (B) Leukotrienes (C) Thromboxanes (D) All of these

Description : Lipo-oxygenase is required for the synthesis of (A) Prostaglandins (B) Leukotrienes (C) Thromboxanes (D) All of these

Last Answer : Answer : B

Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Last Answer : Ans: A

Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam

Description : Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam

Last Answer : A. Aspirin

Some hormones produce their intracellular effects by activating (A) Phospholipae A1 (B) Phospholipase B (C) Phospholipase C (D) All of these

Description : Some hormones produce their intracellular effects by activating (A) Phospholipae A1 (B) Phospholipase B (C) Phospholipase C (D) All of these

Last Answer : Answer : C

Zellweger’s syndrome is due to inherited absence of (A) Peroxisomes (B) Phospholipase A1 (C) Acyl-Co-A dehydrogenase (D) Thiolase

Description : Zellweger’s syndrome is due to inherited absence of (A) Peroxisomes (B) Phospholipase A1 (C) Acyl-Co-A dehydrogenase (D) Thiolase

Last Answer : Answer : A

True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, and bronchoconstricting effects of thromboxane A 2 are balanced by the actions of prostacyclin, which produces the opposite effects. C. Leukotriene synthesis is inhibited by the action of nonsteroidal anti-inflammatory drugs (NSAIDs). D. The principal prostaglandins have a short circulation half-life and exert most of their effects locally.

Description : True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, ... prostaglandins have a short circulation half-life and exert most of their effects locally.

Last Answer : Answer: ABD DISCUSSION: The eicosanoids are a group of compounds arising from the metabolism of arachidonic acid. The prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase ... effects and may be involved in the physiologic responses associated with anaphylactic and septic shock

By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway. By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway.

Description : By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway.

Last Answer : B. It blocks the cyclo-oxygenase pathway.

Non steroidal anti inflammatory drugs, such as aspirin act by inhibiting the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipase A2 (D) Lipoprotein lipase

Description : Non steroidal anti inflammatory drugs, such as aspirin act by inhibiting the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipase A2 (D) Lipoprotein lipase

Last Answer : Answer : B

Phospholipase A2 is an enzyme which removes a fatty acid residue from lecithin to form (A) Lecithin fragments (B) Phosphotidic acid (C) Glyceryl phosphate (D) Lysolecithin

Description : Phospholipase A2 is an enzyme which removes a fatty acid residue from lecithin to form (A) Lecithin fragments (B) Phosphotidic acid (C) Glyceryl phosphate (D) Lysolecithin

Last Answer : Answer : D

Platelet activating factor is: a. Generated by the action of phospholipase A2 on membrane phospholipids b. Antiinflammatory in most of its actions c. Synthesized by endothelial and other cells d. Exerts a variety of biologic effects which are platelet-independent

Description : Platelet activating factor is: a. Generated by the action of phospholipase A2 on membrane phospholipids b. Antiinflammatory in most of its actions c. Synthesized by endothelial and other cells d. Exerts a variety of biologic effects which are platelet-independent

Last Answer : Answer: a, c, d Like the eicosanoids, platelet-activating factor (PAF) is not stored in cells but is rapidly produced during inflammation. PAF exerts a variety of biologic effects ... and LTB4. There is considerable overlap and redundancy in the effects produced by PAF and eicosanoids

a2–adrenergic receptors are associated with following except (a) Increase in phospholipase C activity (b) Increase in potassium channel conductance (c) Decrease in calcium channel conductance (d) Increase in adenylyl cyclase activity

Description : a2–adrenergic receptors are associated with following except (a) Increase in phospholipase C activity (b) Increase in potassium channel conductance (c) Decrease in calcium channel conductance (d) Increase in adenylyl cyclase activity

Last Answer : Ans: D

The mechanism of action of cyclosporine involves (a) Activation of calcineurin (b) Binding to cyclophilin to cause inhibition of a cytoplasmic phosphatase (c) Blockade of interleukin – 2- receptors (d) Inhibition of phospholipase A2 (e) Suppression of bone marrow progenitors

Description : The mechanism of action of cyclosporine involves (a) Activation of calcineurin (b) Binding to cyclophilin to cause inhibition of a cytoplasmic phosphatase (c) Blockade of interleukin – 2- receptors (d) Inhibition of phospholipase A2 (e) Suppression of bone marrow progenitors

Last Answer : Ans: B

Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) Cyclooxygenase 1 (b) Cyclooxygenase 2 (c) Glutathione – S – transferase (d) Lipoxygenase (e) Phospholipase A2

Description : Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) ... 2 (c) Glutathione - S - transferase (d) Lipoxygenase (e) Phospholipase A2

Last Answer : Ans: B

Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 blockers inhibit the proton pump in gastric mucosa C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa D. Histamine, acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa

Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa

Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa

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From the following figure, determine the resultant of four forces A1, A2, A3, A4.

Description : From the following figure, determine the resultant of four forces A1, A2, A3, A4.

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Two ores A1 and A2 of a metal M show the following reactivity: `A_(1)=CuCo_(3).Cu(OH)_(3),S=Cu` `P=Cu_(2)I_(2): G=SO_(2)` . Then `A_(2)` is

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Last Answer : Two ores A1 and A2 of a metal M show the following reactivity: `A_(1)=CuCo_(3).Cu(OH)_(3),S=Cu` `P=Cu_(2) ... )` B. `CuO` C. `CuCO_(3)` D. `Cu_(2)S`

Yohimbine is an antagonist of ______ receptors. (a) a1 (b) a2 (c) both (a) and (b) (d) None of the above

Description : Yohimbine is an antagonist of ______ receptors. (a) a1 (b) a2 (c) both (a) and (b) (d) None of the above

Last Answer : Ans: B

If a1 and a2 are the relative volatilities when the pressure in the distillation column is 1 and 2 atm respectively. Pick out the correct statement. (A) a1 = a2 (B) a1 = 2a2 (C) a1 = 0.5 a2 (D) None of these

Description : If a1 and a2 are the relative volatilities when the pressure in the distillation column is 1 and 2 atm respectively. Pick out the correct statement. (A) a1 = a2 (B) a1 = 2a2 (C) a1 = 0.5 a2 (D) None of these

Last Answer : (D) None of these

Two solutions A1 & A2 have pH value of 2 & 6 respectively. It implies that the solution (A) A1is more alkaline than solution A2 (B) A1is highly acidic (C) A2is very slightly acidic (D) Both (B) & (C)

Description : Two solutions A1 & A2 have pH value of 2 & 6 respectively. It implies that the solution (A) A1is more alkaline than solution A2 (B) A1is highly acidic (C) A2is very slightly acidic (D) Both (B) & (C)

Last Answer : (D) Both (B) & (C)

According to equation of continuity, (A) w1a1 = w2a2 (B) w1v1 = w2v2 (C) a1v1 = a2v2 (D) a1/v1 = a2/v2

Description : According to equation of continuity, (A) w1a1 = w2a2 (B) w1v1 = w2v2 (C) a1v1 = a2v2 (D) a1/v1 = a2/v2

Last Answer : Answer: Option C

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Description : The total extension in a bar, consists of 3 bars of same material, of varying sections is a. P/E(L1/A1+L2/A2+L3/A3) b. P/E(L1A1+L2A2+L3A3) c. PE(L1/A1+L2/A2+L3/A3) d. PE(L1/A1+L2/A2+L3/A3)

Last Answer : a. P/E(L1/A1+L2/A2+L3/A3)

Night blindness is due to deficiency of vitamin: (a) A1 (b) A2 (c) D (d)B complex

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Last Answer : (a) A1

The average marks scored by two Class A1 and A2 students are 120 and 130 respectively. If 8 students are moved from Class A2 to Class A1 and the average marks of the two Class get interchanged. Find the total number of students in two Class put together, if the average marks scored by the 8 students who moved is 150 A) 25 B) 30 C) 35 D) 40

Description : The average marks scored by two Class A1 and A2 students are 120 and 130 respectively. If 8 students are moved from Class A2 to Class A1 and the average marks of the two Class get interchanged. Find the total number ... average marks scored by the 8 students who moved is 150 A) 25 B) 30 C) 35 D) 40

Last Answer :  D)  let the number of students in Class A1 be x and class A2 be y. Total marks scored by the students will be 120x and 130y, the average gets interchanged after moving student from y Thus we get, 130y- ... (x+8) 120x+1200=130x+1040 10x=160 X=16 Thus the total number of students =24+16=40

The primary objective for designing drugs that selectively inhibit COX – 2 is to (a) Decrease the risk of nephrotoxicity (b) Improve anti-inflammatory effectiveness (c) Lower the risk of gastrointestinal toxicity (d) Reduce the cost of treatment of rheumatoid arthritis (e) Selectively decrease thromboxane A2 without effects on other eicosanoids

Description : The primary objective for designing drugs that selectively inhibit COX - 2 is to (a) Decrease the risk of nephrotoxicity (b) Improve anti-inflammatory effectiveness (c) Lower the ... of treatment of rheumatoid arthritis (e) Selectively decrease thromboxane A2 without effects on other eicosanoids

Last Answer : Ans: C

The enzyme catalyzing conversion of androstenedione to testosterone is a (A) Oxygenase (B) Dehydrogenase (C) Isomerase (D) Decarboxylase

Description : The enzyme catalyzing conversion of androstenedione to testosterone is a (A) Oxygenase (B) Dehydrogenase (C) Isomerase (D) Decarboxylase

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Microsomal hydroxylase system contains a (A) Di-oxygenase (B) Mono-oxygenase (C) Both (A) and (B) (D) None of thse

Description : Microsomal hydroxylase system contains a (A) Di-oxygenase (B) Mono-oxygenase (C) Both (A) and (B) (D) None of thse

Last Answer : Answer : B

Isocitrate dehydrogenases is (A) Aerobic dehydrogenase (B) Anaerobic dehydrogenase (C) Hydroperoxidase (D) Oxygenase

Description : Isocitrate dehydrogenases is (A) Aerobic dehydrogenase (B) Anaerobic dehydrogenase (C) Hydroperoxidase (D) Oxygenase

Last Answer : Answer : B

Name the enzyme that acts both as carboxylase at one time and oxygenase at another time. (A) PEP carboxylase (B) RuBP carboxylase (C) Carbonic anyhdrase (D) None of these

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Last Answer : Answer : B

In which of the following types of enzymes, water may be added to a C—C double bond without breaking the bond? (A) Hydrolase (B) Hydratase (C) Hydroxylase (D) Oxygenase

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Last Answer : Answer : A

Tryptophan pyrolase is currently known as (A) Tryptophan deaminase (B) Tryptophan dioxygenase (C) Tryptophan mono oxygenase (D) Tryptophan decarboxylase

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Last Answer : Answer : B

An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase

Description : An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase

Last Answer : Answer : C

β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase (C) Hydroxylase (D) Transferase

Description : β-Carotene, precursor of vitamin A, is oxidatively cleaved by (A) β-Carotene dioxygenase (B) Oxygenase (C) Hydroxylase (D) Transferase

Last Answer : Answer : A

LCAT activity is associated with which of the lipo-protein complex? (A) VLDL (B) Chylomicrones (C) IDL (D) HDL

Description : LCAT activity is associated with which of the lipo-protein complex? (A) VLDL (B) Chylomicrones (C) IDL (D) HDL

Last Answer : Answer : D

Which of the following is a microsomal enzyme inducer? (A) Indomethacin (B) Clofibrate (C) Tolbutamide (D) Glutethamide

Description : Which of the following is a microsomal enzyme inducer? (A) Indomethacin (B) Clofibrate (C) Tolbutamide (D) Glutethamide

Last Answer : Answer : D

Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

Description : Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

Last Answer : Answer : D

Phospholipase C is activated by (A) Gs proteins (B) Gi proteins (C) Gq proteins (D) G12 proteins

Description : Phospholipase C is activated by (A) Gs proteins (B) Gi proteins (C) Gq proteins (D) G12 proteins

Last Answer : Answer : C

Activated phospholipase C acts on (A) Phosphatidyl inositol-4, 5-biphosphate (B) Inositol-1, 4, 5-triphosphate (C) Protein kinase C (D) Pl-3 kinase

Description : Activated phospholipase C acts on (A) Phosphatidyl inositol-4, 5-biphosphate (B) Inositol-1, 4, 5-triphosphate (C) Protein kinase C (D) Pl-3 kinase

Last Answer : Answer : A

Binding of insulin to its receptor activates (A) Adenylate cyclase (B) Guanylate cyclase (C) Phospholipase C (D) Tyrosine kinase

Description : Binding of insulin to its receptor activates (A) Adenylate cyclase (B) Guanylate cyclase (C) Phospholipase C (D) Tyrosine kinase

Last Answer : Answer : D

Phospholipase C attacks the ester bond liberating 1, 2-diacylglycerol and a phosphoryl base at position (A) 1 (B) 2 (C) Both (A) and (B) (D) 3

Description : Phospholipase C attacks the ester bond liberating 1, 2-diacylglycerol and a phosphoryl base at position (A) 1 (B) 2 (C) Both (A) and (B) (D) 3

Last Answer : Answer : D

Apolipoprotein C-II is an activator of (A) Lecithin cholesterola acyl transferase (B) Phospholipase C (C) Extrahepatic lipoprotein lipase (D) Hepatic lipoprotein lipase

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Last Answer : Answer : C