Prothrombin is synthesised in (A) Erythrocytes (B) Reticulo-endothelial cells (C) Liver (D) Kidneys

Prothrombin is synthesised in (A) Erythrocytes (B) Reticulo-endothelial cells (C) Liver (D) Kidneys
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Glycolysis is anaerobic in (A) Liver (B) Brain (C) Kidneys (D) Erythrocytes

Description : Glycolysis is anaerobic in (A) Liver (B) Brain (C) Kidneys (D) Erythrocytes

Last Answer : Answer : D

The principal nitrogenous excretory compound in humans is synthesised (a) in kidneys but eliminated mostly through liver (b) in kidneys as well as eliminated by kidneys (c) in liver and also eliminated by the same through bile (d) in the liver, but eliminated mostly through kidneys.

Description : The principal nitrogenous excretory compound in humans is synthesised (a) in kidneys but eliminated mostly through liver (b) in kidneys as well as eliminated by kidneys (c) in liver and also eliminated by the same through bile (d) in the liver, but eliminated mostly through kidneys.

Last Answer : (d) in the liver, but eliminated mostly through kidneys.

All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised due to increased release of the enzyme from liver cells (C) Bile salts may enter systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Last Answer : Answer : B

Glucose is the only source of energy for (A) Myocardium (B) Kidneys (C) Erythrocytes (D) Thrombocytes

Description : Glucose is the only source of energy for (A) Myocardium (B) Kidneys (C) Erythrocytes (D) Thrombocytes

Last Answer : Answer : C

Prothrombin , albumin and fibrinogen are synthesised by

Description : Prothrombin , albumin and fibrinogen are synthesised by

Last Answer : Prothrombin , albumin and fibrinogen are synthesised by A. Pancreas B. Bone marrow C. Spleen D. Liver

Angiotensinogen is a protein produced and secreted by (a) juxtaglomerular (JG) cells (b) macula densa cells (c) endothelial cells (cells lining the blood vessels) (d) liver cells.

Description : Angiotensinogen is a protein produced and secreted by (a) juxtaglomerular (JG) cells (b) macula densa cells (c) endothelial cells (cells lining the blood vessels) (d) liver cells.

Last Answer : d) liver cells.

Schizont stage of Plasmodium occurs in human (a) erythrocytes (b) liver cells (c) erythrocytes and liver cells (d) erythrocytes, liver cells and spleen cells

Description : Schizont stage of Plasmodium occurs in human (a) erythrocytes (b) liver cells (c) erythrocytes and liver cells (d) erythrocytes, liver cells and spleen cells

Last Answer : (c) erythrocytes and liver cells

Prothrombin time is prolonged in (A) Vitamin K deficiency (B) Liver damage (C) Both (A) and (B) (D) None of these

Description : Prothrombin time is prolonged in (A) Vitamin K deficiency (B) Liver damage (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

A test to evaluate detoxifying function of liver is (A) Serum albumin: globulin ratio (B) Galactose tolerance test (C) Hippuric acid test (D) Prothrombin time

Description : A test to evaluate detoxifying function of liver is (A) Serum albumin: globulin ratio (B) Galactose tolerance test (C) Hippuric acid test (D) Prothrombin time

Last Answer : Answer : C

Prothrombin time remains prolonged even after parenterals administration of vitamin K in (A) Haemolytic jaundice (B) Liver damage (C) Biliary obstruction (D) Steatorrhoea

Description : Prothrombin time remains prolonged even after parenterals administration of vitamin K in (A) Haemolytic jaundice (B) Liver damage (C) Biliary obstruction (D) Steatorrhoea

Last Answer : Answer : B

In parenhymatous liver disease the prothrombin time (A) Remains normal (B) Increases (C) Decreases (D) Responds to Vit K

Description : In parenhymatous liver disease the prothrombin time (A) Remains normal (B) Increases (C) Decreases (D) Responds to Vit K

Last Answer : Answer : B

Glycophorin is present in cell membranes of (A) Erythrocytes (B) Platelets (C) Neutrophils (D) Liver

Description : Glycophorin is present in cell membranes of (A) Erythrocytes (B) Platelets (C) Neutrophils (D) Liver

Last Answer : Answer : A

HMP shunt is present in (A) Erythrocytes (B) Liver (C) Testes (D) All of these

Description : HMP shunt is present in (A) Erythrocytes (B) Liver (C) Testes (D) All of these

Last Answer : Answer : D

Rapoport-Luebering cycle is located in (A) Liver (B) Muscles (C) Brain (D) Erythrocytes

Description : Rapoport-Luebering cycle is located in (A) Liver (B) Muscles (C) Brain (D) Erythrocytes

Last Answer : Answer : D

The structure which appears to be the only organ to add significant quantities of ketone bodies to the blood is (A) Brain (B) Erythrocytes (C) Liver (D) Skeletal muscle

Description : The structure which appears to be the only organ to add significant quantities of ketone bodies to the blood is (A) Brain (B) Erythrocytes (C) Liver (D) Skeletal muscle

Last Answer : Answer : C

During starvation, ketone bodies are used as a fuel by (A) Erythrocytes (B) Brain (C) Liver (D) All of these

Description : During starvation, ketone bodies are used as a fuel by (A) Erythrocytes (B) Brain (C) Liver (D) All of these

Last Answer : B

All the following statements about transcortin are true except (A) It is synthesised in liver (B) It transports glucocorticoids (C) It transports aldosterone (D) It transports progesterone

Description : All the following statements about transcortin are true except (A) It is synthesised in liver (B) It transports glucocorticoids (C) It transports aldosterone (D) It transports progesterone

Last Answer : Answer : C

Apolipoprotein B-100 is synthesised in (A) Adipose tissue (B) Liver (C) Intestine (D) Liver and intestine

Description : Apolipoprotein B-100 is synthesised in (A) Adipose tissue (B) Liver (C) Intestine (D) Liver and intestine

Last Answer : Answer : B

Surplus red blood cells, needed to meet an emergency, are MAINLY stored in what organ of the human body? Is it the: a) pancreas b) spleen c) liver d) kidneys

Description : Surplus red blood cells, needed to meet an emergency, are MAINLY stored in what organ of the human body? Is it the: a) pancreas b) spleen c) liver d) kidneys

Last Answer : ANSWER: B -- spleen

Dietary purines are catabolised in (A) Liver (B) Kidneys (C) Intesitnal mucosa (D) All of these

Description : Dietary purines are catabolised in (A) Liver (B) Kidneys (C) Intesitnal mucosa (D) All of these

Last Answer : Answer : C

Total synthesis of creatine can be done by (A) Liver (B) Kidneys (C) Pancreas (D) Heart

Description : Total synthesis of creatine can be done by (A) Liver (B) Kidneys (C) Pancreas (D) Heart

Last Answer : Answer : C

Hyper insulinism can cause coma since (A) The chief nutrient for the brain is glucose (B) The chief nutrient for the heart is glucose (C) The glucostatic role of the liver is damaged (D) The kidneys are damaged

Description : Hyper insulinism can cause coma since (A) The chief nutrient for the brain is glucose (B) The chief nutrient for the heart is glucose (C) The glucostatic role of the liver is damaged (D) The kidneys are damaged

Last Answer : Answer : A

Gluconeogenesis does not occur in (A) Brain (B) Kidneys (C) Muscles (D) Liver

Description : Gluconeogenesis does not occur in (A) Brain (B) Kidneys (C) Muscles (D) Liver

Last Answer : Answer : C

Glucose-1-phosphate liberated from glycogen cannot be converted into free glucose in (A) Liver (B) Kidneys (C) Muscles (D) Brain

Description : Glucose-1-phosphate liberated from glycogen cannot be converted into free glucose in (A) Liver (B) Kidneys (C) Muscles (D) Brain

Last Answer : Answer : C

25-hydroxylation of Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestines (D) Pancreas

Description : 25-hydroxylation of Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestines (D) Pancreas

Last Answer : Answer : A

1-hydroxylation of 25-hydroxy Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Description : 1-hydroxylation of 25-hydroxy Vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Last Answer : Answer : B

25-hydroxylation of vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Description : 25-hydroxylation of vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Last Answer : Answer : A

1-hydroxylation of 25-OH vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Description : 1-hydroxylation of 25-OH vitamin D3 takes place in (A) Liver (B) Kidneys (C) Intestine (D) Pancreas

Last Answer : Answer : B

25-Hydroxylation of vitamin D occurs in (A) Skin (B) Liver (C) Kidneys (D) Intestinal mucosa

Description : 25-Hydroxylation of vitamin D occurs in (A) Skin (B) Liver (C) Kidneys (D) Intestinal mucosa

Last Answer : Answer : B

Acetoacetic acid and β-OH butyric acid are formed as (A) Kidneys (B) Heart (C) Liver (D) Intestine

Description : Acetoacetic acid and β-OH butyric acid are formed as (A) Kidneys (B) Heart (C) Liver (D) Intestine

Last Answer : Answer : C

Esterification of cholesterol occurs mainly in (A) Adipose tissue (B) Liver (C) Muscles (D) Kidneys

Description : Esterification of cholesterol occurs mainly in (A) Adipose tissue (B) Liver (C) Muscles (D) Kidneys

Last Answer : Answer : B

The major site of urea synthesis is (A) Brain (B) Kidneys (C) Liver (D) Muscles

Description : The major site of urea synthesis is (A) Brain (B) Kidneys (C) Liver (D) Muscles

Last Answer : Answer : B

The normal resting state of humans, most of the blood glucose burnt as “fuel” is consumed by (A) Liver (B) Brain (C) Kidneys (D) Adipose tissue

Description : The normal resting state of humans, most of the blood glucose burnt as “fuel” is consumed by (A) Liver (B) Brain (C) Kidneys (D) Adipose tissue

Last Answer : B

The hydrolysis of Glucose-6-phosphate is catalysed by a specific phosphatase which is found only in (A) Liver, intestines and kidneys (B) Brain, spleen and adrenals (C) Striated muscle (D) Plasma

Description : The hydrolysis of Glucose-6-phosphate is catalysed by a specific phosphatase which is found only in (A) Liver, intestines and kidneys (B) Brain, spleen and adrenals (C) Striated muscle (D) Plasma

Last Answer : A

The tissues with the highest total glycogen content are (A) Muscle and kidneys (B) Kidneys and liver (C) Liver and muscle (D) Brain and Liver

Description : The tissues with the highest total glycogen content are (A) Muscle and kidneys (B) Kidneys and liver (C) Liver and muscle (D) Brain and Liver

Last Answer : C

Glucose-6-phosphatase is not present in (A) Liver and kidneys (B) Kidneys and muscles (C) Kidneys and adipose tissue (D) Muscles and adipose tissue

Description : Glucose-6-phosphatase is not present in (A) Liver and kidneys (B) Kidneys and muscles (C) Kidneys and adipose tissue (D) Muscles and adipose tissue

Last Answer : D

Degradations of Hb takes place in (A) Mitochondrion (B) Erythrocytes (C) Cytosol of cell (D) R.E. cells

Description : Degradations of Hb takes place in (A) Mitochondrion (B) Erythrocytes (C) Cytosol of cell (D) R.E. cells

Last Answer : Answer : D

Androgens are synthesised in (A) Leydig cells in testes (B) Sertoli cells in testes (C) Seminiferous tubules (D) Prostate gland

Description : Androgens are synthesised in (A) Leydig cells in testes (B) Sertoli cells in testes (C) Seminiferous tubules (D) Prostate gland

Last Answer : Answer : A

Epinephrine is synthesised in (A) Chromaffin cells of adrenal medulla (B) Sympathetic ganglia (C) Brain (D) All of these

Description : Epinephrine is synthesised in (A) Chromaffin cells of adrenal medulla (B) Sympathetic ganglia (C) Brain (D) All of these

Last Answer : Answer : D

Parathyroid hormone (PTH) is synthesised in (A) Chief cells of parathyroid glands (B) Oxyphil cells of parathyroid glands (C) Para follicular cells of thyroid glands (D) Follicular cells of thyroid gland

Description : Parathyroid hormone (PTH) is synthesised in (A) Chief cells of parathyroid glands (B) Oxyphil cells of parathyroid glands (C) Para follicular cells of thyroid glands (D) Follicular cells of thyroid gland

Last Answer : Answer : A

Histamine is synthesised in (A) Brain (B) Mast cells (C) Basophils (D) All of these

Description : Histamine is synthesised in (A) Brain (B) Mast cells (C) Basophils (D) All of these

Last Answer : Answer : D

The transfusion of fresh frozen plasma (FFP) is indicated for which of the following reasons? A. Volume replacement. B. As a nutritional supplement. C. Specific coagulation factor deficiency with an abnormal prothrombin time (PT) and/or an abnormal activated partial thromboplastin time (APTT). D. For the correction of abnormal PT secondary to warfarin therapy, vitamin K deficiency, or liver disease.

Description : The transfusion of fresh frozen plasma (FFP) is indicated for which of the following reasons? A. Volume replacement. B. As a nutritional supplement. C. Specific coagulation factor deficiency ... the correction of abnormal PT secondary to warfarin therapy, vitamin K deficiency, or liver disease.

Last Answer : Answer: CD DISCUSSION: The use of FFP as a volume expander is not indicated. There are currently several preparations (both crystalloid and colloid) that are equally effective and do not carry the infectious and ... vitamin K-dependent factors II, VII, IX, and X, as well as protein C and protein S

Vit. D is synthesised in presence of sunlight in (a) Skin (b) Bone(c) Liver (d) Spleen

Description : Vit. D is synthesised in presence of sunlight in (a) Skin (b) Bone(c) Liver (d) Spleen

Last Answer : (a) Skin

What are the features for Human Hepatic Sinusoidal Endothelial Cells?

Description : What are the features for Human Hepatic Sinusoidal Endothelial Cells?

Last Answer : HHSEC are isolated from human liver. HHSEC are cryopreserved immediately after purification and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HHSEC are characterized by immunofluorescent ... ). HHSEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi.

Which of the following statement(s) is/are true concerning ischemia reperfusion injury? a. During ischemia, ATP degradation results in increased plasma and intracellular levels of hypoxanthine and xanthene b. Oxygen free radicals such as the superoxide radical are involved in the expression of the proinflammatory phenotype of endothelial cells, macrophages and neutrophils c. The intracellular adhesion molecule-1 (ICAN-1) contributes to injury and disruption of the endothelial lining, with extensive capillary leak and resultant interstitial edema d. Animal models have demonstrated that passive immunization with antibodies to neutrophil adhesive complex lessen the ischemic/reperfusion microvascular injury

Description : Which of the following statement(s) is/are true concerning ischemia reperfusion injury? a. During ischemia, ATP degradation results in increased plasma and intracellular levels of ... immunization with antibodies to neutrophil adhesive complex lessen the ischemic/reperfusion microvascular injury

Last Answer : Answer: a, b, c, d During the ischemia and hypoperfusion phase, degradation of ATP stores essential to maintain cell integrity and significant loss of diffusible ... either the neutrophil adhesive complex or the endothelial selectins dramatically lessens ischemia/reperfusion microvascular injury

Which of the following statement(s) is/are correct concerning the immunoinflammatory response to shock? a. The anaphylactoxins, C3a and C5a, are products of activation of only the classical pathway of the compliment cascade b. Eicosanoids, such as prostaglandins are stored in platelets and endothelial cells and released in response to inflammatory stimuli c. Thromboxane and PGI2 have similar effects d. Platelet-activating factor can be released by both circulating and fixed tissue cells

Description : Which of the following statement(s) is/are correct concerning the immunoinflammatory response to shock? a. The anaphylactoxins, C3a and C5a, are products of activation of only the classical pathway ... effects d. Platelet-activating factor can be released by both circulating and fixed tissue cells

Last Answer : Answer: d Inflammatory mediators have recently been recognized as playing a significant role in the clinical manifestations and progression of shock and the development ... increased pulmonary vascular resistance, bronchoconstriction, peripheral vasodilatation, and increased vascular permeability

Which of the following statement(s) is/are true concerning the pulmonary response to shock? a. The acute pulmonary vascular response to shock differs markedly from that of systemic vasculature b. The pulmonary edema of ARDS occurs in the face of elevated left heart pressures c. The initial physiologic changes of ARDS involve the capillary endothelial cells and the type I pneumocyte d. Mechanisms proposed in the pathogenesis of ARDS include injury from mediators of inflammation elsewhere and from activated cellular elements e. A decrease in lung compliance may result from the loss of type I pneumocytes

Description : Which of the following statement(s) is/are true concerning the pulmonary response to shock? a. The acute pulmonary vascular response to shock differs markedly from that of systemic vasculature b. The ... elements e. A decrease in lung compliance may result from the loss of type I pneumocytes

Last Answer : Answer: c, d, e Contributing pathophysiologic processes to the pulmonary manifestations of shock include the pulmonary component of the cardiovascular response, disruption of the normal ... injury from mediators of inflammation elaborated elsewhere, and from activated cellular blood elements

Which of the following statements regarding endothelial cells in acute inflammation are true? a. Endothelial cells are characterized by phenotypic homogeneity b. Specific patterns of receptor expression regulate leukocyte adherence c. Endothelial cell nitric oxide generation regulates regional blood flow and leukocyte adhesion d. Endothelial cells may be capable of phagocytosis

Description : Which of the following statements regarding endothelial cells in acute inflammation are true? a. Endothelial cells are characterized by phenotypic homogeneity b. Specific patterns of receptor expression ... blood flow and leukocyte adhesion d. Endothelial cells may be capable of phagocytosis

Last Answer : Answer: b, c, d Endothelial cells are increasingly recognized to be phenotypically heterogeneous. Specific receptor molecules are expressed at various sites where they help to direct lymphocytes and ... rather, they possess the ability to direct and focus many aspects of an inflammatory event

Platelet activating factor is: a. Generated by the action of phospholipase A2 on membrane phospholipids b. Antiinflammatory in most of its actions c. Synthesized by endothelial and other cells d. Exerts a variety of biologic effects which are platelet-independent

Description : Platelet activating factor is: a. Generated by the action of phospholipase A2 on membrane phospholipids b. Antiinflammatory in most of its actions c. Synthesized by endothelial and other cells d. Exerts a variety of biologic effects which are platelet-independent

Last Answer : Answer: a, c, d Like the eicosanoids, platelet-activating factor (PAF) is not stored in cells but is rapidly produced during inflammation. PAF exerts a variety of biologic effects ... and LTB4. There is considerable overlap and redundancy in the effects produced by PAF and eicosanoids