Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible

Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible
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Answer :

B. Platelets cannot synthesize fresh COX molecules
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Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible

Description : Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible

Last Answer : Ans: B

Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin

Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin

Last Answer : A. Thromboxane

Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because: A. Aspirin persists in the body for 5-7 days B. Aspirin induced depletion of arachidonic acid lasts 5-7 days C. Regeneration of aspirin inhibited cyclooxygenase takes 5-7 days D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

Description : Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because: A. Aspirin persists in the body for 5-7 days B. Aspirin induced depletion of arachidonic acid lasts 5-7 ... 5-7 days D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

Last Answer : D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible

Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible

Last Answer : Ans: D

The isoenzyme cyclooxygenase-2 (COX-2) is expressed constitutively at the following site: A. Gastric mucosa B. Neutrophils C. Blood platelets D. Juxtaglomerular apparatus

Description :  The isoenzyme cyclooxygenase-2 (COX-2) is expressed constitutively at the following site: A. Gastric mucosa B. Neutrophils C. Blood platelets D. Juxtaglomerular apparatus

Last Answer : D. Juxtaglomerular apparatus

The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely

Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely

Last Answer : D. COX-1 is constitutive while COX-2 is largely

What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above

Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above

Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition

Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition

The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules C. Phosphorylation results in rapid degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Description : The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind ... degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Last Answer : B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules

The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues

Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues

Last Answer : B. It is inducible

The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen

Description : The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen

Last Answer : B. Meloxicam

The action of aspirin that results in its greater efficacy as an antithrombotic (anti-platelet) drug is its ability to (a) Inhibit lipoxygenase as well as cyclooxygenase (b) Selectively inhibit cyclooxygenase I (c) Inhibit leukocyte migration (d) Promote uric acid excretion (e) Acetylate cyclooxygenase

Description : The action of aspirin that results in its greater efficacy as an antithrombotic (anti-platelet) drug is its ability to (a) Inhibit lipoxygenase as well as cyclooxygenase (b) Selectively inhibit ... I (c) Inhibit leukocyte migration (d) Promote uric acid excretion (e) Acetylate cyclooxygenase

Last Answer : Ans: E

Which of the following is a reversible inhibitor of platelet cyclooxygenase? (a) Alprostadil (b) Aspirin (c) Ibuprofen (d) LTC4 (e) Misoprostol

Description : Which of the following is a reversible inhibitor of platelet cyclooxygenase? (a) Alprostadil (b) Aspirin (c) Ibuprofen (d) LTC4 (e) Misoprostol

Last Answer : Ans: C

A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. Synthesis of prostacyclin and prevents platelet aggregation C. Synthesis of prostaglandin and prevents production of blood platelets D. Thrombin and prevents formation of the fibrin network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation

Laboratory monitoring of coagulation and anticoagulation includes testing of platelet function. Which of the following statements is/are true concerning tests of platelet function? a. A platelet count of 50,000/µL or more usually ensures hemostasis b. Bleeding time assays assessibility of platelets to perform hemostatic plugs and is determined from a sample of blood drawn in an EDTA coated test tube c. Aspirin therapy can be associated with a bleeding time in the range of 8–15 minutes d. Tests of platelet aggregation should be part of the standard preoperative evaluation of patients using aspirin

Description : Laboratory monitoring of coagulation and anticoagulation includes testing of platelet function. Which of the following statements is/are true concerning tests of platelet function? a. A ... platelet aggregation should be part of the standard preoperative evaluation of patients using aspirin

Last Answer : Answer: a, c Tests of platelet function include peripheral platelet counts, bleeding times, and platelet aggregation. Usually, a platelet count of 50,000/mL or more ensures adequate hemostasis ... is not available in most laboratories, probably because of the observer-dependent nature of the test

Which of the following is seen at low (analgesic) doses of aspirin: A. Respiratory stimulation B. Increased occult blood loss in stools C. Increased cardiac output D. Hyperglycaemia

Description :  Which of the following is seen at low (analgesic) doses of aspirin: A. Respiratory stimulation B. Increased occult blood loss in stools C. Increased cardiac output D. Hyperglycaemia

Last Answer : B. Increased occult blood loss in stools

The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation C. Heparin is the physiologically active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Last Answer : C. Heparin is the physiologically active circulating anticoagulant

Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam

Description : Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam

Last Answer : A. Aspirin

Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells C. Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Last Answer : D. All of the above

Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension

Description : Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension

Last Answer : A. Pregnancy induced hypertension

Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. Used alone, its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop

Description : Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. ... its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop

Last Answer : C. Used alone, its effective doses produce intolerable side effect

Which of the following statements concerning platelets is INCORRECT. Platelets: a) contain DNA b) are roughly disk-shaped c) have little ability to synthesize proteins d) are between 1/2 and 1/3 the diameter of the red cell

Description : Which of the following statements concerning platelets is INCORRECT. Platelets: a) contain DNA b) are roughly disk-shaped c) have little ability to synthesize proteins d) are between 1/2 and 1/3 the diameter of the red cell

Last Answer : ANSWER: A -- contain DNA

The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules C. Phosphorylation results in rapid degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Description : The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind ... degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Last Answer : B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules

Oxethazaine is used for anaesthetizing gastric mucosa because: A. It is not absorbed from the gastrointestinal tract B. It remains largely unionized in acidic medium C. It is highly ionized in acidic medium D. It produces no systemic effects even at high doses

Description : Oxethazaine is used for anaesthetizing gastric mucosa because: A. It is not absorbed from the gastrointestinal tract B. It remains largely unionized in acidic medium C. It is highly ionized in acidic medium D. It produces no systemic effects even at high doses

Last Answer : B. It remains largely unionized in acidic medium

Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin

Description : Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin

Last Answer : B. Ticlopidine

The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab

Description : The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab

Last Answer : C. Dipyridamole

Aspirin prolongs bleeding time by inhibiting the synthesis of: A. Clotting factors in liver B. Prostacyclin in vascular endothelium C. Cyclic AMP in platelets D. Thromboxane A2 in platelets

Description : Aspirin prolongs bleeding time by inhibiting the synthesis of: A. Clotting factors in liver B. Prostacyclin in vascular endothelium C. Cyclic AMP in platelets D. Thromboxane A2 in platelets

Last Answer : D. Thromboxane A2 in platelets

Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism

Description : Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism

Last Answer : C. In equianalgesic doses it is safer than aspirin

The plasma half life of aspirin (along with salicylic acid released from it): A. Remains constant irrespective of dose B. Is longer for antiinflammatory doses compared to that for analgesic dose C. Is shorter for antiinflammatory doses compared to that for analgesic dose D. Can be shortened by acidifying urine

Description : The plasma half life of aspirin (along with salicylic acid released from it): A. Remains constant irrespective of dose B. Is longer for antiinflammatory doses compared to that for analgesic ... for antiinflammatory doses compared to that for analgesic dose D. Can be shortened by acidifying urine

Last Answer : B. Is longer for antiinflammatory doses compared to that for analgesic dose

Metabolic effects that generally attend antiinflammatory doses of aspirin include the following except: A. Increased CO2 production B. Hepatic glycogen depletion C. Metabolic acidosis D. Compensated respiratory alkalosis

Description : Metabolic effects that generally attend antiinflammatory doses of aspirin include the following except: A. Increased CO2 production B. Hepatic glycogen depletion C. Metabolic acidosis D. Compensated respiratory alkalosis

Last Answer : C. Metabolic acidosis

The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Last Answer : Ans: B

.Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition because excess of β-galactosidase can switch off transcription (c) positive and inducible because it can be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Description : .Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition ... be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Last Answer : (d) negative and inducible because repressor protein prevents transcription.

Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition because excess of β-galactosidase can switch off transcription (c) positive and inducible because it can be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Description : Gene regulation governing lactose operon of E.coli that involves the lac I gene product is (a) negative and repressible because repressor protein prevents transcription (b) feedback inhibition ... be induced by lactose (d) negative and inducible because repressor protein prevents transcription.

Last Answer : (d) negative and inducible because repressor protein prevents transcription.

Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme C. It inhibits bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above

Description : Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate ... bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above

Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme

The following is true of pethidine except: A. At equianalgesic doses it causes less respiratory depression than morphine B. It is less constipating than morphine C. It is a poor antitussive D. In overdose it often produces excitatory effect

Description : The following is true of pethidine except: A. At equianalgesic doses it causes less respiratory depression than morphine B. It is less constipating than morphine C. It is a poor antitussive D. In overdose it often produces excitatory effect

Last Answer : A. At equianalgesic doses it causes less respiratory depression than morph

Hydralazine is a directly acting vasodilator, but is not used alone as an antihypertensive because: A. By itself, it is a low efficacy antihypertensive B. Effective doses cause marked postural hypotension C. Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms D. It primarily reduces systolic blood pressure with little effect on diastolic blood pressure

Description : Hydralazine is a directly acting vasodilator, but is not used alone as an antihypertensive because: A. By itself, it is a low efficacy antihypertensive B. Effective doses cause marked ... mechanisms D. It primarily reduces systolic blood pressure with little effect on diastolic blood pressure

Last Answer : C. Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms

Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out tetracyclines C. Protein synthesizing apparatus of host cells has low affinity for tetracyclines D. Both ‘A’ and ‘C’ are correct

Description : Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out ... host cells has low affinity for tetracyclines D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

Methicillin resistant staphylococci do not respond to β-lactam antibiotics because: A. They produce a β-lactamase which destroys methicillin and related drugs B. They elaborate an amidase which destroys methicillin and related drugs C. They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics D. They are less permeable to β-lactam antibiotics

Description : Methicillin resistant staphylococci do not respond to β-lactam antibiotics because: A. They produce a β-lactamase which destroys methicillin and related drugs B. They elaborate an amidase which destroys ... low affinity for β-lactam antibiotics D. They are less permeable to β-lactam antibiotics

Last Answer : C. They have acquired penicillin binding protein which has low affinity for β-lactam antibioti

Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation

Description :  Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation

Last Answer : D. Do not inhibit platelet aggregation

Choose the correct statement about aspirin: A. In an afebrile patient acute overdose of aspirin produces hypothermia B. Aspirin suppresses flushing attending large dose of nicotinic acid C. Aspirin therapy prevents granulomatous lesions and cardiac complications of acute rheumatic fever D. Long term aspirin therapy increases the risk of developing colon cancer

Description : Choose the correct statement about aspirin: A. In an afebrile patient acute overdose of aspirin produces hypothermia B. Aspirin suppresses flushing attending large dose of nicotinic acid C. Aspirin ... acute rheumatic fever D. Long term aspirin therapy increases the risk of developing colon cancer

Last Answer : B. Aspirin suppresses flushing attending large dose of nicotinic acid

Mini-dose heparin has been shown to be useful in the prophylaxis of postoperative venous thrombosis. Mechanism(s) by which low-dose heparin is/are thought to protect against venous thrombosis include: a. Enhancement of antithrombin III activity b. A decrease in thrombin availability c. Inhibition of platelet aggregation and subsequent platelet release action d. A mild prolongation of activated partial thromboplastin time

Description : Mini-dose heparin has been shown to be useful in the prophylaxis of postoperative venous thrombosis. Mechanism(s) by which low-dose heparin is/are thought to protect against venous ... aggregation and subsequent platelet release action d. A mild prolongation of activated partial thromboplastin time

Last Answer : Answer: a, b, c Low-dose heparin is thought to protect against venous thrombosis through three different mechanisms. First, antithrombin III activity with its inhibition of activated Factor X is ... release reaction. The standard doses of heparin administered (5000 units bid) does not affect aPTT

Choose the correct statement about pentazocine: A. It causes bradycardia and fall in blood pressure B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses C. It induces vomiting frequently D. It substitutes for morphine in dependent subjects

Description : Choose the correct statement about pentazocine: A. It causes bradycardia and fall in blood pressure B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses C. It induces vomiting frequently D. It substitutes for morphine in dependent subjects

Last Answer : B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses

A man has an Escherichia coli bacteremia with a low-grade fever (101.6°F). Appropriate management of his fever would be (a) Give acetaminophen 650 mg orally every 4 hours (b) Give aspirin 650 mg orally every 4 hours (c) Give alternating doses of aspirin and acetaminophen every 4 hours (d) Withhold antipyretics, and use the fever curve to monitor his response to antibiotic therapy (e) Use tepid water baths to reduce the fever

Description : A man has an Escherichia coli bacteremia with a low-grade fever (101.6°F). Appropriate management of his fever would be (a) Give acetaminophen 650 mg orally every 4 hours (b) Give aspirin 650 ... fever curve to monitor his response to antibiotic therapy (e) Use tepid water baths to reduce the fever

Last Answer : Ans: D

Non steroidal anti inflammatory drugs, such as aspirin act by inhibiting the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipase A2 (D) Lipoprotein lipase

Description : Non steroidal anti inflammatory drugs, such as aspirin act by inhibiting the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipase A2 (D) Lipoprotein lipase

Last Answer : Answer : B

Aspirin inhibits the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipae A1 (D) Phospholipase A2

Description : Aspirin inhibits the activity of the enzyme: (A) Lipoxygenase (B) Cyclooxygenase (C) Phospholipae A1 (D) Phospholipase A2

Last Answer : Answer : B

Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Last Answer : Ans: A

Aspirin may reduce inflammatory responses by inhibiting which of the following enzymes? A A. Cyclooxygenase B. Lipoxygenase C. Phospholipase C D. None of these

Description : Aspirin may reduce inflammatory responses by inhibiting which of the following enzymes? A A. Cyclooxygenase B. Lipoxygenase C. Phospholipase C D. None of these

Last Answer : Cyclooxygenase

Select the drug which inhibits cyclooxygenase irreversibly: A. Aspirin B. Mephenamic acid C. Naproxen D. Diclofenac

Description : Select the drug which inhibits cyclooxygenase irreversibly: A. Aspirin B. Mephenamic acid C. Naproxen D. Diclofenac

Last Answer : A. Aspirin

Acquisition of inducible energy dependent efflux proteins by bacteria serves to: A. Secrete exotoxins B. Enhance virulance C. Lyse host tissue D. Confer antibiotic resistance

Description : Acquisition of inducible energy dependent efflux proteins by bacteria serves to: A. Secrete exotoxins B. Enhance virulance C. Lyse host tissue D. Confer antibiotic resistance

Last Answer : D. Confer antibiotic resistance

Metronidazole is selectively active against anaerobic organisms because: A. Aerobes have an active transport mechanism to pump it out of their cell B. Only anaerobes reduce it to generate the reactive nitro radical C. It is rapidly inactivated in the presence of oxygen D. It binds to DNA of anaerobes with high affinity

Description : Metronidazole is selectively active against anaerobic organisms because: A. Aerobes have an active transport mechanism to pump it out of their cell B. Only anaerobes reduce it to generate the reactive ... inactivated in the presence of oxygen D. It binds to DNA of anaerobes with high affinity

Last Answer : B. Only anaerobes reduce it to generate the reactive nitro radical