All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

1 Answer

Answer :

Answer :  D

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Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Last Answer : Answer : B

Description : Acetyl CoA carboxylase is activated by (A) Citrate (B) Insulin (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Description : Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism? (A) Allosteric regulation (B) Covalent modification (C) Induction and repression (D) All of these

Last Answer : Answer : D

Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate

Last Answer : Answer : A

Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin

Last Answer : Answer : B

Description : Sphingosine is synthesized from (A) Palmitoyl CoA and Choline (B) Palmitoyl CoA and ethanolamine (C) Palmitoyl CoA and serine (D) Acetyl CoA and choline

Last Answer : Answer : C

Description : The reaction catalysed by phosphofructokinase (A) Is activated by high concentrations of ATP and citrate (B) Uses fruitose-1-phosphate as substrate (C) Is the rate-limiting reaction of the glycolytic pathway (D) Is inhibited by fructose 2, 6-bisphosphate

Last Answer : C

Description : All of the following statements about thioredoxin reductase are true except: (A) It requires NADH as a coenzyme (B) Its substrates are ADP, GDP, CDP and UDP (C) It is activated by ATP (D) It is inhibited by dADP

Last Answer : Answer : A

Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity

Last Answer : Answer : A

Description : Insulin decreases the activity of (A) cAMP dependent protein kinase (B) HMG CoA-reductas (C) Phosphodiesterase (D) Acetyl CoA-carboxylase

Last Answer : Answer : A

Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex

Last Answer : Answer : B

Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase

Last Answer : Answer : A

Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step

Last Answer : Answer : A

Description : Carboxylation of acetyl-CoA to malonylCoA requires the enzyme: (A) Acetyl-CoA carboxylase (B) Pyruvate carboxylase (C) Acetyl transacylase (D) Acyl CoA-synthetase

Last Answer : Answer : A

Description : Biotin is a coenzyme for (A) Pyruvate carboxylase (B) Acetyl CoA carboxylase (C) Propionyl CoA carboxylase (D) All of these

Last Answer : Answer : D

Description : Mitochondrial lipogenesis requires (A) bicarbonate (B) biotin (C) acetyl CoA carboxylase (D) NADPH

Last Answer : Answer : D

Description : Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase

Last Answer : Answer : D

Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase

Last Answer : Answer : B

Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP

Last Answer : A

Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these

Last Answer : Answer : D

Description : Acetyl-CoA is the principal building block of fatty acids. It is produced within the mitochondria and does not diffuse readily into cytosol. The availability of acetyl CoA involves (A) Carnitine acyl transferase (B) Pyruvate dehydrogenase (C) Citrate lyase (D) Thiolase

Last Answer : Answer : C

Description : A carrier molecule in the citric acid cycle is (A) Acetyl-CoA (B) Citrate (C) Oxaloacetate (D) Malate

Last Answer : Answer : C

Description : The initial step of the citric acid cycle is (A) Conversion of pyruvate to acetyl-CoA (B) Condensation of acetyl-CoA with oxaloacetate (C) Conversion of citrate to isocitrate (D) Formation of α -ketoglutarate catalysed by isocitrate dehydrogenase

Last Answer : Answer : B

Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase

Last Answer : Answer : B

Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA

Last Answer : Answer : A

Description : For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate

Last Answer : Answer : A

Description : The formation of citrate from oxalo acetate and acetyl CoA is (A) Oxidation (B) Reduction (C) Condensation (D) Hydrolysis CARBOHYDRATES AND CARBOHYDRATE METABOLISM 17

Last Answer : C

Description : Before pyruvic acid enters the TCA cycle it must be converted to (A) Acetyl CoA (B) Lactate (C) α-ketoglutarate (D) Citrate

Last Answer : A

Description : Which of the following metabolite integrates glucose and fatty acid metabolism? (A) Acetyl CoA (B) Pyruvate (C) Citrate (D) Lactate

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Description : β-oxidation of fatty acids is inhibited by (A) NADPH (B) Acetyl CoA (C) Malonyl CoA (D) None of these

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Description : Which of the following products of triacylglycerol breakdown and subsequent β-Oxidation may undergo gluconeogenesis? (A) Acetyl CoA (B) Porpionyl CoA (C) All ketone bodies (D) Some amino acids

Last Answer : Answer : B

Description : Long chain fatty acids are first activated to acetyl-CoA in (A) Cytosol (B) Microsomes (C) Nucleus (D) Mitochondria

Last Answer : Answer : A

Description : The energy yield from complete oxidation of products generated by second reaction cycle of β-oxidation of palmitoyl CoA will be (A) 5 ATP (B) 12 ATP (C) 17 ATP (D) 34 ATP

Last Answer : Answer : D

Description : Oxidative degradation of acetyl CoA in the citric acid cycle gives a net yield of all the following except (A) FADH2 (B) 3 NADH (C) 2 ATP (D) 2CO2

Last Answer : Answer : C

Description : During each cycle of on going fatty acid oxidation, all the following compounds are generated except (A) H2O (B) Acetyl CoA (C) Fatty acyl CoA (D) NADH FATS AND FATTY ACID METABOLISM 103

Last Answer : Answer : A

Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones

Last Answer : Answer : A

Description : Phosphofructokinase is allosterically inhibited by (A) Fructose-1, 6-biphosphate (B) Lactate (C) Pyruvate (D) Citrate

Last Answer : Answer : D

Description : Phosphofructokinase key enzyme in glycolysis is inhibited by (A) Citrate and ATP (B) AMP (C) ADP (D) TMP

Last Answer : Answer : A

Description : Vitamin K is involved in posttranslational modification of the blood clotting factors by acting as cofactor for the enzyme: (A) Carboxylase (B) Decarboxylase (C) Hydroxylase (D) Oxidase

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Description : All the following statements about thyrotropin releasing hormone are true except (A) It is secreted by hypothalamus (B) It is a pentapeptide (C) It increases the secretion of TSH (D) Its secretion is inhibited by high level of T3 and T4 in blood

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Description : Which of the following statement regarding β-oxidation is true? (A) Requires β-ketoacyl CoA as a substrate (B) Forms CoA thioesters (C) Requires GTP for its activity (D) Yields acetyl CoA as a product

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Description : The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of ... for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol

Description : The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of ... for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamo

Description : The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate

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Description : Formation of succinyl-CoA from α-Ketoglutarate is inhibited by (A) Fluoroacetate (B) Arsenite (C) Fluoride (D) Iodoacetate

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Description : What is true about Bt toxin? (a) Bt protein exists as active toxin in the Bacillus. (b) The activated toxin enters the ovaries of the pest to sterilise it and thus prevent its multiplication. ... Bacillus has antitoxins. (d) The inactive protoxin gets converted into active form in the insect gut.

Last Answer : (d) The inactive protoxin gets converted into active form in the insect gut.

Description : All statements regarding 3-OH-3 methyl glutaryl CoA are true except (A) It is formed in the cytoplasm (B) Required in ketogenesis (C) Involved in synthesis of Fatty acid (D) An intermediate in cholesterol biosynthesis

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Description : All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct except (A) It is located on the matrix side of the inner ... inhibited by oligomycin (C) It can exhibit ATPase activity (D) It can bind molecular O2

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Description : Glucose 6-phosphate is converted to glucose 1-phosphate in a reaction catalysed by the enzyme phosphoglucomutase, which is (A) Phosphorylated (B) Dephosphorylated (C) Phosphorylated-dephosphorylated (D) Phosphorylated-dephosphorylatedrephosphorylated

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Description : Acetoacetyl-CoA condenses with one more molecule of acetyl-CoA to form (A) Mevalonate (B) Acetoacetate (C) β-Hydroxybutyrate (D) 3-Hydroxy 3-methyl-glutaryl-CoA

Last Answer : Answer : D