Description : The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction
Last Answer : B. Acetylation
Description : The most commonly occurring conjugation reaction for drugs and their metabolites is: A. Glucuronidation B. Acetylation C. Methylation D. Glutathione conjugation
Last Answer : A. Glucuronidation
Description : Which of the following types of drug metabolizing enzymes are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes
Last Answer : A. Microsomal enzymes
Description : Select the antibiotic which inhibits drug metabolizing isoenzyme CYP3A4 resulting in potentially fatal drug interaction with terfenadine: A. Erythromycin B. Clindamycin C. Gentamicin D. Vancomycin
Last Answer : A. Erythromycin
Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed
Last Answer : D. Tubular transport mechanisms are not well developed
Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling
Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine
Description : Widespread and prolonged use of an antibiotic leads to emergence of drug resistant strains because antibiotics: A. Induce mutation in the bacteria B. Promote conjugation among bacteria C. Allow resistant strains to propagate preferentially D. All of the above
Last Answer : C. Allow resistant strains to propagate preferentially
Description : The activity of tocopherols is destroyed by (A) Oxidation (B) Reduction (C) Conjugation (D) All of these
Last Answer : Answer : A
Description : Biluveridin is converted to bilirubin by the process of (A) Oxidation (B) Reduction (C) Conjugation (D) Decarboxylation
Last Answer : Answer : B
Description : The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation ... in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections
Last Answer : A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble
Description : Pantothenic acid is a constituent of coenzyme involved in (A) Acetylation (B) Decarboxylation (C) Dehydrogenation (D) Oxidation
Description : Pantothenic acid is a constituent of the coenzyme involved in (A) Decarboxylation (B) Dehydrogenation (C) Acetylation (D) Oxidation
Last Answer : Answer : C
Last Answer : (C) Acetylation
Description : Penicillins interfere with bacterial cell wall synthesis by: A. Inhibiting synthesis of N-acetyl muramic acid pentapeptide B. Inhibiting conjugation between N-acetyl muramic acid and N-acetyl ... cross link the peptidoglycan residues D. Counterfeiting for D-alanine in the bacterial cell wall
Last Answer : C. Inhibiting transpeptidases and carboxypeptidases which cross link the peptidoglycan residues
Description : The most important mechanism of concurrent acquisition of multidrug resistance among bacteria is: A. Mutation B. Conjugation C. Transduction D. Transformation
Last Answer : B. Conjugation
Description : Drug called ‘Heroin’ is synthesised by (a) nitration of morphine (b) methylation of morphine (c) acetylation of morphine (d) glycosylation of morphine.
Last Answer : (c) acetylation of morphine
Description : The plasma half life of pencillin-G is longer in the new born because their (a) Plasma protein level is low (b) Drug metabolizing enzymes are immature (c) Glomerular filtration rate is low (d) Tubular transport mechanisms are not well developed
Last Answer : Ans: D
Description : Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes? (a) Ciprofloxacin (b) Cyclosporine (c) Erythromycin (d) Rifampin (e) Tetracycline
Description : Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b ... not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci
Last Answer : Ans: C
Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high
Last Answer : C. Tubular transport mechanisms are not well developed
Description : Induction of drug metabolizing enzymes involves: A. A conformational change in the enzyme protein to favour binding of substrate molecules B. Expression of enzyme molecules on the surface of ... C. Enhanced transport of substrate molecules into hepatocytes D. Increased synthesis of enzyme protein
Last Answer : D. Increased synthesis of enzyme protein
Description : Select the hypolipidemic drug that enhances lipoprotein synthesis, fatty acid oxidation and LDLreceptor expression in liver through paroxisome proliferator-activated receptor α: A. Lovastatin B. Atorvastatin C. Bezafibrate D. Nicotinic acid
Last Answer : C. Bezafibrate
Description : Megaloblastic anaemia developing under the following condition is due entirely to folate deficiency not associated with vitamin B12 deficiency: A. Malnutrition B. Blind loop syndrome C. Phenytoin therapy D. Pregnancy
Last Answer : C. Phenytoin therapy
Description : The activity of tocopherols is destroyed by (A) Commercial cooking (B) Reduction (C) Conjugation (D) All of these
Description : Bacteria lack alternation of generation because there is (a) neither syngamy nor reduction division (b) distinct chromosomes are absent (c) no conjugation (d) no exchange of genetic materia
Last Answer : (a) neither syngamy nor reduction division
Description : An enzymatic beta-oxidation process a). Conjugation b). Reverse metabolism c). Translocation d). Metabolism
Last Answer : b). Reverse metabolism
Description : 1. What is the range of Prithvi III, the naval version of Prithvi ? 2. What is the oxidation number and covalency-of sulphur in S8? 3. What is the life of RBC in human blood? 4. ... What is the approximate diameter of the earth? 20. Which is the source of information about early Vedic period?
Last Answer : Answer : 1. 250 km-300 km 2. 0, 2 3. 120 days 4. Chlorofluorocarbons 5. Tai Tsung 6. Consolidated Fund of India 7. Increase in prices 8. Trishul 9. Ecotone 10. Anantvarman 11. Real, inverted and magnified ... dark plain on the moon 15. Lion 16. May 1 17. Money 18. Poison 19. 12,800 Km 20. Rigveda
Description : Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics (a) Induce mutation in the bacteria (b) Promote conjugation among bacteria (c) Allow resistant strains to propagate preferentially (d) All of the above
Description : Which of the following is the cause for drug resistance in tuberculosis? A- Mutation B- Transduction C- Transformation D- Conjugation
Last Answer : Mutation
Description : Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol: A. Dacarbazine B. Procarbazine C. Melphalan D. Hydroxyurea
Last Answer : B. Procarbazine
Description : Select the drug which is a causal prophylactic for both falciparum and vivax malaria but is not used as prophylactic on mass scale due to risk of severe reaction in some individuals: A. Mefloquine B. Amodiaquine C. Primaquine D. Pyrimethamine
Last Answer : C. Primaquine
Description : Which antileprotic drug suppresses lepra reaction and reversal reaction as well: A. Dapsone B. Rifampin C. Clofazimine D. Minocycline
Last Answer : C. Clofazimine
Description : Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin
Last Answer : B. Ticlopidine
Description : The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is: A. Aspirin B. Procaine C. Morphine D. Sulfadiazine
Last Answer : C. Morphine
Description : The following allergic drug reaction is caused by circulating antibodies: A. Serum sickness B. Anaphylactic shock C. Systemic lupus erythematosus D. Angioedema
Last Answer : A. Serum sickness
Description : An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is: A. Hypersensitivity B. Supersensitivity C. Intolerance D. Idiosyncrasy
Last Answer : A. Hypersensitivity
Description : Which of the following is an idiosyncratic adverse drug reaction: A. Muscle dystonia caused by triflupromazine B. Insomnia after taking pentobarbitone C. Precipitation of asthma by morphine D. Gum hyperplasia caused by phenytoin
Last Answer : B. Insomnia after taking pentobarbitone
Description : Which of the following reaction is spontaneous oxidation - reduction reaction
Last Answer : Which of the following reaction is spontaneous oxidation - reduction reaction A. `Mn^(+2)+5Fe^(+3)+4H_(2) ... OrarrMnO_(4)^(-)+5Fe^(+3)+8H^(+)`
Description : Which of the following reaction involves oxidation reduction?
Last Answer : Which of the following reaction involves oxidation reduction? A. `NaBr+Hclrarr NaCl+HBr` B. `HBr + AgNO_(3)rarr ... )O` D. `H_(2)+Br_(2) rarr 2HBr`
Description : In the above chemical reaction which element does undergo oxidation and which does undergo reduction?
Last Answer : 2Na(s) + H2(g) \(\overset{\Delta}\longrightarrow\) 2NaH(s) In the above ... element does undergo oxidation and which does undergo reduction?
Description : The working of a dry cell is based on - (1) Decomposition reaction (2) Spontaneous oxidation-reduction reaction (3) Combination reaction. (4) Electrolysis
Last Answer : (4) Electrolysis Explanation: A dry cell is a type of battery that uses a paste electrolyte, with only enough moisture to allow current to flow. It works in accordance with Faraday's law of ... of the cell (the positive electrode), and the space between them is filled with an electrolyte paste.
Description : The reaction between an acid and a base to give a salt and water is known as a - (1) Neutralisation reaction (2) Reduction reaction (3) Oxidation reaction (4) Exothermic reaction
Last Answer : (1) Neutralisation reaction Explanation: The effect of a base is nullified by an acid and vice-versa. Example: Reaction of Sodium hydroxide with hydrochloric acidNaOH(aq) + HCl(aq) → NaCl(aq) + H2O(l)
Description : The reaction between methane and chlorine in diffused sunlight is-----? A. Oxidation B. Reduction C. Polymerisation D. Radical substitution (Answer)
Last Answer : D. Radical substitution (Answer)
Description : During decomposition, energy is absorbed in the form of heat, light or electricity for breaking down the reactants which is known as: (a) exothermic reaction (b) endothermic reaction (c) reduction reaction (d) oxidation
Last Answer : (b) endothermic reaction