In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate

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Answer :

Answer :  A

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Description : The initial step of the citric acid cycle is (A) Conversion of pyruvate to acetyl-CoA (B) Condensation of acetyl-CoA with oxaloacetate (C) Conversion of citrate to isocitrate (D) Formation of α -ketoglutarate catalysed by isocitrate dehydrogenase

Last Answer : Answer : B

Description : For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate

Last Answer : Answer : A

Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP

Last Answer : A

Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Last Answer : Answer : A

Description : Thiamine is essential for (A) Pyruvate dehydrogenase (B) Isocitrate dehydrogenase (C) Succinate dehydrogenase (D) Acetyl CoA synthetase ENZYMES 165

Last Answer : Answer : B

Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin

Last Answer : Answer : B

Description : The reaction of Kreb’s cycle which does not require cofactor of vitamin B group is (A) Citrate isocitrate (B) α -Ketoglutarate succinate (C) Malate oxaloacetate (D) Succinate fumarate

Last Answer : Answer : A

Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase

Last Answer : Answer : B

Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these

Last Answer : Answer : D

Description : The example of generation of a high energy phosphate at the substrate level in the citric acid cycle is the reaction: (A) Isocitrate α-Ketoglutarate (B) Succinate α-fumarate (C) Malate α-oxaloacetate (D) Succinyl CoA α-Succinate

Last Answer : Answer : D

Description : An aneplerotic reaction which sustains the availability of oxaloacetate is the carboxylation of (A) Glutamate (B) Pyruvate (C) Citrate (D) Succinate

Last Answer : B

Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

Last Answer : Answer : D

Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase

Last Answer : Answer : B

Description : Carboxylation of acetyl-CoA to malonylCoA requires the enzyme: (A) Acetyl-CoA carboxylase (B) Pyruvate carboxylase (C) Acetyl transacylase (D) Acyl CoA-synthetase

Last Answer : Answer : A

Description : A carrier molecule in the citric acid cycle is (A) Acetyl-CoA (B) Citrate (C) Oxaloacetate (D) Malate

Last Answer : Answer : C

Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex

Last Answer : Answer : B

Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

Last Answer : Answer : D

Description : Acetyl CoA carboxylase is activated by (A) Citrate (B) Insulin (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Description : Pyruvate carboxylase reaction (pyruvate to oxaloacetate) needs which co-enzyme?

Last Answer : Biotin and ATP.

Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Last Answer : Answer : B

Description : Mitochondrial lipogenesis requires (A) bicarbonate (B) biotin (C) acetyl CoA carboxylase (D) NADPH

Last Answer : Answer : D

Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase

Last Answer : Answer : A

Description : Biotin is a coenzyme for (A) Pyruvate carboxylase (B) Acetyl CoA carboxylase (C) Propionyl CoA carboxylase (D) All of these

Last Answer : Answer : D

Description : An allosteric inhibitor of pyruvate dehydrogenase is (A) Acetyl CoA (B) ATP (C) NADH (D) Pyruvate

Last Answer : Answer : A

Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Last Answer : Answer : C

Description : Which of the following metabolite integrates glucose and fatty acid metabolism? (A) Acetyl CoA (B) Pyruvate (C) Citrate (D) Lactate

Last Answer : A

Description : Conversion of pyruvate into acetyl CoA is catalysed by (A) Pyruvate dehydrogenase (B) Didrolipoyl acetyl transferase (C) Dihydrolipoyl dehydrogenase (D) All the 3 acting in concert

Last Answer : Answer : D

Description : The metabolism of protein is integrated with that of carbohydrate and fat through (A) Oxaloacetate (B) Citrate (C) Isocitrate (D) Malate

Last Answer : Answer : A

Description : Connecting link between glycolysis and Krebs’ cycle before pyruvate entering Krebs’ cycle is changed to (a) oxaloacetate (b) PEP (c) pyruvate (d) acetyl CoA.

Last Answer : (d) acetyl CoA.

Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

Last Answer : Answer : D

Description : Fluoroacetate inhibits the reaction of citric acid cycle: (A) Isocitrate α-Ketoglutarate (B) Fumarate α-Malate (C) Citrate α-cis-aconitate (D) Succinate α-fumarate

Last Answer : Answer : C

Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

Last Answer : Answer : A

Description : All of the following are allosteric enzymes except (A) Citrate synthetase (B) a-Ketoglutarate dehdrogenase (C) Succinate thiokinase (D) Succinate dehydrogenase

Last Answer : Answer : C

Description : Calcium is required for the activation of the enzyme: (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase

Last Answer : Answer : D

Description : In presence of the following cofactor, pyruvate carboxylase converts pyruvate to oxaloacetate: (A) ATP, Protein and CO2 (B) CO2 and ATP (C) CO2 (D) Protein

Last Answer : A

Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

Last Answer : Answer : A

Description : In urea synthesis, the amino acid functioning solely as an enzyme activator: (A) N-acetyl glutamate(B) Ornithine (C) Citrulline (D) Arginine

Last Answer : Answer : A

Description : Pyruvate is converted to acetyl CoA by which enzyme?

Last Answer : Pyruvate dehydrogenate.

Description : Pyruvate carboxylase is regulated by (A) Induction (B) Repression (C) Allosteric regulation(D) All of these

Last Answer : D

Description : Pyruvate dehydrogenase a multienzyme complex is required for the production of (A) Acetyl-CoA (B) Lactate (C) Phosphoenolpyruvate (D) Enolpyruvate

Last Answer : Answer : A

Description : An allosteric enzyme responsible for controlling the rate of T.C.A cycle is (A) Malate dehydrogenase (B) Isocitrate dehydrogenase (C) Fumarase (D) Aconitase

Last Answer : B

Description : Anion gap of plasma can be due to the presence of all the following except (A) Bicarbonate (B) Lactate (C) Pyruvate (D) Citrate

Last Answer : Answer : A

Description : An enzyme of the citric acid cycle also found outside the mitochondria is (A) Isocitrate dehydrogenase (B) Citrate synthetase (C) α-Ketoglutarate dehydrogenase (D) Malate dehydrogenase

Last Answer : Answer : C

Description : Cytosolic and mitochondrial carbamoyl phosphate synthetase have the following similarity: (A) Both use ammonia as a substance (B) Both provide carbamoyl phosphate for urea synthesis (C) Both require N-acetylglutamate as an activator (D) Both are allosteric enzymes

Last Answer : Answer : C

Description : The following is an enzyme required for glycolysis: (A) Pyruvate kinase (B) Pyruvate carboxylase (C) Glucose-6-phosphatose (D) Glycerokinase

Last Answer : A

Description : The following is an enzyme required for glycolysis: (A) Pyruvate kinase (B) Pyruvate carboxylase (C) Glucose-6-phosphatase (D) Glycerokinase

Last Answer : A

Description : Insulin decreases the activity of (A) cAMP dependent protein kinase (B) HMG CoA-reductas (C) Phosphodiesterase (D) Acetyl CoA-carboxylase

Last Answer : Answer : A

Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step

Last Answer : Answer : A

Description : Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase

Last Answer : Answer : D

Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?

Last Answer : ATP citrate lyase.