Description : All the following statements about phenylketonuria are correct except (A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and phenyllactate is increased (C) It ... diet (D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin
Last Answer : Answer : D
Description : A 53-year-old man presented with hypertension of 150/110 mmHg. He is generally asymptomatic and has no previous medical history of note. He is a smoker of 5 cigarettes daily and drinks ... Adrenocortical adenoma 2) Bartter's syndrome 3) Liddle's syndrome 4) Liquorice ingestion 5) Pheochromocytoma
Last Answer : Answers-1 This patient is most likely to have Conn's syndrome as reflected by the hypokalaemic hypertension. Liquorice ingestion or Liddle's syndrome are again possible causes of ... hypertension (often diastolic hypertension), muscular weakness, paresthesias, headache, polyuria, and polydipsia."
Description : For Catecholamine biosynthesis the rate limiting enzyme is (A) DOPA decarboxylase (B) DOPAMINE β-hydroxylase (C) Tyrosine hydroxylase (D) Phenylalanine hydroxylase
Last Answer : Answer : C
Description : The rate limiting step in the biosynthesis of catecholamines is (A) Decarboxylation of dihydroxyphenylalanine (B) Hydroxylation of phenylalanine (C) Hydroxylation of tyrosine (D) Oxidation of dopamine
Description : All the following are true about phenylketonuria except (A) Deficiency of phenylalanine hydroxylase (B) Mental retardation (C) Increased urinary excretion of p-hydroxyphenyl pyruvic acid (D) Decrease serotonin formation
Description : Tyrosine hydroxylase is inhibited by (A) Catecholamines (B) α−Methyldopa (C) Phenylalanine (D) Vanillyl mandelic acid
Last Answer : Answer : A
Description : Thyroid hormones are synthesized by the iodination of the amino acid: (A) Glycine (B) Phenylalanine (C) Alanine (D) Tyrosine
Description : Albinism is due to deficiency of the enzyme: (A) Phenylalanine hydroxylase (B) Tyrosinase (C) p-Hydroxyphenylpyruvic acid oxidase (D) Tyrosine dehydrogenase
Description : Activation or inactivation of certain key regulatory enzymes is accomplished by covalent modification of the amino acid: (A) Tyrosine (B) Phenylalanine (C) Lysine (D) Serine
Description : Which one of the following is an essential amino acid? (A) Arginine (B) Tyrosine (C) Phenylalanine (D) Proline
Description : The limiting amino acid of rice is (A) Lysine (B) Tryptophan (C) Phenylalanine (D) Tyrosine
Description : Million-Nasse’s reaction is specific for the amino acid: (A) Tryptophan (B) Tyrosine (C) Phenylalanine (D) Arginine
Last Answer : Answer : B
Description : Which of the following is a characteristic feature of acute intermittent porphyria? 1) autosomal recessive inheritance 2) excessive faecal protoporphyrin excretion 3) excessive urinary porphobilinigoen between acute attacks 4) hypernatraemia during attacks 5) photosensitivity
Last Answer : Answers-3 Features of acute intermittent porphyria include urinary porphobilinogen excretion raised between attacks, hyponatraemia during an acute attack and autosomal dominant inheritance.
Description : The rate limiting step in catecholamine synthesis is catalysed by (A) Phenylalanine hydroxylase (B) Tyrosine hydroxylase (C) Dopa decarboxylase (D) Phenylethanolamine N-methyl transferase
Description : Melatonin is synthesised from (A) Phenylalanine (B) Tyrosine (C) Tryptophan (D) None of these
Description : Neonatal tyrosinemia is due to deficiency of the enzyme: (A) p-Hydroxyphenylpyruvate hydroxylase (B) Fumarylacetoacetate hydrolase (C) Phenylalanine hydroxylase (D) Tyrosine dehydrogenase
Description : Niacin can be synthesised in human beings from (A) Histidine (B) Phenylalanine (C) Tyrosine (D) Tryptophan
Description : Richner-Hanhart syndrome is due to defect in (A) Tyrosinase (B) Phenylalanine hydroxylase (C) Hepatic tyrosine transaminase (D) Fumarylacetoacetate hydrolase
Description : Million’s test is positive for (A) Phenylalanine (B) Glycine (C) Tyrosine (D) Proline
Description : Serotonin is synthesised from (A) Serine (B) Phenylalanine (C) Tyrosine (D) Tryptophan
Description : Phenylalanine is the precursor of (A) L-DOPA (B) Histamine (C) Tyrosine (D) Throxine
Last Answer : C
Description : Small amount of urinary oxalates is contributed by the amino acid: (A) Glycine (B) Tyrosine (C) Alanine (D) Serine
Description : In the synthetic pathway of epinephrine, disulfiram (antabuse) inhibits the enzyme: (A) Tyrosine hydroxylase (B) Dopamine β-hydroxylase (C) DOPA decarboxylase (D) N-methyl transferase
Description : Increased urinary excretion of orotic acid can occur in deficiency of (A) Orotate phosphoribosyl transferase (B) OMP decarboxylase (C) Mitochondrial ornithine transcarbamoylase (D) Any of the above
Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase
Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males
Description : Urinary excretion of vanillyl madelic acid is increased in (A) Phaeochromocytoma (B) Cushing’s syndrome (C) Carcinoid syndrome (D) Aldosteronism
Description : A biochemical indication of vitamin B12 deficiency can be obtained by measuring the urinary excretion of (A) Pyruvic acid (B) Malic acid (C) Methyl malonic acid (D) Urocanic acid
Description : Laboratory diagnosis of vitamin B12 deficiency can be made by measuring the urinary excretion of (A) Xanthurenic acid (B) Formiminoglutamic acid (C) Methylmalonic acid (D) Homogentisic acid
Description : Pyridoxine deficiency can be diagnosed by measuring the urinary excretion of xanthurenic acid following a test dose of (A) Glycine (B) Histidine (C) Tryptophan (D) Pyridoxine
Description : Pyridoxine deficiency can be diagnosed by measuring urinary excretion of (A) Pyruvic acid (B) Oxaloacetic acid (C) Xanthurenic acid (D) None of these VITAMINS 119
Description : Folic acid deficiency can be diagnosed by increased urinary excretion of (A) Methylmalonate (B) Figlu (C) Cystathionine (D) Creatinine
Description : Following events occur in the cytoplasm and not inside storage vesicles, except (a) Conversion of tyrosine to dopa (b) Conversion of dopa to dopamine (c) Conversion of dopamine to norepinephrine (d) Conversion of dopamine to 3,4 dihydroxy phenyl acetic acid
Last Answer : Ans: C
Description : All of the following are true of Wilson’s disease except (A) Low total plasma Cu (B) Elevated urinary copper (C) Arthritis (D) Aminoaciduria
Description : .Khorana first deciphered the triplet codons of (a) serine and isoleucine (b) cysteine and valine (c) tyrosine and tryptophan (d) phenylalanine and methinonine.
Last Answer : (a) serine and isoleucine
Description : Khorana first deciphered the triplet codons of (a) serine and isoleucine (b) cysteine and valine (c) tyrosine and tryptophan (d) phenylalanine and methinonine
Last Answer : (b) cysteine and valine
Last Answer : (D) Tryptophan
Description : In case of wilson’s disease, the features include all of the following except (A) Progressive hepatic cirrhosis (B) Keyser Fleisher ring (C) Aminoaciduria (D) Urinary excretion of Cu is decreased
Description : Daily urinary urobilinogen excretion in adult men is (A) 0–4 mg (B) 5–8 mg (C) 9–12 mg (D) 13–20 mg
Description : Pentosuria is a rare hereditary disease is characterized by increased urinary excretion of (A) L-xylulose (B) Xylitol (C) Xylulose 5-phosphate (D) Ribose 5-phosphate
Description : Vitamin B12 deficiency can be diagnosed by urinary excretion of (A) Pyruvate (B) Methylmalonate (C) Malate (D) Lactate
Description : In glycinuria daily urinary excretion of glycine ranges from (A) 100–200 mg (B) 300–500 mg (C) 600–1000 mg (D) 1100–1400 mg
Description : The following are true about the neurotransmitters: a. acetylcholine is inactivated mainly by presynaptic reuptake b. tyrosine is essential for the formation of dopamine c. noradrenaline is inactivated mainly by hydrolysis d. adrenaline is formed from methylation of the noradrenaline
Last Answer : adrenaline is formed from methylation of the noradrenaline
Description : True statements about the following neurotransmitters include: a. dopamine is formed from tyrosine b. in the synapse, noradrenaline is inactivated by active reuptake into the presynpatic terminals c. noradrenaline is formed by hydroxylation of dopamine d. all above
Last Answer : all above
Description : The rate limiting enzyme in the synthesis of catecholamines is: A. Tyrosine hydroxylase B. Dopa decarboxylase C. Dopamine β-hydroxylase D. Noradrenaline N-methyl transferase
Last Answer : A. Tyrosine hydroxylase
Description : Pyridoxine deficiency can be diagnosed by measuring urinary excretion of (A) Pyruvic acid (B) Oxaloacetic acid (C) Xanthurenic acid (D) None of these
Last Answer : (C) Xanthurenic acid
Description : Which of the following enzyme defects is associated with a characteristic body odour? 1) Phenylalanine aminotransferase 2) Galactose0-phosphate-uridyltransferase 3) Ornithine transcarbamylase deficiency 4) Fumaryl acetoacetase 5) Branched chain ketoacid decarboxylase
Last Answer : Answers-5 The following inborn errors of amino acid metabolism are associated with abnormal odours: Glutaric acidaemia type II (sweaty feet), hawkinsinuria (swimming pool), isovaleric acidaemia (sweaty feet), ... The general rule is that if a child smells peculiar he requires a metabolic work-up.
Description : Excretion of `Na^(+)` in urine is elevated by `:-`
Last Answer : Excretion of `Na^(+)` in urine is elevated by `:-` A. ANF B. ADH C. ACTH D. Aldosterone
Description : Which of the following manifestations is often the earliest sign of malignant hyperthermia? a) Tachycardia (heart rate above 150 beats per minute) Tachycardia is often the earliest sign of malignant ... develops rapidly. d) Oliguria Scant urinary output is a later sign of malignant hyperthermia.
Last Answer : a) Tachycardia (heart rate above 150 beats per minute) Tachycardia is often the earliest sign of malignant hyperthermia.