Description : Long chain fatty acids penetrate the inner mitochondrial membrane (A) Freely (B) As acyl-CoA derivative (C) As carnitine derivative (D) Requiring Na dependent carrier
Last Answer : Answer : C
Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase
Last Answer : Answer : B
Description : Long chain acyl CoA penetrates mitochondria in the presence of (A) Palmitate (B) Carnitine (C) Sorbitol (D) DNP
Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity
Last Answer : Answer : A
Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase
Description : LCAT is (A) Lactose choline alamine transferse (B) Lecithin cholesterol acyl transferase (C) Lecithin carnitine acyl transferase (D) Lanoleate carbamoyl acyl transferase
Description : Long chain fatty acids are first activated to acyl CoA in the (A) Cytosol (B) Mitochodria (C) Ribosomes (D) Microsome
Description : In synthesis of Triglyceride from α-Glycero phosphate and acetyl CoA, the first intermediate formed is (A) β-diacyl glycerol (B) Acyl carnitine (C) Monoacyl glycerol(D) Phosphatidic acid
Last Answer : Answer : D
Description : The carbon chain of fatty acids is shortened by 2 carbon atoms at a time. This involves successive reactions catalysed by 4-enzymes. These act the following order: (A) Acetyl CoA dehydrogenase, ... CoA dehydrogenase (D) Enoyl hydrase, β-OH acyl CoA dehydrogenase, acyl CoA dehydrogenase, thiolose,
Description : Mitochondrial membrane is permeable to (A) Short chain fatty acids (B) Medium chain fatty acids (C) Long chain fatty acids (D) All of these
Description : Carnitine acylcarnitine translocase is present (A) In the inner mitochondrial membrane (B) In the mitochondrial matrix (C) On the outer surface of inner mitochondrial membrane (D) On the inner surface of inner mitochondrial membrane
Description : Carnitine is required for the transport of (A) Triglycerides out of liver (B) Triglycerides into mitochondria (C) Short chain fatty acids into mitochondria (D) Long chain fatty acids into mitochondria
Description : This catalyzes formation of CoA derivatives from fatty acid, CoA and ATP: (A) Acyl CoA dehydrogenase (B) Enoyl hydrase (C) β-OH acyl CoA dehydrogenase (D) Thio kinase
Description : FAD containing enzyme, catalyzing formation of α, β unsaturated fatty acyl CoA derivative. (A) Acyl CoA dehydrogenase (B) Enoyl hydrase (C) β-OH acyl CoA dehydrogenase (D) Thiolase
Description : Both Acyl carrier protein (ACP) of fatty acid synthetase and coenzyme (CoA) are (A) Contain reactive phosphorylated (B) Contain thymidine (C) Contain phosphopantetheine reactive groups (D) Contain cystine reactive groups
Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex
Description : Synthesis of polyunsaturated fatty acids involves the enzyme systems: (A) Acyl transferase and hydratase (B) Desaturase and elongase (C) Ketoacyl-CoA reductase and hydratase (D) Dihydroxyacetone phosphate
Description : Conversion of fatty acyl-CoA to an acylCoA derivative having 2 more carbon atoms involves as acetyl donar: (A) Acetyl-CoA (B) Succinyl-CoA (C) Propionyl-CoA (D) Malonyl-CoA
Description : Intermediate in the denovo synthesis of triacyl glycerols include all the following except (A) Fatty acyl CoA (B) CDP diacyl glycerol (C) Glycerol-3-phosphate (D) Lysophosphatidic acid
Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103
Description : During each cycle of β-oxidation of fatty acid, all the following compounds are generated except (A) NADH (B) H2O (C) FAD (D) Acyl CoA
Description : Fatty acids are activated to acyl CoA by the enzyme thiokinase: (A) NAD+ (B) NADP+ (C) CoA (D) FAD+
Description : The enzyme acyl-CoA synthase catalyses the conversion of a fatty acid of an active fatty acid in the presence of (A) AMP (B) ADP (C) ATP (D) GTP
Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form
Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates
Description : All the following statements about carnitine are true except (A) It can be synthesised in the human body (B) It can be synthesized from methionine and lysine (C) It is required for transport of short chain fatty acids into mitochondria (D) Its deficiency can occur due to haemodialysis
Description : Carnitine is synthesized from (A) Lysine (B) Serine (C) Choline (D) Arginine
Description : All the following processes occur rapidly in the membrane lipid bilayer except (A) Flexing of fatty acyl chains (B) Lateral diffusion of phospholipids (C) Transbilayer diffusion of phopholipids (D) Rotation of phospholipids around their long axes
Last Answer : C
Description : The electron transport chain within the inner mitochondrial membrane creates a gradient of ____________ across the inner membrane which is utilized to drive the activity of ATP synthase and the generation of ATP.
Last Answer : Hydrogen (H+ ions) or protons
Description : Mitochondrial thiokinase acts on (A) Short chain of fatty acids (B) Medium chain fatty acids (C) Long chain fatty acids (D) All of these
Description : Oxidation of fatty acids occurs (A) In the cytosol (B) In the matrix of mitochondria (C) On inner mitochondrial membrane (D) On the microsomes
Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue
Description : C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these
Description : The acetyl CoA formed on β-oxidation of all long chain fatty acids is metabolized under normal circumstances to (A) CO2 and water (B) Cholesterol (C) Fatty acids (D) Ketone bodies
Description : As a result of each oxidation a long chain fatty acid is cleaved to give (A) An acid with 3-carbon less and propionyl CoA (B) An acid with 2-carbon less and acetyl CoA (C) An acid with 2-carbon less and acetyl CoA (D) An acid with 4-carbon and butyryl CoA
Description : All long chain fatty acids with even number of carbon atoms are oxidized to a pool of _________ by β-oxidation. (A) CO2 (B) Propionic acid (C) Acetic acid (D) Acetyl CoA
Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these
Description : Long chain fatty acids are first activated to acetyl-CoA in (A) Cytosol (B) Microsomes (C) Nucleus (D) Mitochondria
Description : All the following processes occur rapidly in the membrane lipid bilayer except (A) Flexing of fatty acyl chains (B) Lateral diffusion of phospholipids (C) Transbilayer diffusion of phospholipids (D) Rotation of phospholipids around their long axes
Last Answer : (C) Transbilayer diffusion of phospholipids
Description : Which of the following component of respiratory chain is not attached to the inner mitochondrial membrane? (A) Coenzyme Q (B) Cytochrome c (C) Both (A) and (B) (D) None of these
Description : The redox carriers are grouped into respiratory chain complex (A) In the inner mitochondrial membrane (B) In mitochondiral matrix (C) On the outer mitochondrial membrane (D) On the inner surface of outer mitochondrial membrane
Description : Fatty acids can be transported into and out of cell membrane by (A) Active transport (B) Facilitated transport (C) Diffusion (D) Osmosis
Last Answer : B
Description : The chemical inhibiting oxidative phosphorylation, Adependent on the transport of adenine nucleotides across the inner mitochondrial membrane is (A) Oligomycin (B) Atractyloside (C) Dinitrophenol (D) Pentachlorophenol
Description : β-Oxidation of odd-carbon fatty acid chain produces (A) Succinyl CoA (B) Propionyl CoA (C) Acetyl CoA (D) Malonyl CoA
Description : Esters and amides are most easily made by nucleophilic acyl substitution reactions on : (a) acid anhydrides (b) carboxylates (c) carboxylic acids (d) acid chlorides
Last Answer : acid chlorides
Description : Why do aldehydes undergo nucleophilic addition reactions while esters undergo nucleophilic acyl substitution reactions? (a) The carbonyl carbon of an ester is more electrophilic than that of an aldehyde. (b) ... adds to an aldehyde, neither H− nor R− can be eliminated since they are strongly basic
Last Answer : Once the nucleophile adds to an aldehyde, neither H− nor R− can be eliminated since they are strongly basic
Description : Sphingosine is synthesized from (A) Palmitoyl CoA and Choline (B) Palmitoyl CoA and ethanolamine (C) Palmitoyl CoA and serine (D) Acetyl CoA and choline
Description : Activation of fatty acids requires all the following except (A) ATP (B) Coenzyme A (C) Thiokinase (D) Carnitine
Description : Hormonal stimulation of the formation of the second messenger inositol 1,4,5 triphosphate (IP3) quickly leads to the release of which other intracellular messenger? (A) cAMP (B) Prostaglandin (C) Calcinon (D) Leukotriene
Description : Ceramide is formed by the combination of sphingosine and (A) Acetyl-CoA (B) Acyl-CoA (C) Malonyl-CoA (D) Propionyl-CoA