Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy
Last Answer : Answer : A
Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria
Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.
Description : Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase
Description : Trials for gene therapy in human beings were first carried out, with considerable success, in a genetic disease called (A) Cystic fibrosis (B) Thalassemia (C) Adenosine deaminase deficiency (D) Lesch-Nyhan syndrome
Last Answer : Answer : C
Description : Lesch-Nyhan syndrome?
Last Answer : DefinitionLesch-Nyhan syndrome is an inheritable disorder that affects how the body builds and breaks down purines. Purines are a normal part of human tissue and help make up the body's genetic blueprint. ... to develop gout-like swelling in some of their joints. In some cases, kidney and bl
Description : All of the following statements about Tangier disease are true except (A) It is a disorder of HDL metabolism (B) Its inheritance is autosomal recessive (C) Apoproteins A-I and A-II are not synthesised (D) Plasma HDL is increased
Last Answer : Answer : D
Description : Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome
Description : All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers
Last Answer : Answer : B
Description : Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas
Last Answer : Answers-1 Familial hypercholesterolaemia is an autosomal dominant condition manifest by increased LDL concentrations (not chylomicrons) due to constitutional abnormalities and reduced numbers of ... are characteristic and the condition is associated with a premature cardiovascular mortality.
Description : Inheritance of primary gout is (A) Autosomal recessive (B) Autosomal dominant (C) X-linked recessive (D) X-linked dominant
Description : Which of the following is a characteristic feature of acute intermittent porphyria? 1) autosomal recessive inheritance 2) excessive faecal protoporphyrin excretion 3) excessive urinary porphobilinigoen between acute attacks 4) hypernatraemia during attacks 5) photosensitivity
Last Answer : Answers-3 Features of acute intermittent porphyria include urinary porphobilinogen excretion raised between attacks, hyponatraemia during an acute attack and autosomal dominant inheritance.
Description : All of the following can occur in LeschNyhan syndrome except (A) Gouty arthritis (B) Uric acid stones (C) Retarted growth (D) Self-mutiliating behaviour
Description : An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase
Description : How is analyzing the inheritance patterns of sickle cell disease through pedigrees allowed scientists to determine that the disease is autosomal recessive?
Last Answer : Feel Free to Answer
Description : What type of inheritance pattern (are the A and B alleles to each other (Autosomal dominant-Regular dominant-recessive relationship, X linked, co-dominant, incomplete dominant)?
Last Answer : Incomplete dominance
Description : In autosomal recessive inheritance: a. the rarer the trait the higher the possibility of marriages within the same family b. most recessive gene defects cause problem through failure to produce functional protein c. both males and females are affected equally severely d. all above
Last Answer : all above
Description : A man and a woman, who do not show any apparent signs of a certain inherited disease, have seven children (2 daughters and 5 sons). Three of the sons suffer from the given disease but none ... ? (a) Sex-linked dominant (b) Sex-linked recessive (c) Sex-limited recessive (d) Autosomal dominant
Last Answer : (b) Sex-linked recessive
Description : Study the pedigree chart given below. What does it show? (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait. (b) The pedigree chart is wrong as this is ... disease like haemophilia. (d) Inheritance of a sex-linked inborn error of metabolism like phenylketonuria
Last Answer : (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait.
Description : Which type of Mendelian inherited condition results in both genders being affected equally in a vertical pattern? a) Automosomal dominant inheritance An individual who has an autosomal dominant ... that combine during early embryonic development leading to incomplete closure of the neural tube.
Last Answer : a) Automosomal dominant inheritance An individual who has an autosomal dominant inherited condition carries a gene mutation for that condition on one chromosome of a pair.
Description : All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease
Description : Pick out the correct statements. (1) Haemophilia is a sex-linked recessive disease. (2) Down's syndrome is due to aneuploidy. (3) Phenylketonuria is an autosomal recessive gene disorder. (4) Sickle cell anaemia is an X- ... are correct. (c) (1) and (4) are correct. (d) (2) and (4) are correct.
Last Answer : (b) (1), (2) and (3) are correct.
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Description : A genetically diseased father (male) marries with a normal female and gives birth to 3 carrier girls and 5 normal sons. It may be which type of genetic disease? (a) Sex-influenced disease (b) Blood group inheritance disease (c) Sex-linked disease (d) Sex-recessive disease
Last Answer : (c) Sex-linked disease
Description : Which one is the incorrect statement with regard to the importance of pedigree analysis? (a) It confirms that DNA is the carrier of genetic information. (b) It helps to understand whether the trait in ... linked to one of the autosome. (d) It helps to trace the inheritance of a specific trait.
Last Answer : (a) It confirms that DNA is the carrier of genetic information.
Description : A true breeding plant is (a) one that is able to breed on its own (b) produced due to cross-pollination among unrelated plants (c) near homozygous and produces offspring of its own kind (d) always homozygous recessive in its genetic constitution.
Last Answer : c) near homozygous and produces offspring of its own kind
Description : Which of the following statement(s) is/are true concerning hemophilia A? a. Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII b. A positive family history for ... platelet aggregation d. Spontaneous bleeding is unusual with factor VIII levels greater than 10% of normal
Last Answer : Answer: a, d Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII although 0% of cases are secondary to spontaneous mutation. The incidence of this abnormality is ... factor levels as low as 1% have been noted and patients are at risk for spontaneous bleeding
Description : Down Syndrome, a congenital genetic disorder in human beings, is cased by : (a) a defective recessive gene in homozygous condition (b) an extra x chromosome (c) trisomy of chromosome 18 (d) trisomy of chromosome 21
Last Answer : Ans:(d)
Description : Non-protein nitrogenous substances in blood include all of the following except (A) Urea (B) Uric acid (C) Creatinine (D) Inositol
Description : Autosomal recessive?
Last Answer : DefinitionAutosomal recessive is one of several ways that a trait, disorder, or disease can be passed down through families.An autosomal recessive disorder means two copies of an abnormal gene must be ... be defective to cause disease. People with only one defective gene in the pair are considered
Description : Albinism is known to be due to an autosomal recessive mutation. The first child of a couple with normal skin pigmentation was an albino. What is the probability that their second child will also be an albino? (a) 50% (b) 75% (c) 100% (d) 25%
Last Answer : (d) 25%
Description : .A diseased man marries a normal woman. They get three daughters and five sons. All the daughters were diseased and sons were normal. The gene of this disease is (a) sex linked dominant (b) sex linked recessive (c) sex limited character (d) autosomal dominant.
Last Answer : (a) sex linked dominant
Description : If both parents are carriers for thalassaemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child? (a) 25% (b) 100% (c) No chance (d) 50%
Last Answer : 25%
Description : n the following human pedigree, the filled symbols represent the affected individuals. Identify the type of given pedigree. (i) (ii) (iii) (iv) (a) Autosomal recessive (b) X-linked dominant (c) Autosomal dominant (d) X-linked recessive
Last Answer : (a) Autosomal recessive
Description : Select the correct match. (a) Haemophilia – Y linked (b) Phenylketonuria – Autosomal dominant trait (c) Sickle cell anaemia – Autosomal recessive trait,chromosome -11 (d) Thalassemia – X linked
Last Answer : (c) Sickle cell anaemia – Autosomal recessive trait,chromosome -11
Description : Ataxia is the term that refers to a) uncoordinated muscle movement. Ataxia-telangiectasia is an autosomal recessive disorder affecting both T-cell and B-cell immunity. b) vascular lesions ... to understand the spoken word. d) difficulty swallowing. Dysphagia refers to difficulty swallowing.
Last Answer : a) uncoordinated muscle movement. Ataxia-telangiectasia is an autosomal recessive disorder affecting both T-cell and B-cell immunity.
Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase
Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males
Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate
Description : All of the following statements about uric acid are true except (A) It is a catabolite of purines (B) It is excreted by the kidneys (C) It is undissociated at pH above 5.8 (D) It is less soluble than sodium urate
Description : Which of the following enzyme typically elevated in alcoholism? (A) Serum ALP (B) Serum GOT (C) Serum γ-GT (D) Serum acid phosphatase
Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased
Description : Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine
Description : What is an autosomal dominant pattern of inheritance?
Last Answer : Need answer
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate
Description : In humans purine are catabolised to uric acid due to lack of the enzyme: (A) Urease (B) Uricase (C) Xanthine oxidase (D) Guanase
Description : Schardinger’s enzyme is (A) Lactate dehydrogenase (B) Xanthine dehydrogenase (C) Uric oxidase (D) L amino acid dehydrogenase
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid
Last Answer : B
Description : All of the following are true of Wilson’s disease except (A) Low total plasma Cu (B) Elevated urinary copper (C) Arthritis (D) Aminoaciduria
Description : Inherited deficiency of enzyme cerebrosidase produces (A) Fabry’s disease (B) Niemann pick disease (C) Gaucher’s disease (D) Tay-sach’s disease