Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin

1 Answer

Answer :

Answer : B

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Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP

Last Answer : A

Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate

Last Answer : Answer : A

Description : Biotin is a coenzyme for (A) Pyruvate carboxylase (B) Acetyl CoA carboxylase (C) Propionyl CoA carboxylase (D) All of these

Last Answer : Answer : D

Description : Cocarboxylase is (A) Thiamine pyrophosphate (B) Pyridoxal phosphate (C) Biotin (D) CoA

Last Answer : Answer : C

Description : The conversion of pyruvate to acetyl CoA and CO2 (A) Is reversible (B) Involves the participation of lipoic acid (C) Depends on the coenzyme biotin (D) Occurs in the cytosol

Last Answer : B

Description : A carrier molecule in the citric acid cycle is (A) Acetyl-CoA (B) Citrate (C) Oxaloacetate (D) Malate

Last Answer : Answer : C

Description : Mitochondrial lipogenesis requires (A) bicarbonate (B) biotin (C) acetyl CoA carboxylase (D) NADPH

Last Answer : Answer : D

Description : The initial step of the citric acid cycle is (A) Conversion of pyruvate to acetyl-CoA (B) Condensation of acetyl-CoA with oxaloacetate (C) Conversion of citrate to isocitrate (D) Formation of α -ketoglutarate catalysed by isocitrate dehydrogenase

Last Answer : Answer : B

Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Last Answer : Answer : A

Description : In presence of the following cofactor, pyruvate carboxylase converts pyruvate to oxaloacetate: (A) ATP, Protein and CO2 (B) CO2 and ATP (C) CO2 (D) Protein

Last Answer : A

Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase

Last Answer : Answer : A

Description : Carboxylation of acetyl-CoA to malonylCoA requires the enzyme: (A) Acetyl-CoA carboxylase (B) Pyruvate carboxylase (C) Acetyl transacylase (D) Acyl CoA-synthetase

Last Answer : Answer : A

Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

Last Answer : Answer : D

Description : Acetyl CoA carboxylase is activated by (A) Citrate (B) Insulin (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Description : The coenzyme not involved in the formation of acetyl-CoA from pyruvate is (A) TPP (B) Biotin (C) NAD (D) FAD

Last Answer : Answer : B

Description : Thiamine is essential for (A) Pyruvate dehydrogenase (B) Isocitrate dehydrogenase (C) Succinate dehydrogenase (D) Acetyl CoA synthetase ENZYMES 165

Last Answer : Answer : B

Description : Connecting link between glycolysis and Krebs’ cycle before pyruvate entering Krebs’ cycle is changed to (a) oxaloacetate (b) PEP (c) pyruvate (d) acetyl CoA.

Last Answer : (d) acetyl CoA.

Description : Of Which warburg’s yellow enzyme contains as a prosthetic group? (A) Thiamine pyrophosphate (B) Biotin (C) NAD+ (D) Riboflavin-5-phosphate

Last Answer : Answer : D

Description : Mitochondrial membrane is freely preamble to (A) Pyruvate (B) Malate (C) Oxaloacetate (D) Fumarate

Last Answer : Answer : B

Description : The example of generation of a high energy phosphate at the substrate level in the citric acid cycle is the reaction: (A) Isocitrate α-Ketoglutarate (B) Succinate α-fumarate (C) Malate α-oxaloacetate (D) Succinyl CoA α-Succinate

Last Answer : Answer : D

Description : Carboxylation of acetyl—CoA to malonyl — CoA takes place in presence of (A) FAD+ (B) Biotin (C) NAD+ (D) NADP+

Last Answer : Answer : C

Description : Pyruvate carboxylase reaction (pyruvate to oxaloacetate) needs which co-enzyme?

Last Answer : Biotin and ATP.

Description : The coenzyme required for conversion of pyruvate to oxaloacetate is (A) FAD (B) NAD (C) TPP (D) Biotin

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Description : Biotin is a coenzyme for (A) Pyruvate dehydrogenase (B) Pyruvate carboxylase (C) PEP carboxykinase (D) Glutamate pyruvate transminase

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Description : For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate

Last Answer : Answer : A

Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

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Description : Insulin decreases the activity of (A) cAMP dependent protein kinase (B) HMG CoA-reductas (C) Phosphodiesterase (D) Acetyl CoA-carboxylase

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Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

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Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex

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Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step

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Description : Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase

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Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase

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Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these

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Description : Fat soluble vitamins are – (1) Tocopherol, Niacin, Cyanocobalamin (2) Calciferol, Carotene, Tocopherol (3) Ascorbic acid, Calciferol, Riboflavin (4) Thiamine, Carotene, Biotin

Last Answer : (2) Calciferol, Carotene, Tocopherol Explanation: Calciferol (Vitamin D): Tocopherols and tocotrienols (Vitamin E); Phylloquinone, menaquinones (Vitamin K); and Retinol, retinal, and four carotenoids including beta carotene (Vitamin Al are all fat soluble vitamins.

Description : Defeciency of following vitamin decreases hemoglobin production ? A. Biotin B. Thiamine C. Niacin D. Pyridoxine (Answer) E. None of these

Last Answer : D. Pyridoxine (Answer)

Description : Fat soluble vitamins are (1) Tocopherol, Niacin, Cyanocobalamin (2) Calciferol, Carotene, Tocopherol (3) Ascorbic acid, Calciferol, Riboflavin (4) Thiamine, Carotene, Biotin

Last Answer : Calciferol, Carotene, Tocopherol

Description : Pyruvate dehydrogenase contains all except (A) Biotin (B) NAD (C) FAD (D) CoA

Last Answer : Answer : A

Description : Which one of the following cofactors must be utilized during the conversion of acetyl CoA to malonyl CoA? (A) TPP (B) ACP (C) NAD+ (D) Biotin

Last Answer : Answer : D

Description : A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP

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Description : Biotin is required for the reaction of CO2 with (A) Water (B) Acetyl CoA (C) NH3 (D) Incorporation of carbon 6 in purine

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Description : The cofactor or its derivative required for the conversion of acetyl CoA to malonylCoA is (A) FAD (B) ACP (C) NAD+ (D) Biotin

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Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP

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Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

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Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

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Description : End product of aerobic glycolysis is (A) Acetyl CoA (B) Lactate (C) Pyruvate (D) CO2 and H2O

Last Answer : Answer : C

Description : An allosteric inhibitor of pyruvate dehydrogenase is (A) Acetyl CoA (B) ATP (C) NADH (D) Pyruvate

Last Answer : Answer : A

Description : Conversion of pyruvate into acetyl CoA is catalysed by (A) Pyruvate dehydrogenase (B) Didrolipoyl acetyl transferase (C) Dihydrolipoyl dehydrogenase (D) All the 3 acting in concert

Last Answer : Answer : D

Description : Pyruvate is converted into acetyl-CoA by (A) Decarboxylation (B) Dehydrogenation (C) Oxidative decarboxylation (D) Oxidative deamination

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Description : Acetyl-CoA can be formed from (A) Pyruvate (B) Fatty acids (C) ketone bodies (D) All of these

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Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Last Answer : Answer : C