Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase
Last Answer : Answer : C
Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these
Last Answer : Answer : D
Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity
Last Answer : Answer : A
Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex
Last Answer : Answer : B
Description : The carbon chain of fatty acids is shortened by 2 carbon atoms at a time. This involves successive reactions catalysed by 4-enzymes. These act the following order: (A) Acetyl CoA dehydrogenase, ... CoA dehydrogenase (D) Enoyl hydrase, β-OH acyl CoA dehydrogenase, acyl CoA dehydrogenase, thiolose,
Description : FAD containing enzyme, catalyzing formation of α, β unsaturated fatty acyl CoA derivative. (A) Acyl CoA dehydrogenase (B) Enoyl hydrase (C) β-OH acyl CoA dehydrogenase (D) Thiolase
Description : In synthesis of Triglyceride from α-Glycero phosphate and acetyl CoA, the first intermediate formed is (A) β-diacyl glycerol (B) Acyl carnitine (C) Monoacyl glycerol(D) Phosphatidic acid
Description : Long chain fatty acyl CoA esters are transported across the mitochondrial membrane by (A) cAMP (B) Prostaglandin (C) Carnitine (D) Choline
Description : Long chain fatty acids penetrate the inner mitochondrial membrane (A) Freely (B) As acyl-CoA derivative (C) As carnitine derivative (D) Requiring Na dependent carrier
Description : The initial step of the citric acid cycle is (A) Conversion of pyruvate to acetyl-CoA (B) Condensation of acetyl-CoA with oxaloacetate (C) Conversion of citrate to isocitrate (D) Formation of α -ketoglutarate catalysed by isocitrate dehydrogenase
Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates
Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate
Description : Which of the following metabolite integrates glucose and fatty acid metabolism? (A) Acetyl CoA (B) Pyruvate (C) Citrate (D) Lactate
Last Answer : A
Description : Conversion of pyruvate into acetyl CoA is catalysed by (A) Pyruvate dehydrogenase (B) Didrolipoyl acetyl transferase (C) Dihydrolipoyl dehydrogenase (D) All the 3 acting in concert
Description : Pyruvate dehydrogenase a multienzyme complex is required for the production of (A) Acetyl-CoA (B) Lactate (C) Phosphoenolpyruvate (D) Enolpyruvate
Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form
Description : For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate
Description : The formation of ∆2-trans-enoyl-CoA from acyl-CoA requires the enzyme: (A) Acyl-CoA synthetase (B) Acyl-CoA dehydrogenase (C) 3-Hydroxy acyl-CoA dehydrogenase (D) Thiolase
Description : A flavoprotein in pyruvate dehydrogenase complex is (A) Pyruvate dehydrogenase (B) Didrolipoyl acetyl transferase (C) Dihydrolipoyl dehydrogenase (D) None of these ENZYMES 161
Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate
Description : Synthesis of polyunsaturated fatty acids involves the enzyme systems: (A) Acyl transferase and hydratase (B) Desaturase and elongase (C) Ketoacyl-CoA reductase and hydratase (D) Dihydroxyacetone phosphate
Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase
Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones
Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA
Description : This catalyzes formation of CoA derivatives from fatty acid, CoA and ATP: (A) Acyl CoA dehydrogenase (B) Enoyl hydrase (C) β-OH acyl CoA dehydrogenase (D) Thio kinase
Description : Carboxylation of acetyl-CoA to malonylCoA requires the enzyme: (A) Acetyl-CoA carboxylase (B) Pyruvate carboxylase (C) Acetyl transacylase (D) Acyl CoA-synthetase
Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103
Description : A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP
Description : Thiamine is essential for (A) Pyruvate dehydrogenase (B) Isocitrate dehydrogenase (C) Succinate dehydrogenase (D) Acetyl CoA synthetase ENZYMES 165
Description : An allosteric inhibitor of pyruvate dehydrogenase is (A) Acetyl CoA (B) ATP (C) NADH (D) Pyruvate
Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase
Description : Conversion of fatty acyl-CoA to an acylCoA derivative having 2 more carbon atoms involves as acetyl donar: (A) Acetyl-CoA (B) Succinyl-CoA (C) Propionyl-CoA (D) Malonyl-CoA
Description : Jamaican vomiting sickness is due to inactivation of the enzyme (A) Pyruvate carboxylase (B) Acyl-Co-A synthetase (C) Acyl-Co-A dehydrogense (D) Thiolase
Description : The protein, which is in fact a multifunctional enzyme complex in higher organism is (A) Acetyl transacylase (B) Malonyl transacylase (C) 3-Hydroxy acyl-ACP dehyratase (D) Fatty acid synthase
Description : Zellweger’s syndrome is due to inherited absence of (A) Peroxisomes (B) Phospholipase A1 (C) Acyl-Co-A dehydrogenase (D) Thiolase
Description : LCAT is (A) Lactose choline alamine transferse (B) Lecithin cholesterol acyl transferase (C) Lecithin carnitine acyl transferase (D) Lanoleate carbamoyl acyl transferase
Description : Intermediate in the denovo synthesis of triacyl glycerols include all the following except (A) Fatty acyl CoA (B) CDP diacyl glycerol (C) Glycerol-3-phosphate (D) Lysophosphatidic acid
Description : Mitochondrial α-ketoglutarate dehydrogenase complex requires all the following to function except (A) CoA (B) FAD (C) NAD+ (D) NADP+
Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these
Description : Acetyl-CoA can be formed from (A) Pyruvate (B) Fatty acids (C) ketone bodies (D) All of these
Description : Fatty acids can not be converted into carbohydrates in the body, as the following reaction is not possible: (A) Conversion of glucose-6-phosphate into glucose (B) Fructose 1, 6 diphosphate to ... phosphate (C) Transformation of acetyl CoA to pyruvate (D) Formation of acetyl CoA from fatty acids
Description : Fatty acids cannot be converted into carbohydrates in the body as the following reaction is not possible. (A) Conversion of glucose-6-phosphate into glucose (B) Fructose 1,6-bisphosphate to fructose- ... (C) Transformation of acetyl CoA to pyruvate (D) Formation of acetyl CoA from fatty acids
Last Answer : C
Description : Long chain acyl CoA penetrates mitochondria in the presence of (A) Palmitate (B) Carnitine (C) Sorbitol (D) DNP
Description : The most important mechanism by which gram negative bacilli acquire chloramphenicol resistance is (a) Decreased permeability into the bacterial cell (b) Acquisition of a plasmid encoded ... bacterial ribosome for chloramphenicol (d) Switching over from ribosomal to mitochondrial protein synthesis
Last Answer : Ans: B
Description : Pyruvate dehydrogenase is a/an (A) Isomerase (B) Lyase (C) Ligase (D) Oxido reductase
Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP
Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these
Description : Acetyl CoA is not used for the synthesis of (A) Fatty acid (B) Cholesterol (C) Pyruvic acid (D) Citric acid
Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?
Last Answer : ATP citrate lyase.
Description : In β-oxidation 3-ketoacyl-CoA is splitted at the 2, 3 position by the enzyme: (A) Hydratase (B) Dehydrogenase (C) Reducatse (D) Thiolase