All the following statements about Wilson’s disease are correct except (A) It is a genetic disease (B) The defect involves copper-dependent P-type ATPase (C) Copper is deposited in liver, basal ganglia and around cornea (D) Plasma copper level is increased in it

All the following statements about Wilson’s disease are correct except (A) It is a genetic disease (B) The defect involves copper-dependent P-type ATPase (C) Copper is deposited in liver, basal ganglia and around cornea (D) Plasma copper level is increased in it
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Answer : D
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In Wilson’s disease (A) Copper fails to be excreted in the bile (B) Copper level in plasma is decreased (C) Ceruloplasmin level is increased (D) Intestinal absorption of copper is decreased

Description : In Wilson’s disease (A) Copper fails to be excreted in the bile (B) Copper level in plasma is decreased (C) Ceruloplasmin level is increased (D) Intestinal absorption of copper is decreased

Last Answer : Answer : A

All of the following are true of Wilson’s disease except (A) Low total plasma Cu (B) Elevated urinary copper (C) Arthritis (D) Aminoaciduria

Description : All of the following are true of Wilson’s disease except (A) Low total plasma Cu (B) Elevated urinary copper (C) Arthritis (D) Aminoaciduria

Last Answer : Answer : C

All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised due to increased release of the enzyme from liver cells (C) Bile salts may enter systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Last Answer : Answer : B

All the following statements about ceruloplasmin are correct except (A) It is a copper-containing protein (B) It possesses oxidase activity (C) It is synthesised in intestinal mucosa (D) Its plasma level is decreased inWilson’s disease

Description : All the following statements about ceruloplasmin are correct except (A) It is a copper-containing protein (B) It possesses oxidase activity (C) It is synthesised in intestinal mucosa (D) Its plasma level is decreased inWilson’s disease

Last Answer : Answer : C

Ceruloplasmin is absent in (A) Cirrhosis of liver (B) Wilson’s disease (C) Menke’s disease (D) Copper deficiency

Description : Ceruloplasmin is absent in (A) Cirrhosis of liver (B) Wilson’s disease (C) Menke’s disease (D) Copper deficiency

Last Answer : Answer : B

Serum ferroxidase level decreases in (A) Gaucher’s disease (B) Cirrhosis of liver (C) Acute pancreatitis (D) Wilson’s disease ENZYMES 143

Description : Serum ferroxidase level decreases in (A) Gaucher’s disease (B) Cirrhosis of liver (C) Acute pancreatitis (D) Wilson’s disease ENZYMES 143

Last Answer : Answer : D

Serum acid phosphatase level increases in (A) Metastatic carcinoma of prostate (B) Myocardial infarction (C) Wilson’s disease (D) Liver diseases

Description : Serum acid phosphatase level increases in (A) Metastatic carcinoma of prostate (B) Myocardial infarction (C) Wilson’s disease (D) Liver diseases

Last Answer : Answer : A

Which of the following diseases is associated with decreased levels of dopamine due to destruction of pigmented neuronal cells in the substantia nigra in the basal ganglia of the brain? a) Parkinson’s disease In some patients, Parkinson’s disease can be controlled; however, it cannot be cured.

Description : Which of the following diseases is associated with decreased levels of dopamine due to destruction of pigmented neuronal cells in the substantia nigra in the basal ganglia of the brain? a) ... of the central nervous system characterized by spongiform degeneration of the gray matter of the brain.

Last Answer : a) Parkinson’s disease In some patients, Parkinson’s disease can be controlled; however, it cannot be cured.

All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct except (A) It is located on the matrix side of the inner mitochondrial membrane (B) It is inhibited by oligomycin (C) It can exhibit ATPase activity (D) It can bind molecular O2

Description : All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct except (A) It is located on the matrix side of the inner ... inhibited by oligomycin (C) It can exhibit ATPase activity (D) It can bind molecular O2

Last Answer : D

There are two properties of the cell necessary to maintain nonequilibrium cellular composition; the first is selectivity and the second is energy conversion. Which of the following statement(s) is/are true concerning energy converting transport? a. The site of energy conversion and transport in the plasma membrane involves the phospholipid component b. The Na+-K++-ATPase derives energy from hydrolysis of extracellular ATP c. In some systems, energy inherent in the transmembrane ion gradient can be used to drive transport of a second species d. Examples of species transported via secondary active transport include hydrogen ions, calcium, amino acids and glucose

Description : There are two properties of the cell necessary to maintain nonequilibrium cellular composition; the first is selectivity and the second is energy conversion. Which of the following statement(s ... transported via secondary active transport include hydrogen ions, calcium, amino acids and glucose

Last Answer : Answer: c, d The selectivity of the plasma membrane, although impressive, cannot account for the nonequilibrium composition of living cells. A cell can be maintained in a nonequilibrium state only by ... to drive the transport of a second species such as protons, calcium, amino acids, or glucose

Which of the following statements about Menke’s disease are true. (A) It is an inherited disorder of copper metabolism (B) It occurs only in males (C) Plasma copper is increased in it (D) Hair becomes steely and kinky in it

Description : Which of the following statements about Menke’s disease are true. (A) It is an inherited disorder of copper metabolism (B) It occurs only in males (C) Plasma copper is increased in it (D) Hair becomes steely and kinky in it

Last Answer : Answer : C

All of the following statements about Tangier disease are true except (A) It is a disorder of HDL metabolism (B) Its inheritance is autosomal recessive (C) Apoproteins A-I and A-II are not synthesised (D) Plasma HDL is increased

Description : All of the following statements about Tangier disease are true except (A) It is a disorder of HDL metabolism (B) Its inheritance is autosomal recessive (C) Apoproteins A-I and A-II are not synthesised (D) Plasma HDL is increased

Last Answer : Answer : D

The resting membrane potential of a cell a. is dependent on the permeability of the cell membrane to K+ being greater than the permeability to Na+ b. falls to zero immediately when Na+, K+ ATPase in the membrane is inhibited c. is usually equal to the equilibrium potential for K+ d. is usually equal to the equilibrium potential for Na+ e. is markedly altered if the extracellular Na+ concentration is increased

Description : The resting membrane potential of a cell a. is dependent on the permeability of the cell membrane to K+ being greater than the permeability to Na+ b. falls to zero immediately when Na+ ... the equilibrium potential for Na+ e. is markedly altered if the extracellular Na+ concentration is increased

Last Answer : is dependent on the permeability of the cell membrane to K+ being greater than the permeability to Na+

Wilson’s disease is a condition of toxicosis of (A) Iron (B) Copper (C) Chromium (D) Molybdenum

Description : Wilson’s disease is a condition of toxicosis of (A) Iron (B) Copper (C) Chromium (D) Molybdenum

Last Answer : Answer : B

Basal ganglia dysfunction?

Description : Basal ganglia dysfunction?

Last Answer : DefinitionBasal ganglia dysfunction is a problem with the basal ganglia, the deep brain structures that help start and control movement.Causes, incidence, and risk factorsConditions that cause injury to ... to control speech, movement, and posture. A person with basal ganglia dysfunction may diffic

What are the functions of Basal Ganglia?

Description : What are the functions of Basal Ganglia?

Last Answer : Basal ganglia is Involved in cognition and voluntary movement and Diseases related to damages of this area are Parkinson's and Huntington's

General anaesthetics produce immobility in response to painful surgical stimuli by acting primarily at the: A. Motor cortex B. Basal ganglia C. Thalamus D. Spinal cord

Description : General anaesthetics produce immobility in response to painful surgical stimuli by acting primarily at the: A. Motor cortex B. Basal ganglia C. Thalamus D. Spinal cord

Last Answer : D. Spinal cord

In case of wilson’s disease, the features include all of the following except (A) Progressive hepatic cirrhosis (B) Keyser Fleisher ring (C) Aminoaciduria (D) Urinary excretion of Cu is decreased

Description : In case of wilson’s disease, the features include all of the following except (A) Progressive hepatic cirrhosis (B) Keyser Fleisher ring (C) Aminoaciduria (D) Urinary excretion of Cu is decreased

Last Answer : Answer : D

Calcitriol facilitates calcium absorption by increasing the synthesis of the following in intestinal mucosa: (A) Calcium Binding Protein (B) Alkaline Phosphatase (C) Calcium-dependent ATPase (D) All of these

Description : Calcitriol facilitates calcium absorption by increasing the synthesis of the following in intestinal mucosa: (A) Calcium Binding Protein (B) Alkaline Phosphatase (C) Calcium-dependent ATPase (D) All of these

Last Answer : Answer : D

All of the following statements about bronzed diabetes are true except (A) It is caused by excessive intake of copper (B) Skin becomes pigmented (C) There is damage to β cells of Islets of Langerhans (D) Liver is damaged

Description : All of the following statements about bronzed diabetes are true except (A) It is caused by excessive intake of copper (B) Skin becomes pigmented (C) There is damage to β cells of Islets of Langerhans (D) Liver is damaged

Last Answer : Answer : A

All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease

Description : All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease

Last Answer : Answer : C

All the following statements about restriction fragment length polymorphism are true except (A) It results from mutations in restriction sites (B) Mutations in restriction sites can occur in coding or non-coding regions of DNA (C) It is inherited in Mendelian fashion (D) It can be used to diagnose any genetic disease

Description : All the following statements about restriction fragment length polymorphism are true except (A) It results from mutations in restriction sites (B) Mutations in restriction sites can occur in coding or non- ... It is inherited in Mendelian fashion (D) It can be used to diagnose any genetic disease

Last Answer : Answer : D

All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers

Description : All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers

Last Answer : Answer : B

Menke’s disease (Kinky or steel hair disease) is a X-linked disease characterized by (A) High levels of plasma copper (B) High levels of ceruloplasmin (C) Low levels of plasma copper and of ceuloplasmin (D) High level of hepatic copper

Description : Menke’s disease (Kinky or steel hair disease) is a X-linked disease characterized by (A) High levels of plasma copper (B) High levels of ceruloplasmin (C) Low levels of plasma copper and of ceuloplasmin (D) High level of hepatic copper

Last Answer : Answer : C

Refsum’s disease results from a defect in the following pathway except (A) Alpha-oxidation of fatty acids (B) Beta-oxidation of fatty acids (C) Gamma-oxidation of fatty acids (D) Omega-oxidation of fatty acids

Description : Refsum’s disease results from a defect in the following pathway except (A) Alpha-oxidation of fatty acids (B) Beta-oxidation of fatty acids (C) Gamma-oxidation of fatty acids (D) Omega-oxidation of fatty acids

Last Answer : Answer : A

______ is the defect which occurs in eye due to excessive curvature of cornea and person is not able to see distant objects clearly . a)myopia b)hypermetropia c)squint d)cataract

Description : ______ is the defect which occurs in eye due to excessive curvature of cornea and person is not able to see distant objects clearly . a)myopia b)hypermetropia c)squint d)cataract

Last Answer : a)myopia

hat is/are the consequence(s) of myocardial Na+ K+ ATPase inhibition by digoxin: A. Increased intracellular Na+ ion concentration B. Increased cytosolic Ca2+ ion concentration C. Increased intracellular K+ ion concentration D. Both ‘A’ and ‘B’ are correct

Description : hat is/are the consequence(s) of myocardial Na+ K+ ATPase inhibition by digoxin: A. Increased intracellular Na+ ion concentration B. Increased cytosolic Ca2+ ion concentration C. Increased intracellular K+ ion concentration D. Both ‘A’ and ‘B’ are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

An important finding in glycinuria is (A) Excess excretion of oxalate in the urine (B) Deficiency of enzyme glycinase (C) Significantly increased serum glycine level (D) Defect in renal tubular reabsorption of glycine

Description : An important finding in glycinuria is (A) Excess excretion of oxalate in the urine (B) Deficiency of enzyme glycinase (C) Significantly increased serum glycine level (D) Defect in renal tubular reabsorption of glycine

Last Answer : Answer : D

Keratan sulphate is found in abundance in (A) Heart muscle (B) Liver (C) Adrenal cortex (D) Cornea

Description : Keratan sulphate is found in abundance in (A) Heart muscle (B) Liver (C) Adrenal cortex (D) Cornea

Last Answer : D

All the following statements about recognition of a codon on mRNA by an anticodon on tRNA are correct except (A) The recognition of the third base of the codon is not very precise (B) Imprecise recognition of the third base results in wobble (C) Wobble is partly responsible for the degeneracy of the genetic code (D) Wobble results in incorporation of incorrect amino acids in the protein

Description : All the following statements about recognition of a codon on mRNA by an anticodon on tRNA are correct except (A) The recognition of the third base of the codon is not very precise (B) ... degeneracy of the genetic code (D) Wobble results in incorporation of incorrect amino acids in the protein

Last Answer : Answer : D

All the following statements about genetic code are correct except (A) It is degenerate (B) It is unambigous (C) It is nearly universal(D) It is overlapping

Description : All the following statements about genetic code are correct except (A) It is degenerate (B) It is unambigous (C) It is nearly universal(D) It is overlapping

Last Answer : Answer : D

Zinc deficiency occurs commonly in (A) Acrodermatitis enteropathica (B) Wilson’s disease (C) Xeroderma pigmentosum (D) Menke’s disease

Description : Zinc deficiency occurs commonly in (A) Acrodermatitis enteropathica (B) Wilson’s disease (C) Xeroderma pigmentosum (D) Menke’s disease

Last Answer : Answer : D

Accumulation of trytophan in blood is known as (A) Pompe’s disease (B) Wilson’s disease (C) Wolman’s disease (D) Hartnup’s disease

Description : Accumulation of trytophan in blood is known as (A) Pompe’s disease (B) Wilson’s disease (C) Wolman’s disease (D) Hartnup’s disease

Last Answer : Answer : D

All the following statements about renal tubular acidosis are correct except (A) Renal tubules may be unable to reabsorb bicarbonate (B) Renal tubules may be unable to secrete hydrogen ions (C) Plasma chloride is elevated (D) Anion gap is decreased

Description : All the following statements about renal tubular acidosis are correct except (A) Renal tubules may be unable to reabsorb bicarbonate (B) Renal tubules may be unable to secrete hydrogen ions (C) Plasma chloride is elevated (D) Anion gap is decreased

Last Answer : Answer : D

Choose the correct statement about nicotine: A. It selectively stimulates parasympathetic ganglia B. It has no clinical application C. It is used as an aid during smoking cessation D. It is used in Alzheimer's disease

Description : Choose the correct statement about nicotine: A. It selectively stimulates parasympathetic ganglia B. It has no clinical application C. It is used as an aid during smoking cessation D. It is used in Alzheimer's disease

Last Answer : C. It is used as an aid during smoking cessation

With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the formation of red blood cell membranes. 3) Chylomicrons are synthesized in the liver. 4) HDL is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

Description : With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the ... is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.

With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the formation of red blood cell membranes. 3) Chylomicrons are synthesized in the liver. 4) HDL is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

Description : With respect to lipoprotein transport and metabolism in the body, the following statements are correct EXCEPT: 1) Arterial walls contain cells with LDL receptors. 2) Cholesterol is required for the ... is assembled in the extracellular space. 5) VLDL transformation to LDL occurs in adipose tissue.

Last Answer : Answers-3 Chylomicrons are formed in the gut from exogenous triacylglycerols and cholesterol. They are released into the lymph and thereby enter the blood.They are not formed in the liver.

The following metabolic abnormalities occur in Diabetes mellitus except (A) Increased plasma FFA (B) Increased pyruvate carboxylase activate (C) Decreased lipogenesis (D) Decreased gluconeogenesis

Description : The following metabolic abnormalities occur in Diabetes mellitus except (A) Increased plasma FFA (B) Increased pyruvate carboxylase activate (C) Decreased lipogenesis (D) Decreased gluconeogenesis

Last Answer : B

The following occur in untreated insulin dependent diabetes mellitus: a. diuresis b. decreased plasma amino acid c. increased plasma fatty acid d. ketonuria

Description : The following occur in untreated insulin dependent diabetes mellitus: a. diuresis b. decreased plasma amino acid c. increased plasma fatty acid d. ketonuria

Last Answer : ketonuria

The endothelium: a. maintains the integrity of the corneal stroma through an ATP-Na+, K+-dependent pump b. receives its nutrient from the blood vessels surrounding the cornea c. undergoes multiplication in response to trauma d. contains tight junction between adjacent endothelium

Description : The endothelium: a. maintains the integrity of the corneal stroma through an ATP-Na+, K+-dependent pump b. receives its nutrient from the blood vessels surrounding the cornea c. undergoes multiplication in response to trauma d. contains tight junction between adjacent endothelium

Last Answer : maintains the integrity of the corneal stroma through an ATP-Na+, K+-dependent pump

All of the following statements about RNA-dependent DNA polymerase are true except: (A) It synthesizes DNA using RNA as a template (B) It is also known as reverse transcriptase (C) It synthesizes DNA in 5’→3’ direction (D) It is present in all the viruses

Description : All of the following statements about RNA-dependent DNA polymerase are true except: (A) It synthesizes DNA using RNA as a template (B) It is also known as reverse transcriptase (C) It synthesizes DNA in 5’→3’ direction (D) It is present in all the viruses

Last Answer : Answer : D

Impaired galactose tolerance test suggests (A) Defect in glucose utilisation (B) Liver cell injury (C) Renal defect (D) Muscle injury

Description : Impaired galactose tolerance test suggests (A) Defect in glucose utilisation (B) Liver cell injury (C) Renal defect (D) Muscle injury

Last Answer : Answer : B

In our society women are blamed for producing female children. Choose the correct answer for the sex-determination in humans. (a) Due to some defect like aspermia in man. (b) Due to the genetic make up of the particular sperm which fertilises the egg. (c) Due to the genetic make up of the egg. (d) Due to some defect in the women.

Description : In our society women are blamed for producing female children. Choose the correct answer for the sex-determination in humans. (a) Due to some defect like aspermia in man. (b) Due to the genetic make up of the ... . (c) Due to the genetic make up of the egg. (d) Due to some defect in the women.

Last Answer : (b) Due to the genetic make up of the particular sperm which fertilises the egg.

True statements about EOG (electro-oculogram) include: a. the EOG light-peak to dark-trough ratio is reduced in central retinal vein occlusion b. the light peak of EOG is abnormal in Best's disease c. the EOG light rise is produced by depolarization of the basal membrane of the retinal pigment epithelium d. all above

Description : True statements about EOG (electro-oculogram) include: a. the EOG light-peak to dark-trough ratio is reduced in central retinal vein occlusion b. the light peak of EOG is abnormal in Best' ... rise is produced by depolarization of the basal membrane of the retinal pigment epithelium d. all above

Last Answer : all above

Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells C. Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Last Answer : D. All of the above

All the following statements about phenylketonuria are correct except (A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and phenyllactate is increased (C) It can be controlled by giving a lowphenylalanine diet (D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin

Description : All the following statements about phenylketonuria are correct except (A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and phenyllactate is increased (C) It ... diet (D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin

Last Answer : Answer : D

All the following statements about TSH are true except (A) It is a glycoprotein (B) It is made up of α- and β-subunits (C) Receptor recognition involves both the subunits (D) Its subunit is identical with those of FSH and LH

Description : All the following statements about TSH are true except (A) It is a glycoprotein (B) It is made up of α- and β-subunits (C) Receptor recognition involves both the subunits (D) Its subunit is identical with those of FSH and LH

Last Answer : Answer : D

A 65-year old patient has colon carcinoma metastatic to the liver and lungs. He has had a weight loss of 10 kg. Cytokine-dependent tumor cachexia is attributable to which of the following? a. Increased glucose uptake and increased glycogen breakdown occur in this circumstance. b. Suppressed activity of lipoprotein lipase results from TNFa c. TNFa stimulates lipolysis d. The differentiation process of pre-adipocytes is impaired e. Partial reversal of differentiated adipocytes to pre-adipocyte morphology and gene expression occurs

Description : A 65-year old patient has colon carcinoma metastatic to the liver and lungs. He has had a weight loss of 10 kg. Cytokine-dependent tumor cachexia is attributable to which of the ... is impaired e. Partial reversal of differentiated adipocytes to pre-adipocyte morphology and gene expression occurs

Last Answer : Answer: a, b, c, d, e Tumor cachexia appears to be mediated by TNFa. Lipopolysaccharide (LPS), as well as other cytokines, activate a variety of inflammatory cells, most ... chronic syndromes of anorexia, weight loss, and cachexia that are associated with both chronic infection and malignancy

Each of the following is the Clinical manifestations of right sided heart failure EXCEPT: C A. dependent oedema B. ascites C. pulmonary oedema D. nutmeg liver

Description : Each of the following is the Clinical manifestations of right sided heart failure EXCEPT: C A. dependent oedema B. ascites C. pulmonary oedema D. nutmeg liver

Last Answer : pulmonary oedema