β-oxidation of fatty acids is inhibited by (A) NADPH (B) Acetyl CoA (C) Malonyl CoA (D) None of these

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Answer :

Answer :  C

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Description : β-Oxidation of odd-carbon fatty acid chain produces (A) Succinyl CoA (B) Propionyl CoA (C) Acetyl CoA (D) Malonyl CoA

Last Answer : Answer : D

Description : Fatty acids with odd number of carbon atoms yield acetyl-CoA and a molecule of (A) Succinyl-CoA (B) Propionyl-CoA (C) Malonyl-CoA (D) Acetoacetyl-CoA

Last Answer : Answer : B

Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates

Last Answer : Answer : C

Description : The acetyl CoA formed on β-oxidation of all long chain fatty acids is metabolized under normal circumstances to (A) CO2 and water (B) Cholesterol (C) Fatty acids (D) Ketone bodies

Last Answer : Answer : A

Description : All long chain fatty acids with even number of carbon atoms are oxidized to a pool of _________ by β-oxidation. (A) CO2 (B) Propionic acid (C) Acetic acid (D) Acetyl CoA

Last Answer : Answer : D

Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these

Last Answer : Answer : D

Description : De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by ... synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis

Last Answer : Answer : A

Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

Last Answer : Answer : A

Description : A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP

Last Answer : Answer : A

Description : Conversion of fatty acyl-CoA to an acylCoA derivative having 2 more carbon atoms involves as acetyl donar: (A) Acetyl-CoA (B) Succinyl-CoA (C) Propionyl-CoA (D) Malonyl-CoA

Last Answer : Answer : D

Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP

Last Answer : Answer : A

Description : The carbon chain of fatty acids is shortened by 2 carbon atoms at a time. This involves successive reactions catalysed by 4-enzymes. These act the following order: (A) Acetyl CoA dehydrogenase, ... CoA dehydrogenase (D) Enoyl hydrase, β-OH acyl CoA dehydrogenase, acyl CoA dehydrogenase, thiolose,

Last Answer : Answer : B

Description : Which of the following products of triacylglycerol breakdown and subsequent β-Oxidation may undergo gluconeogenesis? (A) Acetyl CoA (B) Porpionyl CoA (C) All ketone bodies (D) Some amino acids

Last Answer : Answer : B

Description : Propionyl CoA formed oxidation of fatty acids having an odd number of carbon atoms is converted into (A) Acetyl CoA (B) Acetoacetyl CoA (C) D-Methylmalonyl CoA (D) Butyryl CoA

Last Answer : Answer : C

Description : Link between glycolysis, Krebs’ cycle and β-oxidation of fatty acid or carbohydrate and fat metabolism is (a) oxaloacetic acid (b) succinic acid (c) citric acid (d) acetyl CoA.

Last Answer : (d) acetyl CoA.

Description : β-Oxidation of fatty acids requires all the following coenzymes except (A) CoA (B) FAD (C) NAD (D) NADP

Last Answer : Answer : D

Description : Which one of the following cofactors must be utilized during the conversion of acetyl CoA to malonyl CoA? (A) TPP (B) ACP (C) NAD+ (D) Biotin

Last Answer : Answer : D

Description : Ceramide is formed by the combination of sphingosine and (A) Acetyl-CoA (B) Acyl-CoA (C) Malonyl-CoA (D) Propionyl-CoA

Last Answer : Answer : B

Description : In extra hepatic tissues, one mechanism for utilization of acetoacetate involves (A) Malonyl-CoA (B) Succinyl-CoA (C) Propionyl-CoA (D) Acetyl-CoA

Last Answer : Answer : B

Description : The starting material for ketogenesis is (A) Acyl-CoA (B) Acetyl-CoA (C) Acetoacetyl-CoA (D) Malonyl-CoA

Last Answer : Answer : C

Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Last Answer : Answer : A

Description : Carboxylation of acetyl—CoA to malonyl — CoA takes place in presence of (A) FAD+ (B) Biotin (C) NAD+ (D) NADP+

Last Answer : Answer : C

Description : Which of the following statement regarding β-oxidation is true? (A) Requires β-ketoacyl CoA as a substrate (B) Forms CoA thioesters (C) Requires GTP for its activity (D) Yields acetyl CoA as a product

Last Answer : Answer : A

Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103

Last Answer : Answer : A

Description : As a result of each oxidation a long chain fatty acid is cleaved to give (A) An acid with 3-carbon less and propionyl CoA (B) An acid with 2-carbon less and acetyl CoA (C) An acid with 2-carbon less and acetyl CoA (D) An acid with 4-carbon and butyryl CoA

Last Answer : Answer : B

Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Last Answer : Answer : B

Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

Last Answer : Answer : D

Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate

Last Answer : Answer : D

Description : Acetyl-CoA can be formed from (A) Pyruvate (B) Fatty acids (C) ketone bodies (D) All of these

Last Answer : Answer : D

Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Last Answer : Answer : C

Description : Fatty acids can not be converted into carbohydrates in the body, as the following reaction is not possible: (A) Conversion of glucose-6-phosphate into glucose (B) Fructose 1, 6 diphosphate to ... phosphate (C) Transformation of acetyl CoA to pyruvate (D) Formation of acetyl CoA from fatty acids

Last Answer : Answer : C

Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

Last Answer : Answer : A

Description : Long chain fatty acids are first activated to acetyl-CoA in (A) Cytosol (B) Microsomes (C) Nucleus (D) Mitochondria

Last Answer : Answer : A

Description : Fatty acids cannot be converted into carbohydrates in the body as the following reaction is not possible. (A) Conversion of glucose-6-phosphate into glucose (B) Fructose 1,6-bisphosphate to fructose- ... (C) Transformation of acetyl CoA to pyruvate (D) Formation of acetyl CoA from fatty acids

Last Answer : C

Description : The protein, which is in fact a multifunctional enzyme complex in higher organism is (A) Acetyl transacylase (B) Malonyl transacylase (C) 3-Hydroxy acyl-ACP dehyratase (D) Fatty acid synthase

Last Answer : Answer : D

Description : During each cycle of β-oxidation of fatty acid, all the following compounds are generated except (A) NADH (B) H2O (C) FAD (D) Acyl CoA

Last Answer : Answer : B

Description : Mitochondrial lipogenesis requires (A) bicarbonate (B) biotin (C) acetyl CoA carboxylase (D) NADPH

Last Answer : Answer : D

Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

Last Answer : Answer : D

Description : Propionyl CoA is formed on oxidation of (A) Monounsaturated fatty acids (B) Polyunsaturated fatty acids (C) Fatty acids with odd number of carbon atoms (D) None of these FATS AND FATTY ACID METABOLISM 83

Last Answer : Answer : C

Description : NAD is required as a conenzyme in (A) Citric acid cycle (B) HMP shunt (C) β-Oxidation of fatty acids (D) Both (A) and (C)

Last Answer : Answer : D

Description : In β-Oxidation of fatty acids, which of the following are utilized as coenzymes? (A) NAD+ and NADP+ (B) FADH2 and NADH + H+ (C) FAD and FMN (D) FAD and NAD+

Last Answer : Answer : D

Description : The fatty acids containing even number and odd number of carbon atoms as well as the unsaturated fatty acids are oxidized by (A) α-oxidation (B) β-oxidation (C) ω-oxidation (D) All of these

Last Answer : Answer : B

Description : Fatty acids are oxidized by (A) α -oxidation (B) β -oxidation (C) ω -oxidation (D) All of these

Last Answer : Answer : D

Description : Which of the following can be oxidized by β-oxidation pathway? (A) Saturated fatty acids (B) Monosaturated fatty acids (C) Polyunsaturated fatty acids (D) All of these

Last Answer : Answer : D

Description : Acetoacetyl-CoA condenses with one more molecule of acetyl-CoA to form (A) Mevalonate (B) Acetoacetate (C) β-Hydroxybutyrate (D) 3-Hydroxy 3-methyl-glutaryl-CoA

Last Answer : Answer : D

Description : In synthesis of Triglyceride from α-Glycero phosphate and acetyl CoA, the first intermediate formed is (A) β-diacyl glycerol (B) Acyl carnitine (C) Monoacyl glycerol(D) Phosphatidic acid

Last Answer : Answer : D

Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex

Last Answer : Answer : B

Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase

Last Answer : Answer : B

Description : For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate

Last Answer : Answer : A

Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these

Last Answer : Answer : D