Description : Identify one of the canbonic anhydrase inhibitor that inhibit only luminal carbonic anhydrase enzyme. (A) Methazolamide (B) Acetazolamide (C) Dichlorphenamide(D) Benzolamide
Last Answer : Answer : B
Description : All the following diuretics inhibit the carbonic anhydrase except (A) Acetazolamide (B) Bumetanide (C) Furosemide (D) Ethacrynic acid
Last Answer : Answer : D
Description : Purine biosynthesis is inhibited by (A) Aminopterin (B) Tetracyclin (C) Methotrexate (D) Chloramphenicol
Last Answer : Answer : A
Description : 3 Diffusion of drugs across cell membrane: A. Is dependent upon metabolic activity of the cell B. Is competitively inhibited by chemically related drugs C. Is affected by extent of ionization of drug molecules D. Exhibits saturation kinetics
Last Answer : C. Is affected by extent of ionization of drug molecules
Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors
Last Answer : Answer : C
Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules
Description : Zn is present as prosthetic group in this enzyme: (A) Carbonic anhydrase (B) Carboxy peptidase (C) Lactate dehydrogenase (D) All of these
Description : Zinc is a constituent of the enzyme: (A) Succinate dehydrogenase (B) Carbonic anhydrase (C) Mitochondrial superoxide dismutase (D) Aldolase
Description : Carbonic anhydrase enzyme has maximum turn over number (36 million). Minimum turn over number for an enzyme: (A) DNA polymerase (B) Lysozyme (C) Penicillase (D) Lactase dehydrogenase
Description : All of the following are iron-containing enzymes except (A) Carbonic anhydrase (B) Catalase (C) Peroxidase (D) Cytochrome oxidase
Description : All of the following are zinc-containing enzymes except (A) Acid Phosphatase (B) Alkaline Phosphatase (C) Carbonic anhydrase (D) RNA polymerase
Description : Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase
Description : Carbonic anhydrase is an example of (A) Lipoprotein (B) Phosphoprotein (C) Metalloprotein (D) Chromoprotein
Description : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is present in RBC. B- Minute quantities of
Last Answer : Which of the following statement `//` s is `//` are correct ? A- A high concentration of carbonic anhydrase is ... and D C. A,B,C and D D. Only A
Description : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide combine with water and is transported.
Last Answer : Assertion : Carbonic anhydrase is present in the erythrocytes. Reason : In erythrocytes the carbon dioxide ... A is correct and statement B is wrong.
Description : Inhibition of carbonic anhydrase results in (a) Abolition of NaHCO3 reabsorption in proximal tubule (b) Enhanced of NaHCO3 reabsorption in proximal tubule (c) Enhanced NAHCO3 secretion in distal tubule (d) None of the above
Last Answer : Ans: A
Description : An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide
Description : With regard to the transport of carbon dioxide in blood: a. 25% of carbon dioxide is dissolved in blood b. carbonic anhydrase is found in plasma c. 50% of carbon dioxide is carried as bicarbonate d. deoxygenated haemoglobin facilitates the transport of carbon dioxide
Last Answer : deoxygenated haemoglobin facilitates the transport of carbon dioxide
Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary
Last Answer : damage to the posterior pituitary
Description : Carbonic anhydrase occurs in (a) lymphocytes (b) blood plasma (c) RBCs (d) leucocytes.
Last Answer : (c) RBCs
Description : The enzyme that catalyses carbon dioxide fixation in C4 plants is (a) RuBP carboxylase (b) PEP carboxylase (c) carbonic anhydrase (d) carboxydismutase.
Last Answer : (b) PEP carboxylase
Description : In which one of the following enzymes, is copper necessarily associated as an activator? (a) Carbonic anhydrase (b) Tryptophanase (c) Lactic dehydrogenase (d) Tyrosinase
Last Answer : (d) Tyrosinase
Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide
Last Answer : D. Furosemide
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures
Last Answer : D. It is not effective in generalized tonic-clonic seizures
Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis
Last Answer : C. Inducing the synthesis of Na+ K+ ATPase
Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor
Description : Hybridoma cells are selected by culturing them in a medium containing (A) Adenine, guanine, cytosine and thymine (B) Adenine, guanine, cytosine and uracil (C) Hypoxanthine, aminopterin and thymine (D) Hypoxanthine, aminopterin and thymidine
Description : Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Description : A very efficient inhibitor of steroid biosynthesis is (A) Aminoglutethimide (B) Aminoimidazole (C) Aminoimidazolesuccinyl carboxamine (D) Aminopterin
Description : The anti-vitamin for para amino benzoic acid is (A) Aminopterin (B) Dicoumarol (C) INH (D) Sulphanomides
Description : An anti-vitamin for folic acid is (A) Aminopterin (B) Dicoumarol (C) Pyrithiamine (D) Isoniazid
Description : The anti-vitamin for para amino benzoic acid is (A) Aminopterin (B) Dicoumasol (C) Sulphanomides (D) Thiopamic acid
Description : The anti vitamin for para aminobenzoic acid is (A) Aminopterin (B) Dicoumarol (C) Sulphonamides (D) Thiopanic acid
Description : Which one of the following is characteristic of captopril and enalapril ? (a) Competitively blocks angiotensim II at its receptor (b) Decreases angiotensin II concentration in the blood (c) Decreases ... and decreases potassium in the blood (e) Decreases sodium and increases potassium in the urine
Last Answer : Ans: B
Description : A diuretic which is an aldosterone antagonist is (A) Spironolactone (B) Ethacrynic acid (C) Acetazolamide (D) Chlorothiazide
Description : An alternate substrate for orotate phosphoribosyl transferase is (A) Allopurinol (B) Xanthine (C) Hypoxanthine (D) Adenine
Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase
Description : A substrate for enzymes of pyrimidine nucleotide biosynthesis is (A) Allopurinol (B) Tetracylin (C) Chloramphenicol (D) Puromycin
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid
Last Answer : B
Description : Quantitatively, the most significant buffer system in plasma is (A) Phosphate buffer system (B) Carbonic acid-bicarbonate buffer system (C) Lactic acid-lactate buffer system (D) Protein buffer system
Description : Chloride shift is (A) H ions leaving the RBC in exchange of Cl- (B) Cl– leaving the RBC in exchange of bicarbonate (C) Bicarbonate ion returns to plasma and exchanged with chloride which shifts into the cell (D) Carbonic acid to the plasma
Description : Important buffer system of extracellular fluid is (A) Bicarbonate/carbonic acid (B) Disodium hydrogen phosphate/sodium dihydrogen phosphate (C) Plasma proteins (D) Organic Phosphate
Description : At the pH of blood 7.4, the ratio between the carbonic acid and bicarbonate fractions is (A) 1 : 10 (B) 1 : 20 (C) 1 : 30 (D) 1 : 40
Description : Respiratory alkalosis is caused by (A) An increase in carbonic acid fraction (B) A decrease in bicarbonic fraction (C) A decrease in the carbonic acid fraction (D) An increase in bicarbonate fraction
Description : Respiratory acidosis is caused by (A) Increase in carbonic acid relative to bicarbonate (B) Decrease in bicarbonate fraction (C) Increase in bicarbonate fraction (E) Decrease in the carbonic acid fraction
Description : Name the enzyme that acts both as carboxylase at one time and oxygenase at another time. (A) PEP carboxylase (B) RuBP carboxylase (C) Carbonic anyhdrase (D) None of these
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone