The most commonly occurring conjugation reaction for drugs and their metabolites is: A. Glucuronidation B. Acetylation C. Methylation D. Glutathione conjugation

The most commonly occurring conjugation reaction for
drugs and their metabolites is:
A. Glucuronidation
B. Acetylation
C. Methylation
D. Glutathione conjugation
by

1 Answer

Answer :

A. Glucuronidation
by

Related questions

The most commonly occurring conjugation reaction for drugs and their metabolites is: A. Glucuronidation B. Acetylation C. Methylation D. Glutathione conjugation

Description : The most commonly occurring conjugation reaction for drugs and their metabolites is: A. Glucuronidation B. Acetylation C. Methylation D. Glutathione conjugation

Last Answer : A. Glucuronidation

The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction

Description : The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction

Last Answer : B. Acetylation

The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction

Description : The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction

Last Answer : B. Acetylation

Drug called ‘Heroin’ is synthesised by (a) nitration of morphine (b) methylation of morphine (c) acetylation of morphine (d) glycosylation of morphine.

Description : Drug called ‘Heroin’ is synthesised by (a) nitration of morphine (b) methylation of morphine (c) acetylation of morphine (d) glycosylation of morphine.

Last Answer : (c) acetylation of morphine

Menadione (vitamin K3) can produce kernicterus in neonates by: A. Inducing haemolysis B. Inhibiting glucuronidation of bilirubin C. Displacing plasma protein bound bilirubin D. Both ‘A’ and ‘B’ are correct

Description : Menadione (vitamin K3) can produce kernicterus in neonates by: A. Inducing haemolysis B. Inhibiting glucuronidation of bilirubin C. Displacing plasma protein bound bilirubin D. Both ‘A’ and ‘B’ are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

Removal of BSP dye by the liver involves conjugation with (A) Thiosulphate (B) Glutamine (C) Cystein component of glutathione (D) UDP glucuronate

Description : Removal of BSP dye by the liver involves conjugation with (A) Thiosulphate (B) Glutamine (C) Cystein component of glutathione (D) UDP glucuronate

Last Answer : Answer : C

The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation C. They may exert bactericidal action in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections

Description : The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation ... in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections

Last Answer : A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble

The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of dopamine methylation in the brain C. Inhibition of oxidative deamination of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

Description : The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of ... of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

Last Answer : A. Inhibition of levodopa methylation in the liver

The principal process which terminates the action of noradrenaline released from adrenergic nerve ending is: A. Degradation by MAO B. Methylation by COMT C. Axonal uptake D. Extraneuronal uptake

Description : The principal process which terminates the action of noradrenaline released from adrenergic nerve ending is: A. Degradation by MAO B. Methylation by COMT C. Axonal uptake D. Extraneuronal uptake

Last Answer : C. Axonal uptake

N-acetyl cysteine is beneficial in acute paracetamol poisoning because: A. It reacts with paracetamol to form a nontoxic complex B. It inhibits generation of the toxic metabolite of paracetamol C. It is a free radical scavenger D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

Description : N-acetyl cysteine is beneficial in acute paracetamol poisoning because: A. It reacts with paracetamol to form a nontoxic complex B. It inhibits generation of the toxic metabolite of ... scavenger D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

Last Answer : D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

What is NOT TRUE in relation to the prescription of 5mg or 10mg of diazepam for sedation?check A. Patient commonly complain of post operative headache T B. An acceptable level of anxiolytic action is obtained when the drug is given one hour preoperatively T C. There is a profound amnesic action and no side affects not sure D. Active metabolites can give a level of sedation up to 8 hours post operatively T E. As Benzodiazepine the action can be reversed with FlumazepilNE T

Description : What is NOT TRUE in relation to the prescription of 5mg or 10mg of diazepam for sedation?check A. Patient commonly complain of post operative headache T B. An acceptable level of anxiolytic ... to 8 hours post operatively T E. As Benzodiazepine the action can be reversed with FlumazepilNE T

Last Answer : C. There is a profound amnesic action and no side affects not sure

Penicillins interfere with bacterial cell wall synthesis by: A. Inhibiting synthesis of N-acetyl muramic acid pentapeptide B. Inhibiting conjugation between N-acetyl muramic acid and N-acetyl glucosamine C. Inhibiting transpeptidases and carboxypeptidases which cross link the peptidoglycan residues D. Counterfeiting for D-alanine in the bacterial cell wall

Description : Penicillins interfere with bacterial cell wall synthesis by: A. Inhibiting synthesis of N-acetyl muramic acid pentapeptide B. Inhibiting conjugation between N-acetyl muramic acid and N-acetyl ... cross link the peptidoglycan residues D. Counterfeiting for D-alanine in the bacterial cell wall

Last Answer : C. Inhibiting transpeptidases and carboxypeptidases which cross link the peptidoglycan residues

The most important mechanism of concurrent acquisition of multidrug resistance among bacteria is: A. Mutation B. Conjugation C. Transduction D. Transformation

Description : The most important mechanism of concurrent acquisition of multidrug resistance among bacteria is: A. Mutation B. Conjugation C. Transduction D. Transformation

Last Answer : B. Conjugation

Widespread and prolonged use of an antibiotic leads to emergence of drug resistant strains because antibiotics: A. Induce mutation in the bacteria B. Promote conjugation among bacteria C. Allow resistant strains to propagate preferentially D. All of the above

Description : Widespread and prolonged use of an antibiotic leads to emergence of drug resistant strains because antibiotics: A. Induce mutation in the bacteria B. Promote conjugation among bacteria C. Allow resistant strains to propagate preferentially D. All of the above

Last Answer : C. Allow resistant strains to propagate preferentially

Vitamin K is indicated for the treatment of bleeding occurring in patients: A. Being treated with heparin B. Being treated with streptokinase C. Of obstructive jaundice D. Of peptic ulcer

Description : Vitamin K is indicated for the treatment of bleeding occurring in patients: A. Being treated with heparin B. Being treated with streptokinase C. Of obstructive jaundice D. Of peptic ulcer

Last Answer : C. Of obstructive jaundice

What is true of tolerance occurring in regular opium abusers: A. Tolerance develops to all actions of morphine B. No tolerance occurs to euphoric and sedative actions of morphine C. No tolerance occurs to constipating and miotic actions of morphine D. Lethal dose of morphine is not significantly increased

Description : What is true of tolerance occurring in regular opium abusers: A. Tolerance develops to all actions of morphine B. No tolerance occurs to euphoric and sedative actions of morphine C. No ... to constipating and miotic actions of morphine D. Lethal dose of morphine is not significantly increased

Last Answer : C. No tolerance occurs to constipating and miotic actions of morphine

Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin: A. Blocks the increased risk of myocardial infarction due to estrogen B. Blocks the increased risk of endometrial carcinoma due to estrogen C. Reverses vulval atrophy occurring in postmenopausal women D. Enhances the metabolic benefits of estrogen treatment

Description : Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin: A. Blocks the increased risk of myocardial ... vulval atrophy occurring in postmenopausal women D. Enhances the metabolic benefits of estrogen treatment

Last Answer : The estrogen commonly used for hormone replacement therapy in menopausal women is: A. Ethinylestradiol B. Estradiol benzoate C. Diethylstilbestrol D. Conjugated estrogens

Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) Cyclooxygenase 1 (b) Cyclooxygenase 2 (c) Glutathione – S – transferase (d) Lipoxygenase (e) Phospholipase A2

Description : Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by (a) ... 2 (c) Glutathione - S - transferase (d) Lipoxygenase (e) Phospholipase A2

Last Answer : Ans: B

Which one of the following organisms is scientifically correctly named, correctly printed according to the International Rules of Nomenclature and correctly described? (a) Musca domestica - the common house lizard, a reptile (b) Plasmodium falciparum - a protozoan pathogen causing the most serious type of malaria. (c) Felis tigris - the Indian tiger, well protected in Gir forests. (d) E.coli - full name Entamoeba coli, a commonly occurring bacterium in human intestine.

Description : Which one of the following organisms is scientifically correctly named, correctly printed according to the International Rules of Nomenclature and correctly described? (a) Musca domestica - the common ... ) E.coli - full name Entamoeba coli, a commonly occurring bacterium in human intestine.

Last Answer : (b) Plasmodium falciparum - a protozoan pathogen causing the most serious type of malaria

In the case of malignant melanoma occurring intra orally, which of the following is true: a. Uncommon on the palate when occurs intra orally. b. Should not biopsied, as this will increase metasis . c. The 5 year survival rate is 20%. d. The incidence of oral melanoma is the same as those on the skin. e. Commonly occurs intra orally.

Description : In the case of malignant melanoma occurring intra orally, which of the following is true: a. Uncommon on the palate when occurs intra orally. b. Should not biopsied, as this will increase metasis ... incidence of oral melanoma is the same as those on the skin. e. Commonly occurs intra orally.

Last Answer : c. The 5 year survival rate is 20%.

In the case of malignant melanoma occurring intra orally, which of the following is true: A. Uncommon on the palate when occurs intra orally B. Should not biopsied, as this will increase metasis C. The 5 years survival rate is 20% D. The incidence of oral melanoma is the same as those on the skin E. Commonly occurs intra orally

Description : In the case of malignant melanoma occurring intra orally, which of the following is true: A. Uncommon on the palate when occurs intra orally B. Should not biopsied, as this will increase metasis ... The incidence of oral melanoma is the same as those on the skin E. Commonly occurs intra orally

Last Answer : C. The 5 years survival rate is 20%

Leishmania donovani is susceptible to certain antifungal drugs because both fungi and Leishmania: A. Utilise purine salvage pathway B. Utilise similar glycolytic mechanisms C. Have similar topoisomerase II enzyme D. Have ergosterol in their cell membranes

Description : Leishmania donovani is susceptible to certain antifungal drugs because both fungi and Leishmania: A. Utilise purine salvage pathway B. Utilise similar glycolytic mechanisms C. Have similar topoisomerase II enzyme D. Have ergosterol in their cell membranes

Last Answer : D. Have ergosterol in their cell membranes

The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit

Description : The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit

Last Answer : B. Their prolonged use can cause atrophy of gastric mucosa

The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory increase in reabsorption at sites not affected by these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve

Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve

Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action

Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs C. They do not worsen blood lipid profile D. They do not impair work performance

Description : Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal ... . They do not worsen blood lipid profile D. They do not impair work performance

Last Answer : B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs

The nonselective MAO inhibitors are not used clinically as antidepressants because of their: A. Low antidepressant efficacy B. Higher toxicity C. Potential to interact with many foods and drugs D. Both 'B' and 'C' are correct

Description : The nonselective MAO inhibitors are not used clinically as antidepressants because of their: A. Low antidepressant efficacy B. Higher toxicity C. Potential to interact with many foods and drugs D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone

Description : The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone

Last Answer : A. Baclofen

Sodium phenoxide when heated with `CO_(2)` under pressure at `125^(@) C` yield a product which on acetylation gives product `C`

Description : Sodium phenoxide when heated with `CO_(2)` under pressure at `125^(@) C` yield a product which on acetylation gives product `C`

Last Answer : Sodium phenoxide when heated with `CO_(2)` under pressure at `125^(@) C` yield a product which on acetylation gives product `C` A. B. C. D.

Sodium phenoxide when heated with `CO_(2)` under pressure at `125^(@) C` yield a product which on acetylation gives product `C`

Description : Sodium phenoxide when heated with `CO_(2)` under pressure at `125^(@) C` yield a product which on acetylation gives product `C`

Last Answer : Sodium phenoxide when heated with `CO_(2)` under pressure at `125^(@) C` yield a ... B. salicyladehyde C. sodium benzoate D. sodium salicylate

Pantothenic acid is a constituent of coenzyme involved in (A) Acetylation (B) Decarboxylation (C) Dehydrogenation (D) Oxidation

Description : Pantothenic acid is a constituent of coenzyme involved in (A) Acetylation (B) Decarboxylation (C) Dehydrogenation (D) Oxidation

Last Answer : Answer : A

Pantothenic acid is a constituent of the coenzyme involved in (A) Decarboxylation (B) Dehydrogenation (C) Acetylation (D) Oxidation

Description : Pantothenic acid is a constituent of the coenzyme involved in (A) Decarboxylation (B) Dehydrogenation (C) Acetylation (D) Oxidation

Last Answer : Answer : C

Which of the following is not true of sulfonamides ? (a) They are primarily metabolized by acetylation (b) They are more likely to produce crystalluria in alkaline urine in which they are less soluble (c) They may exert bactericidal action in the urinary tract (d) Used alone, they have become therapeutically unreliable for serious infections

Description : Which of the following is not true of sulfonamides ? (a) They are primarily metabolized by acetylation (b) They are more likely to produce crystalluria in alkaline urine in which they are ... in the urinary tract (d) Used alone, they have become therapeutically unreliable for serious infections

Last Answer : Ans: B

Can tertiary amines undergo acetylation reactions ? Explain.

Description : Can tertiary amines undergo acetylation reactions ? Explain. 

Last Answer : For an amine to undergo acetylation, it should have a replaceable hydrogen atom. Tertiary amines cannot undergo acetylation reactions because these do not have replaceable hydrogen atom.

Basic-hydrolysis of esters is called (a) Acetylation (b) Acidification (c) Esterification (d) Saponification

Description : Basic-hydrolysis of esters is called (a) Acetylation (b) Acidification (c) Esterification (d) Saponification

Last Answer : Saponification

Pantothenic acid is a constituent of the coenzyme involved in (A) Decarboxylation (B) Dehydrogenation (C) Acetylation (D) Oxidation

Description : Pantothenic acid is a constituent of the coenzyme involved in (A) Decarboxylation (B) Dehydrogenation (C) Acetylation (D) Oxidation

Last Answer : (C) Acetylation

The principal rate limiting step in the biosynthesis of bile acids is at the (A) 7-Hydroxylase reaction (B) 12 α-Hydroxylase reaction (C) Conjugation reaction (D) Deconjugation reaction

Description : The principal rate limiting step in the biosynthesis of bile acids is at the (A) 7-Hydroxylase reaction (B) 12 α-Hydroxylase reaction (C) Conjugation reaction (D) Deconjugation reaction

Last Answer : Answer : A

Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): A. To enhance antitumour activity of the drug B. To prevent hypersensitivity reactions to the drug C. To hasten recovery from drug induced myelosuppression D. Both ‘A’ and ‘C’ are correct

Description : Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): A. To enhance antitumour activity of the drug B. To prevent hypersensitivity reactions to ... . To hasten recovery from drug induced myelosuppression D. Both A' and C' are correct

Last Answer : C. To hasten recovery from drug induced myelosuppressio

The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated doses C. The same regimen which is palliative for a large solid tumour may be curative after surgical removal of the tumour D. Combination regimens using several drugs in succession are superior to single drug used continuously

Description : The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated ... D. Combination regimens using several drugs in succession are superior to single drug used continuously

Last Answer : A. Each treatment with a cytotoxic drug kills a constant number of malignant cells

Practically all antineoplastic drugs can produce the following toxic effects except: A. Depression of leucocyte count B. Mucositis C. Cardiomyopathy D. Oligozoospermia

Description : Practically all antineoplastic drugs can produce the following toxic effects except: A. Depression of leucocyte count B. Mucositis C. Cardiomyopathy D. Oligozoospermia

Last Answer : C. Cardiomyopathy

Anticancer drugs weaken host defence by: A. Damaging respiratory and gut epithelia B. Inducing granulocytopenia C. Altering resident microbial flora D. Both 'A' and 'B' are correct

Description : Anticancer drugs weaken host defence by: A. Damaging respiratory and gut epithelia B. Inducing granulocytopenia C. Altering resident microbial flora D. Both 'A' and 'B' are correct

Last Answer : D. Both 'A' and 'B' are correct

The following is true of cancer chemotherapy: A. Anticancer drugs increase the risk of developing leukaemias and lymphomas several years later B. All anticancer drugs are highly emetogenic C. Growth fraction of cancers is higher than any nomral tissue of the body Aim4aiims.in D. All of the above are correct

Description : The following is true of cancer chemotherapy: A. Anticancer drugs increase the risk of developing leukaemias and lymphomas several years later B. All anticancer drugs are highly emetogenic C. Growth fraction of ... than any nomral tissue of the body Aim4aiims.in D. All of the above are correct

Last Answer : A. Anticancer drugs increase the risk of developing leukaemias and lymphomas several years later

Drug/drugs effective in filariasis include: A. Ivermectin B. Albendazole C. Diethyl carbamazine citrate D. All of the above

Description : Drug/drugs effective in filariasis include: A. Ivermectin B. Albendazole C. Diethyl carbamazine citrate D. All of the above

Last Answer : D. All of the above

Chloroquine resistant P. falciparum malaria can be cured by the following drugs except: A. Quinine B. Pyrimethamine + sulfadoxine C. Primaquine D. Artesunate

Description : Chloroquine resistant P. falciparum malaria can be cured by the following drugs except: A. Quinine B. Pyrimethamine + sulfadoxine C. Primaquine D. Artesunate

Last Answer : C. Primaquine

Erythrocytic schizontocide antimalarial drugs are used as: A. Suppressive prophylactic B. Clinical curative C. Radical curative for P.vivax D. Both ‘A’ and ‘B’

Description : Erythrocytic schizontocide antimalarial drugs are used as: A. Suppressive prophylactic B. Clinical curative C. Radical curative for P.vivax D. Both ‘A’ and ‘B’

Last Answer : D. Both ‘A’ and ‘B’

The HIV titer of an AIDS patient was found to be reduced but still detectable after 6 months of tripple drug anti-HIV therapy. The best course of action in this patient is: A. Continue the same 3 drugs for another 3 months B. Replace all 3 drugs with a set of another 3 drugs C. Replace 2 drugs and continue one previously used drug D. Replace one drug and continue two previously used drugs

Description : The HIV titer of an AIDS patient was found to be reduced but still detectable after 6 months of tripple drug anti-HIV therapy. The best course of action in this patient is: A. Continue the ... 2 drugs and continue one previously used drug D. Replace one drug and continue two previously used drugs

Last Answer : B. Replace all 3 drugs with a set of another 3 drugs

An AIDS patient treated with zidovudine + lamivudine + nelfinavir developed intolerable adverse effects. Then: A. Dose of all three drugs should be reduced to half B. All three drugs should be stopped or substituted simultaneously C. The drugs should be stopped one by one D. Two drugs sh

Description : An AIDS patient treated with zidovudine + lamivudine + nelfinavir developed intolerable adverse effects. Then: A. Dose of all three drugs should be reduced to half B. All three drugs should be stopped or substituted simultaneously C. The drugs should be stopped one by one D. Two drugs sh

Last Answer : B. All three drugs should be stopped or substituted simultaneously