Description : In case of wilson’s disease, the features include all of the following except (A) Progressive hepatic cirrhosis (B) Keyser Fleisher ring (C) Aminoaciduria (D) Urinary excretion of Cu is decreased
Last Answer : Answer : D
Description : All the following statements about Wilson’s disease are correct except (A) It is a genetic disease (B) The defect involves copper-dependent P-type ATPase (C) Copper is deposited in liver, basal ganglia and around cornea (D) Plasma copper level is increased in it
Description : Which of the following is true concerning a 68 year old male with type 2 diabetes diagnosed with type IV renal tubal acidosis? 1) Aminoaciduria would be expected. 2) Fludrocortisone treatment is effective ... 4) Increased urinary bicarbonate would be expected. 5) Normal renal handling of K+ and H+
Last Answer : Answers-2 H+ secretion, sodium reabsorption and ammonia production diminishes. RTA 4 is in effect hyporeninaemic hypoaldosteronism or failure of aldosterone action and thus helped treated with ... particularly. Aminoaciduria and increased urine bicarbonate are features of RTA types 1 and 2.
Description : In Wilson’s disease (A) Copper fails to be excreted in the bile (B) Copper level in plasma is decreased (C) Ceruloplasmin level is increased (D) Intestinal absorption of copper is decreased
Last Answer : Answer : A
Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males
Last Answer : Answer : C
Description : All the following statements about renal tubular acidosis are correct except (A) Renal tubules may be unable to reabsorb bicarbonate (B) Renal tubules may be unable to secrete hydrogen ions (C) Plasma chloride is elevated (D) Anion gap is decreased
Description : Wilson’s disease is a condition of toxicosis of (A) Iron (B) Copper (C) Chromium (D) Molybdenum
Last Answer : Answer : B
Description : Ceruloplasmin is absent in (A) Cirrhosis of liver (B) Wilson’s disease (C) Menke’s disease (D) Copper deficiency
Description : A characteristic of pheochromocytoma is elevated urinary excretion of (A) Dopamine (B) Tyrosine (C) Vinylmandelic acid (D) Phenylalanine
Description : All the following statements about ceruloplasmin are correct except (A) It is a copper-containing protein (B) It possesses oxidase activity (C) It is synthesised in intestinal mucosa (D) Its plasma level is decreased inWilson’s disease
Description : A 55 year-old female complaining of vague tiredness is found to have a serum corrected calcium concentration of 2.9 mmol/l. Examination was unremarkable. Which of the following results ... 4) Low normal plasma phosphate concentration 5) Low normal serum 25-hydroxyvitamin D concentration
Last Answer : Answers-3 Bit too easy really. A high or even normal PTH concentration in the presence of hypercalcaemia would support the diagnosis of hyperparathyroidism. A high urinary Calcium concentration may ... but neither confirm the diagnosis. Elevated 1,25 VitD suggests a diagnosis of hypervitaminosis D.
Description : Menke’s disease (Kinky or steel hair disease) is a X-linked disease characterized by (A) High levels of plasma copper (B) High levels of ceruloplasmin (C) Low levels of plasma copper and of ceuloplasmin (D) High level of hepatic copper
Description : All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive
Description : Which of the following manifestations is often the earliest sign of malignant hyperthermia? a) Tachycardia (heart rate above 150 beats per minute) Tachycardia is often the earliest sign of malignant ... develops rapidly. d) Oliguria Scant urinary output is a later sign of malignant hyperthermia.
Last Answer : a) Tachycardia (heart rate above 150 beats per minute) Tachycardia is often the earliest sign of malignant hyperthermia.
Description : Elevated plasma level of the following projects against atherosclerosis: (A) Chylomicrons (B) VLDL (C) HDL (D) LDL
Description : Which of the following statements about Menke’s disease are true. (A) It is an inherited disorder of copper metabolism (B) It occurs only in males (C) Plasma copper is increased in it (D) Hair becomes steely and kinky in it
Description : Zinc deficiency occurs commonly in (A) Acrodermatitis enteropathica (B) Wilson’s disease (C) Xeroderma pigmentosum (D) Menke’s disease
Description : Serum ferroxidase level decreases in (A) Gaucher’s disease (B) Cirrhosis of liver (C) Acute pancreatitis (D) Wilson’s disease ENZYMES 143
Description : Serum acid phosphatase level increases in (A) Metastatic carcinoma of prostate (B) Myocardial infarction (C) Wilson’s disease (D) Liver diseases
Description : Accumulation of trytophan in blood is known as (A) Pompe’s disease (B) Wilson’s disease (C) Wolman’s disease (D) Hartnup’s disease
Description : All of the following statements about Tangier disease are true except (A) It is a disorder of HDL metabolism (B) Its inheritance is autosomal recessive (C) Apoproteins A-I and A-II are not synthesised (D) Plasma HDL is increased
Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase
Description : All the following are true about phenylketonuria except (A) Deficiency of phenylalanine hydroxylase (B) Mental retardation (C) Increased urinary excretion of p-hydroxyphenyl pyruvic acid (D) Decrease serotonin formation
Description : An early diagnosis of vitamin C deficiency can be made by (A) Measuring plasma ascorbic acid (B) Measuring urinary ascorbic acid (C) Ascorbic acid saturation test (D) All of these
Description : LDH1 and LDH2 are elevated in (A) Myocardial infarction (B) Liver disease (C) Kidney disease (D) Brain disease
Description : The isoenzymes LDH5 is elevated in (A) Myocardial infarction (B) Peptic ulcer (C) Liver disease (D) Infectious diseases
Description : A 68-year-old male who underwent a repair of an abdominal aortic aneurysm 5 days ago, develops tachycardia, tachypnea, hypotension with cool, pale, mottled cyanotic extremities. He ... use of moderate doses of inotropic agents e. Afterload reduction with nitroprusside is absolutely contraindicated
Last Answer : Answer: a, b, d Intrinsic cardiogenic shock results from failure of the heart as an effective pump. Coronary artery disease is the most common cause of myocardial ... hemodynamic monitoring. Infusion of afterload-reducing agents can be administered in conjunction with inotropic support
Description : Haematuria can occur in all of the following except (A) Acute glomerulonephritis (B) Cancer of urinary tract (C) Stone in urinary tract (D) Mismatched blood transfusion
Description : All the following statements about phenylketonuria are correct except (A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and phenyllactate is increased (C) It ... diet (D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin
Description : Wilson's disease is an inherited disorder in which excessive amounts of ________ accumulate in the body.
Last Answer : Copper
Description : An inherited or acquired renal tubular defect in the reabsorption of phosphate (Vit D resistant ricket) is characterized with (A) Normal serum Phosphate (B) High serum phosphate (C ... blood phosphorous with elevated alkaline Phosphate (D) A high blood phosphorous with decreased alkaline phosphatase
Description : All of the following can occur in LeschNyhan syndrome except (A) Gouty arthritis (B) Uric acid stones (C) Retarted growth (D) Self-mutiliating behaviour
Description : The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation ... in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections
Last Answer : A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble
Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate
Description : All the following statements about hormones are true except (A) All of them require specific carriers in plasma (B) All of them require specific receptors in target cells (C) Some of them are subject to feedback regulation (D) Some of them increase the transcription of certain genes
Description : Pentosuria is a rare hereditary disease is characterized by increased urinary excretion of (A) L-xylulose (B) Xylitol (C) Xylulose 5-phosphate (D) Ribose 5-phosphate
Description : Increased urinary indole acetic acid is diagnostic of (A) Maple syrup urine disease (B) Hartnup disease (C) Homocystinuia (D) Phenylketonuria
Description : Plasma non-functional enzymes are (A) totally absent (B) low concentration in plastic (C) important for diagnosis of several disease (D) All of these
Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria
Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.
Description : A middle aged female presented with following symptoms - Hirsutism, fragility of skin, with easy bruising, broad purplish striae and signs of proximal myopathy. The first step in ... Exclude exogenous Glucocorticoid use 3) Advice plasma ACTH estimation 4) Advice dexamethasone overnight test
Last Answer : Correct Answer: 2) Exclude exogenous Glucocorticoid use
Description : Urinary 17 ketosteroids (A) Are not found in women (B) Reflect the total production of androgenic substances (C) Indicate the total production of sex hormone (D) Are highly active androgens
Description : In hepatic diseases (A) Both the bound iron and total iron binding capacity of the plasma may be low (B) Both the bound iron and total iron binding capacity of the plasma may be high (C) Only bound iron may be high (D) Only the total iron binding capacity may be high
Description : In iron deficiency anemia (A) The plasma bound iron is low (B) The plasma bound iron is high (C) Total iron binding capacity is low (D) Both the plasma bound iron and total iron binding capacity are low
Description : In Vitamin D poisoning (hyper-vitaminosis) (A) Both serum and urinary “Ca” (B) The serum Ca is low and urinary calcium high (C) The serum “Ca” is increased and urinary “Ca” is normal (D) Both serum and urinary “Ca” are low
Description : All of the following statements about bronzed diabetes are true except (A) It is caused by excessive intake of copper (B) Skin becomes pigmented (C) There is damage to β cells of Islets of Langerhans (D) Liver is damaged
Description : Which of the following reactions is not involved in extraction of Cu from copper pyrite ?
Last Answer : Which of the following reactions is not involved in extraction of Cu from copper pyrite ? A. `Cu_(2)S * Fe_(2 ... 2)` D. `FeO+ SiO_(2) rarr FeSiO_(3)`
Description : Ammonia forms the complex `[Cu(NH_3)_4]^(2+)` with copper ions in alkaline solution but not in acid solution. The reasons for it is:
Last Answer : Ammonia forms the complex `[Cu(NH_3)_4]^(2+)` with copper ions in alkaline solution but not in ... ` ions and `NH_(3)` molecules are not available.
Description : Which of the following can be purified by the electrolytic method? (a) Sodium (Na) (b) Copper (Cu) (c) Boron (B) (d) Chlorine (C12)
Last Answer : Ans:129
Description : Copper substances when exposed to air gains a green coating due to the formation of: (1) CuO (2) CuCO3 Cu(OH)2 (3) CuSO4 (4) Cu(NO3)2
Last Answer : (2) CuCO3 Cu(OH)2 Explanation: When copper is exposed to air, it reacts with moist carbon dioxide in the air and slowly loses its shiny brown surface and gains a green coat. This green substance is ... Cu(OH)2). The formation of this green coating on the surface of a copper object corrodes it.
Description : Cu ions released from copper-releasing intra uterine devices (IUDs) (a) make uterus unsuitable for implantation (b) increase phagocytosis of sperms (c) suppress sperm motility (d) prevent ovulation.
Last Answer : suppress sperm motility