For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate

1 Answer

Answer :

Answer : A

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Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate

Last Answer : Answer : A

Description : The initial step of the citric acid cycle is (A) Conversion of pyruvate to acetyl-CoA (B) Condensation of acetyl-CoA with oxaloacetate (C) Conversion of citrate to isocitrate (D) Formation of α -ketoglutarate catalysed by isocitrate dehydrogenase

Last Answer : Answer : B

Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Last Answer : Answer : A

Description : The reaction of Kreb’s cycle which does not require cofactor of vitamin B group is (A) Citrate isocitrate (B) α -Ketoglutarate succinate (C) Malate oxaloacetate (D) Succinate fumarate

Last Answer : Answer : A

Description : The example of generation of a high energy phosphate at the substrate level in the citric acid cycle is the reaction: (A) Isocitrate α-Ketoglutarate (B) Succinate α-fumarate (C) Malate α-oxaloacetate (D) Succinyl CoA α-Succinate

Last Answer : Answer : D

Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex

Last Answer : Answer : B

Description : A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP

Last Answer : Answer : A

Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP

Last Answer : Answer : A

Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase

Last Answer : Answer : B

Description : A carrier molecule in the citric acid cycle is (A) Acetyl-CoA (B) Citrate (C) Oxaloacetate (D) Malate

Last Answer : Answer : C

Description : NADPH required for fatty acid synthesis can come from (A) Hexose monophosphate shunt (B) Oxidative decarboxylation of malate (C) Extramitochondrial oxidation of isocitrate (D) All of these

Last Answer : Answer : D

Description : Thiamine is essential for (A) Pyruvate dehydrogenase (B) Isocitrate dehydrogenase (C) Succinate dehydrogenase (D) Acetyl CoA synthetase ENZYMES 165

Last Answer : Answer : B

Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

Last Answer : Answer : D

Description : Fluoroacetate inhibits the reaction of citric acid cycle: (A) Isocitrate α-Ketoglutarate (B) Fumarate α-Malate (C) Citrate α-cis-aconitate (D) Succinate α-fumarate

Last Answer : Answer : C

Description : Which of the following metabolite integrates glucose and fatty acid metabolism? (A) Acetyl CoA (B) Pyruvate (C) Citrate (D) Lactate

Last Answer : A

Description : The metabolism of protein is integrated with that of carbohydrate and fat through (A) Oxaloacetate (B) Citrate (C) Isocitrate (D) Malate

Last Answer : Answer : A

Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

Last Answer : Answer : D

Description : An aneplerotic reaction which sustains the availability of oxaloacetate is the carboxylation of (A) Glutamate (B) Pyruvate (C) Citrate (D) Succinate

Last Answer : B

Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Last Answer : Answer : C

Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

Last Answer : Answer : A

Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these

Last Answer : Answer : D

Description : Acetyl CoA is not used for the synthesis of (A) Fatty acid (B) Cholesterol (C) Pyruvic acid (D) Citric acid

Last Answer : C

Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?

Last Answer : ATP citrate lyase.

Description : Before pyruvic acid enters the TCA cycle it must be converted to (A) Acetyl CoA (B) Lactate (C) α-ketoglutarate (D) Citrate

Last Answer : A

Description : The substance which may be considered to play a catalytic role in citric acid cycle is (A) Oxaloacetate (B) Isocitrate (C) Malate (D) Fumarate

Last Answer : Answer : A

Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Last Answer : Answer : B

Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates

Last Answer : Answer : C

Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these

Last Answer : Answer : D

Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

Last Answer : Answer : A

Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin

Last Answer : Answer : B

Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP

Last Answer : A

Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue

Last Answer : Answer : D

Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

Last Answer : Answer : D

Description : Acetyl CoA carboxylase is activated by (A) Citrate (B) Insulin (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Description : The formation of citrate from oxalo acetate and acetyl CoA is (A) Oxidation (B) Reduction (C) Condensation (D) Hydrolysis CARBOHYDRATES AND CARBOHYDRATE METABOLISM 17

Last Answer : C

Description : Extramitochondrial synthesis of fatty acids occurs in (A) Mammary glands (B) Lungs (C) Brain (D) All of these

Last Answer : Answer : D

Description : Connecting link between glycolysis and Krebs’ cycle before pyruvate entering Krebs’ cycle is changed to (a) oxaloacetate (b) PEP (c) pyruvate (d) acetyl CoA.

Last Answer : (d) acetyl CoA.

Description : Among citric acid cycle enzymes, a flavoprotein is (A) Malate (B) Fumarase (C) Succinate dehrogenase (D) Isocitrate dehrogenase

Last Answer : Answer : C

Description : The carrier of the citric acid cycle is (A) Succinate (B) Fumarate (C) Malate (D) Oxaloacetate

Last Answer : D

Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103

Last Answer : Answer : A

Description : β-Oxidation of odd-carbon fatty acid chain produces (A) Succinyl CoA (B) Propionyl CoA (C) Acetyl CoA (D) Malonyl CoA

Last Answer : Answer : D

Description : As a result of each oxidation a long chain fatty acid is cleaved to give (A) An acid with 3-carbon less and propionyl CoA (B) An acid with 2-carbon less and acetyl CoA (C) An acid with 2-carbon less and acetyl CoA (D) An acid with 4-carbon and butyryl CoA

Last Answer : Answer : B

Description : All long chain fatty acids with even number of carbon atoms are oxidized to a pool of _________ by β-oxidation. (A) CO2 (B) Propionic acid (C) Acetic acid (D) Acetyl CoA

Last Answer : Answer : D

Description : An enzyme of the citric acid cycle also found outside the mitochondria is (A) Isocitrate dehydrogenase (B) Citrate synthetase (C) α-Ketoglutarate dehydrogenase (D) Malate dehydrogenase

Last Answer : Answer : C

Description : In synthesis of Triglyceride from α-Glycero phosphate and acetyl CoA, the first intermediate formed is (A) β-diacyl glycerol (B) Acyl carnitine (C) Monoacyl glycerol(D) Phosphatidic acid

Last Answer : Answer : D

Description : A compound serving a link between citric acid cycle and urea cycle is (A) Malate (B) Citrate (C) Succinate (D) Fumarate

Last Answer : Answer : D

Description : Calcium is required for the activation of the enzyme: (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase

Last Answer : Answer : D

Description : Malonate is an inhibitor of (A) Malate dehydrogenase (B) α-Ketoglutarate dehydrogenase (C) Succinate dehydrogenase (D) Isocitrate dehydrogenase

Last Answer : Answer : C

Description : With the exception of glycine all amino acids found in protein are (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase

Last Answer : Answer : B

Description : Substrate level phosphorylation in TCA cycle is in step: (A) Isocitrate dehydrogenase (B) Malate dehydrogenase (C) Aconitase (D) Succinate thiokinase

Last Answer : D