Description : Prostaglandins decrease all of the following except (A) Gastric acid secretion (B) Blood pressure (C) Uterine contraction (D) Platelet aggregation
Last Answer : Answer : C
Description : Prostaglandins lower camp in (A) Adipose tissue (B) Lungs (C) Platelets (D) Adenohypophysis
Last Answer : Answer : A
Description : Epinephrine increases all of the following except (A) Glycogenolysis in muscles (B) Lipolysis in adipose tissue (C) Gluconeogenesis in muscles (D) Glucagon secretion
Description : Leukotrienes cause (A) Increase in capillary permeability (B) Aggregation of platelets (C) Bronchodilatation (D) None of these
Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue
Last Answer : Answer : D
Description : Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue
Last Answer : . Facilitation of neoglucogenesis by liver
Description : The metabolic actions of adrenaline include the following except: A. Glycogenolysis in liver and muscle B. Inhibition of neoglucogenesis in liver C. Lipolysis in adipose tissue D. Release of potassium from liver followed by its uptake
Last Answer : B. Inhibition of neoglucogenesis in liver
Description : One of the important functions of prostacyclins is (A) Inhibition of platelet aggregation (B) Contraction of uterus (C) Decrease of gastric secretion (D) Relieving osthma
Description : The primary mechanism by which prostaglandins promote ulcer healing is: A. Inhibition of gastric acid secretion B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa C. Increased bicarbonate secretion in gastric juice D. Increased turnover of gastric mucosal cell
Last Answer : B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa
Description : Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and ... conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.
Last Answer : Answer: ABCD DISCUSSION: Hemostasis requires the interaction of platelets with the exposed subendothelial structures at the site of injury followed by aggregation of more platelets in that area. ... form a stable clot that incorporates the platelet plug and fibrin thrombus into a stable clot
Description : Propranolol does not block the following action of adrenaline: A. Bronchodilatation B. Lipolysis C. Muscle tremor D. Mydriasis
Last Answer : D. Mydriasis
Description : Which of the following statement(s) is/are correct concerning the immunoinflammatory response to shock? a. The anaphylactoxins, C3a and C5a, are products of activation of only the classical pathway ... effects d. Platelet-activating factor can be released by both circulating and fixed tissue cells
Last Answer : Answer: d Inflammatory mediators have recently been recognized as playing a significant role in the clinical manifestations and progression of shock and the development ... increased pulmonary vascular resistance, bronchoconstriction, peripheral vasodilatation, and increased vascular permeability
Description : Six months after beginning atorvastatin, the patient's total and LDL cholesterol concentrations remained above normal and he continued to have anginal attacks despite good adherence to his antianginal ... Increased endocytosis of HDL by the liver (e) Increased lipid hydrolysis by lipoprotein lipase
Last Answer : Ans: C
Description : Laboratory monitoring of coagulation and anticoagulation includes testing of platelet function. Which of the following statements is/are true concerning tests of platelet function? a. A ... platelet aggregation should be part of the standard preoperative evaluation of patients using aspirin
Last Answer : Answer: a, c Tests of platelet function include peripheral platelet counts, bleeding times, and platelet aggregation. Usually, a platelet count of 50,000/mL or more ensures adequate hemostasis ... is not available in most laboratories, probably because of the observer-dependent nature of the test
Description : Which of the following statement(s) is/are true concerning heparin-associated thrombocytopenia? a. Heparin-associated thrombocytopenia occurs only in the face of over anticoagulation with heparin b. ... d. Heparin-associated thrombocytopenia may be seen within hours of initiation of heparin therapy
Last Answer : Answer: b, c Heparin-associated thrombocytopenia occurs in 0.6% to 30% of patients who receive heparin, although severe thrombocytopenia (platelet counts less than 100,000) is seen in ... as coating on pulmonary artery catheters or low rate infusion into arterial catheters may cause this syndrome
Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors
Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation
Description : The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab
Last Answer : C. Dipyridamole
Description : Glycerol-3-phosphate for the synthesis of triglycerides in adipose tissue is derived from (A) Phosphatidic acid (B) Diacylglycerol (C) Glycerol (D) Glucose
Description : Glycerol released from adipose tissue by hydrolysis of triglycerides is mainly (A) Taken up by liver (B) Taken up by extrahepatic tissues (C) Reutilised in adipose tissue (D) Excreted from the body FATS AND FATTY ACID METABOLISM 85
Description : An increase in the osmolality of extracellular compartment will (A) Inhibit ADH secretion (B) Stimulate ADH secretion (C) Cause no change in ADH secretion (D) Stimulate the volume and osmoreceptor and inhibit ADH secretion
Last Answer : Answer : B
Description : Leukotrienes: 1) Are formed from the cyclooxygenase pathway 2) Are synthesized by fibroblasts 3) Decrease vascular permeability 4) Leukotriene D4 has been identified as SRS-A which causes bronchial wall smooth muscle relaxation 5) Stimulate mucus secretion
Last Answer : Answers-5 Leukotrienes are synthesized by leucocytes.They are mediators of allergic reaction. They increase vascular permeability and attract neutrophils and eosinophils to inflammatory sites. ... stimulate mucus production, an important consideration in the pathophysiology of bronchial asthma.
Description : The actions of platelet activating factor include the following except: A. Increased capillary permeability B. Bronchodilatation C. Vasodilatation D. Erosion of gastric mucosa
Last Answer : B. Bronchodilatation
Description : Typical results of beta-receptor activation include which one of the following? (a) Hypoglycemia (b) Lipolysis (c) Glycogen synthesis (d) Decreased skeletal muscle tremor (e) Decreased rennin secretion
Last Answer : Ans: B
Description : The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin A. Histamine H2 blockers B. Anticholinergics C. Proton pump inhibitors D. Prostaglandins
Last Answer : B. Anticholinergics
Description : All of the following are true regarding platelet-activating factor (PAF) EXCEPT: C A. Induces platelet aggregation B. Stimulates platelet secretion C. It is a preformed molecule present in various cells D. None of these
Last Answer : It is a preformed molecule present in various cells
Description : In the normal resting state of human most of the blood glucose burnt as fuel is consumed by (A) Liver (B) Brain (C) Adipose tissue (D) Muscles
Description : Brown adipose tissue is (A) A prominent tissue in human (B) Characterised by high content of mitochondria (C) Associated with high activity of ATP synthase (D) Characterised by low content of cytochromes
Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase
Description : The output of free fatty acids from adipose tissue is reduced by (A) Insulin (B) Glucagon (C) Growth hormone (D) Epinephrine
Description : The enzyme glycerol kinase is low activity in (A) Liver (B) Kidney (C) Intestine (D) Adipose tissue
Description : α-Oxidation i.e., the removal of one carbon at a time from the carboxyl end of the molecule has been detected in (A) Brain tissue (B) Liver (C) Adipose tissue (D) Intestine
Description : Galactose is readily converted to glucose in (A) Liver (B) Intestine (C) Kidney (D) Adipose tissue
Description : Galactose is synthesized from glucose in (A) Mammary gland (B) Intestine (C) Kidney (D) Adipose tissue
Description : The enzyme glucose 6-phosphatase is present in (A) Liver (B) Muscle (C) Adipose tissue (D) Brain
Description : In the normal resting state of humans, most of the blood glucose burned as fuel is consumed by (A) Liver (B) Adipose tissue (C) Muscle (D) Brain
Description : Vitamin A is stored in the body in (A) Liver (B) Adipose tissue (C) Reticuloendothelial cells (D) All of these
Description : Calcitriol synthesis involves (A) Both liver and kidney (B) Intestine (C) Adipose tissue (D) Muscle
Description : Brown adipose tissue is characterized by which of the following? (A) Present in large quantities in adult humans (B) Mitochondrial content higher than white adipose tissue (C) Oxidation and phosphorylation are tightly coupled (D) Absent in hibernating animals
Description : Neutral fat is stored in (A) Liver (B) Pancreas (C) Adipose tissue (D) Brain
Description : When the stired triacylglycerol is lipolysed in the adipose tissue blood levels of _____ increased. (A) FFA only (B) Glycerol only (C) Free fatty acids (FFA) and Glycerol (D) Triacyl glycero
Description : Adipose tissue which is a store house for triacyl glycerol synthesis the same using (A) The glycerol released by hydrolysis of triacyl glycerol (B) The glycerol-3-phosphate obtained in the metabolism of glucose (C) 2-phosphoglycerate (D) 3-phosphoglycerate
Description : Esterification of cholesterol occurs mainly in (A) Adipose tissue (B) Liver (C) Muscles (D) Kidneys
Description : Free fatty acids released from adipose tissue are transported in blood by (A) Albumin (B) VLDL (C) LDL (D) HDL
Description : All the following statements about brown adipose tissue are true except (A) It is rich in cytochromes (B) It oxidizes glucose and fatty acids (C) Oxidation and phosphorylation are tightly coupled in it (D) Dinitrophenol has no effect on it
Description : Release of free fatty acids from adipose tissue is increased by all of the following except (A) Glucagon (B) Epinephrine (C) Growth hormone (D) Insulin
Description : α-Oxidation of fatty acids occurs mainly in (A) Liver (B) Brain (C) Muscles (D) Adipose tissue
Description : Adipose tissue lacks (A) Hormone-sensitive lipase (B) Glycerol kinase (C) cAMP-dependent protein kinase (D) Glycerol-3-phosphate dehydrogenase
Description : Free glycerol cannot be used for triglyceride synthesis in (A) Liver (B) Kidney (C) Intestine (D) Adipose tissue
Description : In adipose tissue, glycerol-3-phosphate required for the synthesis of triglycerides comes mainly from (A) Hydrolysis of pre-existing triglycerides (B) Hydrolysis of phospholipids (C) Dihydroxyacetone phosphate formed in glycolysis (D) Free glycerol