The enzyme deficient in Sandhoff’s disease is (A) α-Fucosidase (B) Hexosaminidase A and B (C) β-Galactosidase (D) β-Glucosidase

The enzyme deficient in Sandhoff’s disease is (A) α-Fucosidase (B) Hexosaminidase A and B (C) β-Galactosidase (D) β-Glucosidase
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The enzyme deficient in Krabbe’s disease is (A) Hexosaminidase A(B) Arylsuphatase A (C) β-Galactosidase (D) α-Fucosidase

Description : The enzyme deficient in Krabbe’s disease is (A) Hexosaminidase A(B) Arylsuphatase A (C) β-Galactosidase (D) α-Fucosidase

Last Answer : Answer : C

Gaucher’s disease is due to the deficiency of the enzyme: (A) α-Fucosidase (B) β-Galactosidase (C) β-Glucosidase (D) Sphingomyelinase

Description : Gaucher’s disease is due to the deficiency of the enzyme: (A) α-Fucosidase (B) β-Galactosidase (C) β-Glucosidase (D) Sphingomyelinase

Last Answer : Answer : C

The enzyme deficient in Fabry’s disease is (A) α-Galactosidase (B) β-Galactosidase (C) α-Glucosidase (D) β-Glucosidase

Description : The enzyme deficient in Fabry’s disease is (A) α-Galactosidase (B) β-Galactosidase (C) α-Glucosidase (D) β-Glucosidase

Last Answer : Answer : A

α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease

Description : α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease

Last Answer : Answer : D

Metachromatic leukodystrophy is due to deficiency of enzyme: (A) α-Fucosidase (B) Arylsulphatase A (C) Ceramidase (D) Hexosaminidase A

Description : Metachromatic leukodystrophy is due to deficiency of enzyme: (A) α-Fucosidase (B) Arylsulphatase A (C) Ceramidase (D) Hexosaminidase A

Last Answer : Answer : B

Wolman’s disease is due to deficiency of (A) Cholesteryl ester hydrolase (B) Hexosaminidase A (C) α-Fucosidase (D) Arylsulphatase A

Description : Wolman’s disease is due to deficiency of (A) Cholesteryl ester hydrolase (B) Hexosaminidase A (C) α-Fucosidase (D) Arylsulphatase A

Last Answer : Answer : A

Farber’s disease is due to the deficiency of the enzyme: (A) α-Galactosidase (B) Ceramidase (C) β-Glucocerebrosidase (D) Arylsulphatase A.

Description : Farber’s disease is due to the deficiency of the enzyme: (A) α-Galactosidase (B) Ceramidase (C) β-Glucocerebrosidase (D) Arylsulphatase A.

Last Answer : Answer : B

The enzyme ceramidase is deficient in (A) Farber’s disease (B) Fabry’s disease (C) Sandhoff’s disease(D) Refsum’s disease

Description : The enzyme ceramidase is deficient in (A) Farber’s disease (B) Fabry’s disease (C) Sandhoff’s disease(D) Refsum’s disease

Last Answer : Answer : A

β -Galactosidase is deficient in (A) Fabry’s disease (B) Krabbe’s disease (C) Gaucher’s disease (D) Metachromatic leukodystrophy

Description : β -Galactosidase is deficient in (A) Fabry’s disease (B) Krabbe’s disease (C) Gaucher’s disease (D) Metachromatic leukodystrophy

Last Answer : Answer : B

Gaucher's Disease is associated with the deficiency of : 1) Hexosaminidase A 2) Sphingomyelinase 3) Arylsulphatase-A 4) B- Glucosidase 5) Iduronidase

Description : Gaucher's Disease is associated with the deficiency of : 1) Hexosaminidase A 2) Sphingomyelinase 3) Arylsulphatase-A 4) B- Glucosidase 5) Iduronidase

Last Answer : Answers-4 Hexosaminidase A deficiency is associated Tay-Sachs disease. Sphingomyelinase deficiency is associated with Niemann-Pick disease. Arylsulphatase-A deficiency is associated with metachromic leucodystrophy.Iduronidase deficiency is associated with Hurlers syndrome.

Krabbe’s disease is due to the deficiency of the enzyme: (A) Ceramide lactosidase (B) Ceramidase (C) β-Galactosidase (D) GM1 β-Galactosidase

Description : Krabbe’s disease is due to the deficiency of the enzyme: (A) Ceramide lactosidase (B) Ceramidase (C) β-Galactosidase (D) GM1 β-Galactosidase

Last Answer : Answer : C

Gaucher’s disease is due to deficiency of the enzyme: (A) Sphingomyelinase (B) Glucocerebrosidase (C) Galactocerbrosidase (D) β-Galactosidase

Description : Gaucher’s disease is due to deficiency of the enzyme: (A) Sphingomyelinase (B) Glucocerebrosidase (C) Galactocerbrosidase (D) β-Galactosidase

Last Answer : Answer : B

The enzyme deficient in metachromatic leukodystrophy is (A) Arylsulphatase A (B) Hexosaminidase A (C) Ceramidase (D) Sphingomyelinase

Description : The enzyme deficient in metachromatic leukodystrophy is (A) Arylsulphatase A (B) Hexosaminidase A (C) Ceramidase (D) Sphingomyelinase

Last Answer : Answer : A

Hexosaminidase A is deficient in (A) Tay-Sachs disease (B) Gaucher’s disease (C) Niemann-Pick disease (D) Fabry’s disease

Description : Hexosaminidase A is deficient in (A) Tay-Sachs disease (B) Gaucher’s disease (C) Niemann-Pick disease (D) Fabry’s disease

Last Answer : Answer : A

In glycogenolysis, the enzyme which transfers a trisaccharide unit from one branch to the other exposing 1→ 6 branch point is (A) Phosphorylase (B) α-[1→ 4]→ α-[1→ 4]→ Glucan transferase (C) Amylo [1→ 6] glucosidase (D) Amylo[1→ 4]→ [1→ 6] transglucosidase

Description : In glycogenolysis, the enzyme which transfers a trisaccharide unit from one branch to the other exposing 1→ 6 branch point is (A) Phosphorylase (B) α-[1→ 4]→ α-[1→ 4]→ Glucan transferase (C) Amylo [1→ 6] glucosidase (D) Amylo[1→ 4]→ [1→ 6] transglucosidase

Last Answer : Answer : B

In glycogenesis a branch point in the molecule is established by the enzyme (A) Amylo[1→ 4][1→ 6] transglucosidase (B) α [1→ 4] α [1→ 4] Glucan transferase (C) Amylo [1→ 6] glucosidase (D) Glycogen synthase

Description : In glycogenesis a branch point in the molecule is established by the enzyme (A) Amylo[1→ 4][1→ 6] transglucosidase (B) α [1→ 4] α [1→ 4] Glucan transferase (C) Amylo [1→ 6] glucosidase (D) Glycogen synthase

Last Answer : Answer : A

Von Gierke’s disease is characterized by the deficiency of (A) Glucose-6-phosphatase (B) α -1→ 4 Glucosidase (C) 1→ 6 Glucosidase (D) Liver phosphorylase

Description : Von Gierke’s disease is characterized by the deficiency of (A) Glucose-6-phosphatase (B) α -1→ 4 Glucosidase (C) 1→ 6 Glucosidase (D) Liver phosphorylase

Last Answer : Answer : A

A person’s lysosomes lack the enzyme β-glucosidase ?

Description : There is an inherited disease in which a person’s lysosomes lack the enzyme β-glucosidase What are the clinical and biochemical consequences of this deficiency?

Last Answer : The disease is called Gaucher disease, and it is the most common of the sphingolipidoses; its incidence in the general population is ∼1:2500. This class of disease results from defective hydrolysis of ... may show signs of mental deterioration if much of the lipid accumulates in the brain as well. 

Which enzyme will be produced in a cell if there is a nonsense mutation in the lac Y gene? (a) Transacetylase (b) Lactose permease and transacetylase (c) β-galactosidase (d) Lactose permease

Description : Which enzyme will be produced in a cell if there is a nonsense mutation in the lac Y gene? (a) Transacetylase (b) Lactose permease and transacetylase (c) β-galactosidase (d) Lactose permease

Last Answer : β-galactosidase

Neimann-Pick disease is due to the deficiency of the enzyme: (A) Hexosaminidase A and B (B) Ceramidase (C) Ceramide lactosidase (D) Sphingomyelinase CHAPTER 6 CHAPTER 6 ENZYMES

Description : Neimann-Pick disease is due to the deficiency of the enzyme: (A) Hexosaminidase A and B (B) Ceramidase (C) Ceramide lactosidase (D) Sphingomyelinase CHAPTER 6 CHAPTER 6 ENZYMES

Last Answer : Answer : D

Pompe ’s d isease is caused due to deficiency of (A) Lysosomal α-1→4 and 1→6-glucosidase (B) Glucose-6-phosphatase (C) Glycogen synthase (D) Phosphofructokinase

Description : Pompe ’s d isease is caused due to deficiency of (A) Lysosomal α-1→4 and 1→6-glucosidase (B) Glucose-6-phosphatase (C) Glycogen synthase (D) Phosphofructokinase

Last Answer : Answer : A

FAD containing enzyme, catalyzing formation of α, β unsaturated fatty acyl CoA derivative. (A) Acyl CoA dehydrogenase (B) Enoyl hydrase (C) β-OH acyl CoA dehydrogenase (D) Thiolase

Description : FAD containing enzyme, catalyzing formation of α, β unsaturated fatty acyl CoA derivative. (A) Acyl CoA dehydrogenase (B) Enoyl hydrase (C) β-OH acyl CoA dehydrogenase (D) Thiolase

Last Answer : Answer : A

Amylo 1, 6 glucosidase is called (A) Branching enzyme (B) debranching enzyme (C) Glucantransferase (D) Phosphorylase

Description : Amylo 1, 6 glucosidase is called (A) Branching enzyme (B) debranching enzyme (C) Glucantransferase (D) Phosphorylase

Last Answer : B

he following antidiabetic drug inhibits intestinal brush border α-glucosidase enzymes: A. Acarbose B. Pioglitazone C. Metformin D. Guargum

Description : he following antidiabetic drug inhibits intestinal brush border α-glucosidase enzymes: A. Acarbose B. Pioglitazone C. Metformin D. Guargum

Last Answer : A. Acarbose

.Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition because excess of β-galactosidase can switch off transcription (c) positive and inducible because it can be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Description : .Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition ... be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Last Answer : (d) negative and inducible because repressor protein prevents transcription.

Lac operon’ in E. coli, is induced by (a) ‘I’ gene (b) promoter gene (c) β-galactosidase (d) lactose.

Description : Lac operon’ in E. coli, is induced by (a) ‘I’ gene (b) promoter gene (c) β-galactosidase (d) lactose.

Last Answer : (c) β-galactosidase

Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition because excess of β-galactosidase can switch off transcription (c) positive and inducible because it can be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Description : Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition ... be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Last Answer : (d) negative and inducible because repressor protein prevents transcription.

Isoxsuprine increases limb blood flow in normal individuals, but is of limited efficacy in Buerger’s disease, because in this disease: A. Vasodilator β adrenoceptors are deficient B. There is loss of sympathetic innervation C. Blood flow to the affected limb is reduced by organic obstruction D. The drug is not delivered to the affected site

Description : Isoxsuprine increases limb blood flow in normal individuals, but is of limited efficacy in Buerger's disease, because in this disease: A. Vasodilator β adrenoceptors are deficient B. There is loss ... affected limb is reduced by organic obstruction D. The drug is not delivered to the affected site

Last Answer : C. Blood flow to the affected limb is reduced by organic obstruction

Isoxsuprine increases limb blood flow in normal individuals, but is of limited efficacy in Buerger’s disease, because in this disease: A. Vasodilator β adrenoceptors are deficient B. There is loss of sympathetic innervation C. Blood flow to the affected limb is reduced by organic obstruction D. The drug is not delivered to the affected site

Description : Isoxsuprine increases limb blood flow in normal individuals, but is of limited efficacy in Buerger's disease, because in this disease: A. Vasodilator β adrenoceptors are deficient B. There is loss ... affected limb is reduced by organic obstruction D. The drug is not delivered to the affected site

Last Answer : C. Blood flow to the affected limb is reduced by organic obstruction

Niemann-Pick disease results from deficiency of (A) Ceramidase (B) Sphingomyelinase (C) Arylsulphatase A (D) Hexosaminidase A

Description : Niemann-Pick disease results from deficiency of (A) Ceramidase (B) Sphingomyelinase (C) Arylsulphatase A (D) Hexosaminidase A

Last Answer : Answer : B

Tay-Sachs disease results from inherited deficiency of (A) Arylsulphatase A (B) Hexosaminidase A (C) Sphingomyelinase (D) Ceramidase

Description : Tay-Sachs disease results from inherited deficiency of (A) Arylsulphatase A (B) Hexosaminidase A (C) Sphingomyelinase (D) Ceramidase

Last Answer : Answer : B

Sildenafil is contraindicated in patients taking the following class of drugs: A. α-adrenergic blockers B. β-adrenergic blockers C. Organic nitrates D. Angiotensin converting enzyme inhibitors

Description : Sildenafil is contraindicated in patients taking the following class of drugs: A. α-adrenergic blockers B. β-adrenergic blockers C. Organic nitrates D. Angiotensin converting enzyme inhibitors

Last Answer : C. Organic nitrates

Sildenafil is contraindicated in patients taking the following class of drugs: A. α-adrenergic blockers B. β-adrenergic blockers C. Organic nitrates D. Angiotensin converting enzyme inhibitors

Description : Sildenafil is contraindicated in patients taking the following class of drugs: A. α-adrenergic blockers B. β-adrenergic blockers C. Organic nitrates D. Angiotensin converting enzyme inhibitors

Last Answer : C. Organic nitrates

Refsum’s disease is due to deficiency of the enzyme: (A) Pytantate-α-oxidase (B) Glucocerebrosidase (C) Galactocerebrosidase (D) Ceramide trihexosidase

Description : Refsum’s disease is due to deficiency of the enzyme: (A) Pytantate-α-oxidase (B) Glucocerebrosidase (C) Galactocerebrosidase (D) Ceramide trihexosidase

Last Answer : Answer : A

An inborn error, maple syrup urine disease is due to deficiency of the enzyme: (A) Isovaleryl-CoAhydrogenase (B) Phenylalnine hydroxylase (C) Adenosyl transferase (D) α-Ketoacid decarboxylase

Description : An inborn error, maple syrup urine disease is due to deficiency of the enzyme: (A) Isovaleryl-CoAhydrogenase (B) Phenylalnine hydroxylase (C) Adenosyl transferase (D) α-Ketoacid decarboxylase

Last Answer : Answer : D

The colonies of recombinant bacteria appear white in contrast to blue colonies of non-recombinant bacteria because of (a) insertional inactivation of alpha galactosidase in recombinant bacteria (b) inactivation of glycosidase enzyme in recombinant bacteria (c) non-recombinant bacteria containing beta galactosidase (d) insertional inactivation of alpha galactosidase in non-recombinant bacteria.

Description : The colonies of recombinant bacteria appear white in contrast to blue colonies of non-recombinant bacteria because of (a) insertional inactivation of alpha galactosidase in recombinant ... beta galactosidase (d) insertional inactivation of alpha galactosidase in non-recombinant bacteria.

Last Answer : (c) non-recombinant bacteria containing beta galactosidase

Synthesis of RNA molecule is terminated by a signal which is recognised by (A) α-factor (B) β-factor (C) δ-factor (D) ρ

Description : Synthesis of RNA molecule is terminated by a signal which is recognised by (A) α-factor (B) β-factor (C) δ-factor (D) ρ

Last Answer : Answer : D

Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate

Description : Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate

Last Answer : Answer : D

The mammalian DNA polymerase involved in error correction is (A) DNA polymerase α (B) DNA polymerase β (C) DNA polymerase γ (D) DNA polymerase δ

Description : The mammalian DNA polymerase involved in error correction is (A) DNA polymerase α (B) DNA polymerase β (C) DNA polymerase γ (D) DNA polymerase δ

Last Answer : Answer : B

Primase activity is present in (A) DNA polymerase II (B) DNA polymerase α (C) DNA polymerase β (D) DNA polymerase δ

Description : Primase activity is present in (A) DNA polymerase II (B) DNA polymerase α (C) DNA polymerase β (D) DNA polymerase δ

Last Answer : Answer : B

Replication of nuclear DNA in mammals is catalysed by (A) DNA polymerase α (B) DNA polymerase β (C) DNA polymerase γ (D) DNA polymerase III

Description : Replication of nuclear DNA in mammals is catalysed by (A) DNA polymerase α (B) DNA polymerase β (C) DNA polymerase γ (D) DNA polymerase III

Last Answer : Answer : A

The key substance in the synthesis of purine, phosphoribosyl pyrophosphate is formed by (A) α-D-ribose 5-phosphate (B) 5-phospho β-D-ribosylamine (C) D-ribose (D) Deoxyribose

Description : The key substance in the synthesis of purine, phosphoribosyl pyrophosphate is formed by (A) α-D-ribose 5-phosphate (B) 5-phospho β-D-ribosylamine (C) D-ribose (D) Deoxyribose

Last Answer : Answer : A

The immediate parent of α, β and γ endorphins is (A) Pro-opiomelanocortin (B) β-lipotropin (C) ATCH (D) Lipoprotein

Description : The immediate parent of α, β and γ endorphins is (A) Pro-opiomelanocortin (B) β-lipotropin (C) ATCH (D) Lipoprotein

Last Answer : Answer : B

Corticotropin releasing hormone controls the direct release of (A) Pro-opiomelanocortin (B) α MSH (C) β MSH (D) Endorphins

Description : Corticotropin releasing hormone controls the direct release of (A) Pro-opiomelanocortin (B) α MSH (C) β MSH (D) Endorphins

Last Answer : Answer : A

Alloxan can experimentally induce diabetes mellitus due to (A) Stimulation of α cells of the islets of langerhans (B) Necrosis of the β cells of the islets (C) Potentiation of insulinase activity (D) Epinephrine like action

Description : Alloxan can experimentally induce diabetes mellitus due to (A) Stimulation of α cells of the islets of langerhans (B) Necrosis of the β cells of the islets (C) Potentiation of insulinase activity (D) Epinephrine like action

Last Answer : Answer : B

Norepinephrine binds mainly to (A) α-Adrenergic receptors (B) β-Adrenergic receptrors (C) Muscarinic receptors (D) Nicotinic receptors

Description : Norepinephrine binds mainly to (A) α-Adrenergic receptors (B) β-Adrenergic receptrors (C) Muscarinic receptors (D) Nicotinic receptors

Last Answer : Answer : A

Insulin receptor is made up of (A) One α-and one β-subunit (B) Two α-and two β-subunit (C) Two, α two β-and two γ-subunit (D) One α, one β-one γ-and one δ-subunit

Description : Insulin receptor is made up of (A) One α-and one β-subunit (B) Two α-and two β-subunit (C) Two, α two β-and two γ-subunit (D) One α, one β-one γ-and one δ-subunit

Last Answer : Answer : B

In the insulin receptor, tyrosine kinase domain is present in (A) α-Subunits (B) β-Subunits (C) γ-Subunits (D) δ-Subunits

Description : In the insulin receptor, tyrosine kinase domain is present in (A) α-Subunits (B) β-Subunits (C) γ-Subunits (D) δ-Subunits

Last Answer : Answer : B

Insulin binding sites are present on the (A) α-subunits of insulin receptor (B) β-subunits of insulin receptor (C) γ-subunits of insulin receptor (D) α-and β−subunits of insulin receptor

Description : Insulin binding sites are present on the (A) α-subunits of insulin receptor (B) β-subunits of insulin receptor (C) γ-subunits of insulin receptor (D) α-and β−subunits of insulin receptor

Last Answer : Answer : A

All the following statements about TSH are true except (A) It is a glycoprotein (B) It is made up of α- and β-subunits (C) Receptor recognition involves both the subunits (D) Its subunit is identical with those of FSH and LH

Description : All the following statements about TSH are true except (A) It is a glycoprotein (B) It is made up of α- and β-subunits (C) Receptor recognition involves both the subunits (D) Its subunit is identical with those of FSH and LH

Last Answer : Answer : D