Description : Which of the following is used for inducing labour? (A) Prostaglandins (B) Prostacyclins (C) Vasopressin (D) Thromboxanes
Last Answer : Answer : A
Description : Slow reacting Substance of Anaphylaxis is a mixture of (A) Prostaglandins (B) Prostacyclins (C) Thromboxanes (D) Leukotrienes
Last Answer : Answer : D
Description : Cyclo-oxygenase is involved in the synthesis of (A) Prostaglandins (B) Thromboxanes (C) Both (A) and (B) (D) None of these
Last Answer : Answer : C
Description : Lipo-oxygenase is required for the synthesis of (A) Prostaglandins (B) Leukotrienes (C) Thromboxanes (D) All of these
Last Answer : Answer : B
Description : Anti-inflammatory corticosteroids inhibit the synthesis of (A) Leukotrienes (B) Prostaglandins (C) Thromboxanes (D) All of these
Description : True statements regarding eicosanoids include which of the following? A. Prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase pathway. B. The vasoconstricting, platelet-aggregating, ... prostaglandins have a short circulation half-life and exert most of their effects locally.
Last Answer : Answer: ABD DISCUSSION: The eicosanoids are a group of compounds arising from the metabolism of arachidonic acid. The prostaglandins and thromboxanes are synthesized via the cyclo-oxygenase ... effects and may be involved in the physiologic responses associated with anaphylactic and septic shock
Description : Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these
Description : Eicosanoids mediate inflammation in a variety of ways. Of the following statements, which are true with regard to this? a. Eicosanoids are stored in cytoplasmic granules ... include vasodilatation, vasoconstriction, increased vascular permeability and both chemotaxis and chemoattractant inhibition
Last Answer : Answer: b, d The eicosanoids are derived from arachidonic acid (eicosatetraenoic acid) and consist of prostaglandins, thromboxanes, leukotrienes and lipoxins. The eicosanoids are not ... nervous system d. Mononuclear phagocytes release a variety of proinflammatory cytokines and growth factors
Description : One of the important functions of prostacyclins is (A) Inhibition of platelet aggregation (B) Contraction of uterus (C) Decrease of gastric secretion (D) Relieving osthma
Description : A cup of strong coffee would be expected to (A) Interfere with synthesis of prostaglandins (B) Decrease the effects of Glucagon (C) Enhance the effects of epinephrine (D) Provide the vitamin nicotinic acid
Description : A cup of strong coffee would be expected to (A) Interfere with the synthesis of prostaglandins (B) Decrease the effect of glucagon (C) Enhance the effect of epinephrine (D) Provide the vitamin nicotinic acid
Description : From arachidonate, synthesis of prostaglandins is catalysed by (A) Cyclooxygenase (B) Lipoxygenase (C) Thromboxane synthase (D) Isomerase
Description : For synthesis of prostaglandins, the essential fatty acids give rise to a fatty acid containing (A) 12 carbon atoms (B) 16 carbon atoms (C) 20 carbon atoms (D) 24 carbon atoms
Description : Thromboxanes cause (A) Vasodilation (B) Bronchoconstriction (C) Platelet aggregation (D) All of these
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate
Description : Synthesis of prostaglandinsis is inhibited by (A) Aspirin (B) Arsenic (C) Fluoride (D) Cyanide
Last Answer : A
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid
Last Answer : B
Description : By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway.
Last Answer : B. It blocks the cyclo-oxygenase pathway.
Description : Methotrexate blocks the synthesis of thymidine monophosphate by inhibiting the activity of the enzyme: (A) Dihydrofolate reductase (B) Orotate phosphoribosyl transferase (C) Ribonucleotide reductase (D) Dihydroorotase
Description : Cyclooxygenase-1 and –2 are responsible for (a) The synthesis of prostaglandins from arachidonate (b) The synthesis of leukotrienes from arachidonate (c) The conversion of ATP to cAMP (d) The metabolic degradation of cAMP (e) The conversion of GTP to cGMP
Last Answer : Ans: A
Description : .Which of these is not an important component of initiation of parturition in humans? (a) Release of oxytocin (b) Release of prolactin (c) Increase in estrogen and progesterone ratio (d) Synthesis of prostaglandins
Last Answer : b) Release of prolactin
Description : Of the following classifications of medications, which is known to inhibit prostaglandin synthesis or release? a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs ... to cause immunosuppression. d) Antineoplastic agents Antineoplastic agents are known to cause immunosuppression.
Last Answer : a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs include aspirin and ibuprofen.
Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors
Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation
Description : Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because: A. Aspirin persists in the body for 5-7 days B. Aspirin induced depletion of arachidonic acid lasts 5-7 ... 5-7 days D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days
Last Answer : D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days
Description : Aspirin prolongs bleeding time by inhibiting the synthesis of: A. Clotting factors in liver B. Prostacyclin in vascular endothelium C. Cyclic AMP in platelets D. Thromboxane A2 in platelets
Last Answer : D. Thromboxane A2 in platelets
Description : The distinctive feature of nimesulide is: A. It does not inhibit prostaglandin synthesis B. It does not cause gastric irritation C. It is usually well tolerated by aspirin intolerant asthma patients D. It is not bound to plasma proteins
Last Answer : C. It is usually well tolerated by aspirin intolerant asthma patients
Description : Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension
Last Answer : A. Pregnancy induced hypertension
Description : Inhibition of prostaglandin synthesis does not underlie the following action of aspirin: A. Analgesia B. Closure of patent ductus arteriosus C. Hyperventilation D. Bleeding tendency
Last Answer : C. Hyperventilation
Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin
Last Answer : A. Thromboxane
Last Answer : (A) Aspirin
Last Answer : (B) Allopurinol
Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time
Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition
Description : The activity of kinins is modulated by (A) Prostaglandins (B) Ca++ (C) Increased cAMP level (D) Increased cGMP level
Description : Which one of the following hormones is derived most completely from tyrosine? (A) Glucagon (B) Thyroxine (C) Insulin (D) Prostaglandins
Description : The suffix number in the names of prostaglandins gives the number of (A) OH groups (B) Double bonds (C) Acid groups (D) Ketoacids
Description : Which of tne of the following scientists has not worked in the field of prostaglandins? (A) Voneuler (B) Sultan Karim (C) Andre robet (D) Kendal
Description : Prostaglandins are (A) C2 unsaturated acids (B) C27 saturated alcohols (C) C20 saturated acids (D) C27 saturated alcohols
Description : Which of the following property of prostaglandins has been utilized by chinicians in hospital for (A) Inducing fever (B) Causing inflammation (C) Effecting smooth muscle contraction (D) Disaggregation of spermatozoa
Description : Richest source of prostaglandins in a human male is (A) Blood (B) Urine (C) Semen (D) C.S.F.
Description : Cholesterol is the precursor for the biosynthesis of (A) fatty acid (B) prostaglandins (C) bile acids (D) sphingmyelin
Description : Acrolein Test is positive for (A) Glycerol (B) Prostaglandins (C) Carbohydrates (D) Proteins
Description : All the following are functions of prostaglandins except (A) Lowering of B.P (B) Introduction of labour (C) Anti inflammatory (D) Prevention of myocardial infraction
Description : Prostaglandins are synthesized in the body from (A) Myristic acid (B) Arachidonic acid (C) Stearic acid (D) Lignoceric acid
Description : All active prostaglandins have atleast one double bond between positions: (A) 7 and 8 (B) 9 and 10 (C) 11 and 12 (D) 13 and 14 FATS AND FATTY ACID METABOLISM 95
Description : Prostaglandins have a common structure based on prostanoic acid which contains carbon atoms: (A) 12 (B) 16 (C) 18 (D) 20
Description : Prostaglandins are liberated in the circulation by the stimulation of (A) Anterior pituitary glands (B) Posterior pituitary glands (C) Adrenal gland (D) Thyroid gland
Description : The prostaglandins are synthesized from (A) Arachidonic acid (B) Oleic acid (C) Linoleic acid (D) Linolenic acid
Description : Prostaglandins decrease all of the following except (A) Gastric acid secretion (B) Blood pressure (C) Uterine contraction (D) Platelet aggregation
Description : Prostaglandins stimulate (A) Aggregation of platelets (B) Lipolysis in adipose tissue (C) Bronchodilatation (D) Gastric acid secretion
Description : Prostaglandins are inactivated by (A) 15-Hydroxyprostaglandin dehydrogenase (B) Cyclo-oxygenase (C) Lipo-oxygenase (D) None of these