The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms

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Answer :  A

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Description : De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by ... synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis

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Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP

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Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

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Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

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Description : One functional sub-unit of multi-enzyme complex for de novo synthesis of fatty acids contains (A) One —SH group (B) Two —SH groups (C) Three —SH groups (D) Four —SH groups FATS AND FATTY ACID METABOLISM 87

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Description : De novo synthesis of fatty acids is catalysed by a multi-enzyme complex which contains (A) One-SH group (B) Two-SH groups (C) Three-SH groups (D) Four-SH groups

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Description : De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP

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Description : For de novo synthesis of purine nucleotides, glycine provides (A) One nitrogen atom (B) One nitrogen and one carbon atom (C) Two carbon atoms (D) One nitrogen and two carbon atoms

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Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase

Last Answer : Answer : D

Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?

Last Answer : ATP citrate lyase.

Description : What is the rate limiting enzyme of de novo synthesis of fatty acid?

Last Answer : Acetyl CoA carboxylase.

Description : The nitrogen atoms for de novo synthesis of purine nucleotides are provided by (A) Aspartate and glutamate (B) Aspartate and glycine (C) Aspartate, glutamine and glycine (D) Aspartate, glutamate and glycine

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Description : Fatty acids having chain length of 10 carbon atoms enter the (A) Portal ciruclation (B) Lacteals (C) Systemic circulation (D) Colon

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Description : Nucleotides required for the synthesis of nucleic acids can be obtained from (A) Dietary nucleic acids and nucleotides (B) De novo synthesis (C) Salvage of pre-existing bases and nucleosides (D) De novo synthesis and salvage

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Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate

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Description : All long chain fatty acids with even number of carbon atoms are oxidized to a pool of _________ by β-oxidation. (A) CO2 (B) Propionic acid (C) Acetic acid (D) Acetyl CoA

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Description : The main pathway for denovo synthesis of fatty acids occur in (A) Cytosol (B) Mitochondria (C) Microsomes (D) Nucleus

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Description : Propionyl CoA formed oxidation of fatty acids having an odd number of carbon atoms is converted into (A) Acetyl CoA (B) Acetoacetyl CoA (C) D-Methylmalonyl CoA (D) Butyryl CoA

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Description : Propionyl CoA is formed on oxidation of (A) Monounsaturated fatty acids (B) Polyunsaturated fatty acids (C) Fatty acids with odd number of carbon atoms (D) None of these FATS AND FATTY ACID METABOLISM 83

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Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased

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Description : De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these

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Description : All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase

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Description : An enzyme common to de novo synthesis of pyrimidine nucleotides and urea is (A) Urease (B) Carbamoyl phosphate synthetase (C) Aspartate transcarbamoylase (D) Argininosuccinase

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Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes

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Description : The available PRPP is used preferentially for (A) De novo synthesis of purine nucleotides (B) De novo synthesis of pyrimidine nucleotides (C) Salvage of purine bases (D) Salvage of pyrimidine bases

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Description : Xanthosine monophosphate is an intermediate during de novo synthesis of (A) TMP (B) CMP (C) AMP (D) GMP

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Description : Inosine monophophate is an intermediate during the de novo synthesis of (A) AMP and GMP (B) CMP and UMP (C) CMP and TMP (D) All of these

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Description : For de novo synthesis of purine nucleotides, aspartate provides (A) Nitrogen 1 (B) Nitrogen 3 (C) Nitrogen 7 (D) Nitrogen 9

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Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes

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Description : De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these

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Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue

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Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these

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Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

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Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates

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Description : The acetyl CoA formed on β-oxidation of all long chain fatty acids is metabolized under normal circumstances to (A) CO2 and water (B) Cholesterol (C) Fatty acids (D) Ketone bodies

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Description : Prostaglandins: a. contains 20 carbon atoms b. are unsaturated fatty acids containing a cyclopentane ring c. the different types of prostaglandins are classified according to the configuration of the cyclopentane ring d. all above

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Description : Fatty acids with odd number of carbon atoms yield acetyl-CoA and a molecule of (A) Succinyl-CoA (B) Propionyl-CoA (C) Malonyl-CoA (D) Acetoacetyl-CoA

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Description : The fatty acids containing even number and odd number of carbon atoms as well as the unsaturated fatty acids are oxidized by (A) α-oxidation (B) β-oxidation (C) ω-oxidation (D) All of these

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Description : ∆9 indicates a double bond between carbon atoms of the fatty acids: (A) 8 and 9 (B) 9 and 10 (C) 9 and 11 (D) 9 and 12

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Description : The end product of omega-oxidation of fatty acids having an even number of carbon atoms is (A) Adipic acid (B) Suberic acid (C) Both (A) and (B) (D) None of these

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Description : All the following can be oxidized by βoxidation except (A) Palmitic acid (B) Phytanic acid (C) Linoleic acid (D) Fatty acids having an odd number of carbon atoms

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Description : A pathway that requires NADPH as a cofactor is (A) Fatty acid oxidation (B) Extra mitochondrial denovo fatty acid synthesis (C) Ketone bodies formation (D) Glycogenesis

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Description : Prostaglandins have a common structure based on prostanoic acid which contains carbon atoms: (A) 12 (B) 16 (C) 18 (D) 20

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Description : Refsum’s disease results from a defect in the following pathway except (A) Alpha-oxidation of fatty acids (B) Beta-oxidation of fatty acids (C) Gamma-oxidation of fatty acids (D) Omega-oxidation of fatty acids

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