De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by insulin (C) NADH is required in synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis

De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by insulin (C) NADH is required in synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis
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All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids (C) It is required for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Last Answer : Answer : B

Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

Last Answer : Answer : D

De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes

Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes

Last Answer : Answer : B

De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes

Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes

Last Answer : Answer : B

De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP

Description : De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP

Last Answer : Answer : D

Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?

Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?

Last Answer : ATP citrate lyase.

De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these

Description : De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these

Last Answer : Answer : A

Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

Last Answer : Answer : D

Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP

Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP

Last Answer : Answer : A

C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these

Description : C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these

Last Answer : Answer : B

The synthesis of glucose from pyruvate by gluconeogenesis (A) Requires the participation of biotin (B) Occurs exclusively in the cytosol (C) Is inhibited by elevated level of insulin (D) Requires oxidation/reduction of FAD

Description : The synthesis of glucose from pyruvate by gluconeogenesis (A) Requires the participation of biotin (B) Occurs exclusively in the cytosol (C) Is inhibited by elevated level of insulin (D) Requires oxidation/reduction of FAD

Last Answer : A

During each cycle of β-oxidation of fatty acid, all the following compounds are generated except (A) NADH (B) H2O (C) FAD (D) Acyl CoA

Description : During each cycle of β-oxidation of fatty acid, all the following compounds are generated except (A) NADH (B) H2O (C) FAD (D) Acyl CoA

Last Answer : Answer : B

Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

Last Answer : Answer : A

Oxidation of fatty acids occurs (A) In the cytosol (B) In the matrix of mitochondria (C) On inner mitochondrial membrane (D) On the microsomes

Description : Oxidation of fatty acids occurs (A) In the cytosol (B) In the matrix of mitochondria (C) On inner mitochondrial membrane (D) On the microsomes

Last Answer : Answer : B

While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Last Answer : Answer : A

The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms

Description : The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms

Last Answer : Answer : A

β-oxidation of fatty acids is inhibited by (A) NADPH (B) Acetyl CoA (C) Malonyl CoA (D) None of these

Description : β-oxidation of fatty acids is inhibited by (A) NADPH (B) Acetyl CoA (C) Malonyl CoA (D) None of these

Last Answer : Answer : C

In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C) In the conversion of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates

Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates

Last Answer : Answer : C

Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Last Answer : Answer : C

Long chain fatty acids are first activated to acetyl-CoA in (A) Cytosol (B) Microsomes (C) Nucleus (D) Mitochondria

Description : Long chain fatty acids are first activated to acetyl-CoA in (A) Cytosol (B) Microsomes (C) Nucleus (D) Mitochondria

Last Answer : Answer : A

In β-Oxidation of fatty acids, which of the following are utilized as coenzymes? (A) NAD+ and NADP+ (B) FADH2 and NADH + H+ (C) FAD and FMN (D) FAD and NAD+

Description : In β-Oxidation of fatty acids, which of the following are utilized as coenzymes? (A) NAD+ and NADP+ (B) FADH2 and NADH + H+ (C) FAD and FMN (D) FAD and NAD+

Last Answer : Answer : D

A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP

Description : A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP

Last Answer : Answer : A

One functional sub-unit of multi-enzyme complex for de novo synthesis of fatty acids contains (A) One —SH group (B) Two —SH groups (C) Three —SH groups (D) Four —SH groups FATS AND FATTY ACID METABOLISM 87

Description : One functional sub-unit of multi-enzyme complex for de novo synthesis of fatty acids contains (A) One —SH group (B) Two —SH groups (C) Three —SH groups (D) Four —SH groups FATS AND FATTY ACID METABOLISM 87

Last Answer : Answer : B

De novo synthesis of fatty acids is catalysed by a multi-enzyme complex which contains (A) One-SH group (B) Two-SH groups (C) Three-SH groups (D) Four-SH groups

Description : De novo synthesis of fatty acids is catalysed by a multi-enzyme complex which contains (A) One-SH group (B) Two-SH groups (C) Three-SH groups (D) Four-SH groups

Last Answer : Answer : D

In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased

Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased

Last Answer : Answer : B

β-Oxidation of fatty acids requires all the following coenzymes except (A) CoA (B) FAD (C) NAD (D) NADP

Description : β-Oxidation of fatty acids requires all the following coenzymes except (A) CoA (B) FAD (C) NAD (D) NADP

Last Answer : Answer : D

The main pathway for denovo synthesis of fatty acids occur in (A) Cytosol (B) Mitochondria (C) Microsomes (D) Nucleus

Description : The main pathway for denovo synthesis of fatty acids occur in (A) Cytosol (B) Mitochondria (C) Microsomes (D) Nucleus

Last Answer : Answer : A

β-Oxidation of odd-carbon fatty acid chain produces (A) Succinyl CoA (B) Propionyl CoA (C) Acetyl CoA (D) Malonyl CoA

Description : β-Oxidation of odd-carbon fatty acid chain produces (A) Succinyl CoA (B) Propionyl CoA (C) Acetyl CoA (D) Malonyl CoA

Last Answer : Answer : D

Fatty acids with odd number of carbon atoms yield acetyl-CoA and a molecule of (A) Succinyl-CoA (B) Propionyl-CoA (C) Malonyl-CoA (D) Acetoacetyl-CoA

Description : Fatty acids with odd number of carbon atoms yield acetyl-CoA and a molecule of (A) Succinyl-CoA (B) Propionyl-CoA (C) Malonyl-CoA (D) Acetoacetyl-CoA

Last Answer : Answer : B

During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103

Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103

Last Answer : Answer : A

Nucleotides required for the synthesis of nucleic acids can be obtained from (A) Dietary nucleic acids and nucleotides (B) De novo synthesis (C) Salvage of pre-existing bases and nucleosides (D) De novo synthesis and salvage

Description : Nucleotides required for the synthesis of nucleic acids can be obtained from (A) Dietary nucleic acids and nucleotides (B) De novo synthesis (C) Salvage of pre-existing bases and nucleosides (D) De novo synthesis and salvage

Last Answer : Answer : D

The synthesis of 3-hydroxy-3-methylglutaryl-CoA can occur (A) Only in mitochondria of all mammalian tissues (B) Only in the cytosol of all mammalian tissue (C) In both cytosol and mitochondria (D) In lysosomes

Description : The synthesis of 3-hydroxy-3-methylglutaryl-CoA can occur (A) Only in mitochondria of all mammalian tissues (B) Only in the cytosol of all mammalian tissue (C) In both cytosol and mitochondria (D) In lysosomes

Last Answer : Answer : C

In β−oxidation of fatty acids which of the following are utilized as co-enzymes? (A) NAD+ and NADP+ (B) FAD H2 and NADH + H+ (C) FAD and FMN (D) FAD and NAD+

Description : In β−oxidation of fatty acids which of the following are utilized as co-enzymes? (A) NAD+ and NADP+ (B) FAD H2 and NADH + H+ (C) FAD and FMN (D) FAD and NAD+

Last Answer : Answer : D

Carboxylation of acetyl—CoA to malonyl — CoA takes place in presence of (A) FAD+ (B) Biotin (C) NAD+ (D) NADP+

Description : Carboxylation of acetyl—CoA to malonyl — CoA takes place in presence of (A) FAD+ (B) Biotin (C) NAD+ (D) NADP+

Last Answer : Answer : C

Long chain fatty acids are first activated to acyl CoA in the (A) Cytosol (B) Mitochodria (C) Ribosomes (D) Microsome

Description : Long chain fatty acids are first activated to acyl CoA in the (A) Cytosol (B) Mitochodria (C) Ribosomes (D) Microsome

Last Answer : Answer : A

Carbamoyl phosphate required for urea synthesis is formed in (A) Cytosol (B) Mitochondria (C) Both (A) and (B) (D) None of these

Description : Carbamoyl phosphate required for urea synthesis is formed in (A) Cytosol (B) Mitochondria (C) Both (A) and (B) (D) None of these

Last Answer : Answer : B

What is the rate limiting enzyme of de novo synthesis of fatty acid?

Description : What is the rate limiting enzyme of de novo synthesis of fatty acid?

Last Answer : Acetyl CoA carboxylase.

Fatty acids are activated to acyl CoA by the enzyme thiokinase: (A) NAD+ (B) NADP+ (C) CoA (D) FAD+

Description : Fatty acids are activated to acyl CoA by the enzyme thiokinase: (A) NAD+ (B) NADP+ (C) CoA (D) FAD+

Last Answer : Answer : C

The major site for elongation of medium chain fatty acids is (A) Mitochondria (B) Cytosol (C) Microsomes (D) All of these

Description : The major site for elongation of medium chain fatty acids is (A) Mitochondria (B) Cytosol (C) Microsomes (D) All of these

Last Answer : Answer : C

What is the sub cellular site for the βoxidation of fatty acids? (A) Nucleus (B) Mitochondria (C) Lysosome (D) Cytosol

Description : What is the sub cellular site for the βoxidation of fatty acids? (A) Nucleus (B) Mitochondria (C) Lysosome (D) Cytosol

Last Answer : Answer : B

During synthesis of porphyrins, synthesis of δ-amino levulinic acid occurs in (A) Mitochondria (B) Cytosol (C) Both in mitochondria and cytosol (D) Ribosomes

Description : During synthesis of porphyrins, synthesis of δ-amino levulinic acid occurs in (A) Mitochondria (B) Cytosol (C) Both in mitochondria and cytosol (D) Ribosomes

Last Answer : Answer : A

The acetyl CoA formed on β-oxidation of all long chain fatty acids is metabolized under normal circumstances to (A) CO2 and water (B) Cholesterol (C) Fatty acids (D) Ketone bodies

Description : The acetyl CoA formed on β-oxidation of all long chain fatty acids is metabolized under normal circumstances to (A) CO2 and water (B) Cholesterol (C) Fatty acids (D) Ketone bodies

Last Answer : Answer : A

Propionyl CoA formed oxidation of fatty acids having an odd number of carbon atoms is converted into (A) Acetyl CoA (B) Acetoacetyl CoA (C) D-Methylmalonyl CoA (D) Butyryl CoA

Description : Propionyl CoA formed oxidation of fatty acids having an odd number of carbon atoms is converted into (A) Acetyl CoA (B) Acetoacetyl CoA (C) D-Methylmalonyl CoA (D) Butyryl CoA

Last Answer : Answer : C

Propionyl CoA is formed on oxidation of (A) Monounsaturated fatty acids (B) Polyunsaturated fatty acids (C) Fatty acids with odd number of carbon atoms (D) None of these FATS AND FATTY ACID METABOLISM 83

Description : Propionyl CoA is formed on oxidation of (A) Monounsaturated fatty acids (B) Polyunsaturated fatty acids (C) Fatty acids with odd number of carbon atoms (D) None of these FATS AND FATTY ACID METABOLISM 83

Last Answer : Answer : C

Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

Last Answer : Answer : A

During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate

Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate

Last Answer : Answer : B

A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these

Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these

Last Answer : Answer : D

All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be due to increased activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it

Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it

Last Answer : Answer : C

In the biosynthesis of heme, condensation between succinyl CoA and glycine requires (A) NAD+ (B) FAD (C) NADH + H+ (D) B6-phosphate

Description : In the biosynthesis of heme, condensation between succinyl CoA and glycine requires (A) NAD+ (B) FAD (C) NADH + H+ (D) B6-phosphate

Last Answer : Answer : D

Conversion of fatty acyl-CoA to an acylCoA derivative having 2 more carbon atoms involves as acetyl donar: (A) Acetyl-CoA (B) Succinyl-CoA (C) Propionyl-CoA (D) Malonyl-CoA

Description : Conversion of fatty acyl-CoA to an acylCoA derivative having 2 more carbon atoms involves as acetyl donar: (A) Acetyl-CoA (B) Succinyl-CoA (C) Propionyl-CoA (D) Malonyl-CoA

Last Answer : Answer : D