The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug B. Dose of thiazide diuretic should be 12.5-25 mg hydrochlorothiazide or equivalent per day C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately D. If the drug chosen initially fails to lower BP, it should be replaced by a drug/combination from another class

The principles of antihypertensive drug usage
enunciated in JNC VI and WHO-ISH guidelines include
the following except:
A. Therapy for grade I and II hypertension
should be initiated with a single drug
B. Dose of thiazide diuretic should be 12.5-25
mg hydrochlorothiazide or equivalent per day
C. All subjects with BP higher than 140/90
mmHg should be put on antihypertensive
medication immediately
D. If the drug chosen initially fails to lower BP,
it should be replaced by a drug/combination
from another class
by

1 Answer

Answer :

C. All subjects with BP higher than 140/90
mmHg should be put on antihypertensive
medication immediately
by

Related questions

A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished and ascitis again appeared. Select the measure to reinduce diuresis: A. Increase hydrochlorothiazide dose to 100 mg twice daily B. Add acetazolamide 250 mg twice daily C. Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Description : A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished ... Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Last Answer : C. Add spironolactone 50 mg thrice daily

Officially, hypertension is diagnosed when the patient demonstrates a systolic blood pressure greater than ______ mm Hg and a diastolic blood pressure greater than _____ mm Hg over a sustained period. a) 140, 90 According to the categories of blood pressure levels established by the JNC VI, stage 1 hypertension is demonstrated by a systolic pressure of 140–159 or a diastolic pressure of 90–99.

Description : Officially, hypertension is diagnosed when the patient demonstrates a systolic blood pressure greater than ______ mm Hg and a diastolic blood pressure greater than _____ mm Hg over a sustained period. a) ... , 70 Pressure of 120 systolic and 70 diastolic falls within the normal range for an adult.

Last Answer : a) 140, 90 According to the categories of blood pressure levels established by the JNC VI, stage 1 hypertension is demonstrated by a systolic pressure of 140–159 or a diastolic pressure of 90–99.

A fixed dose combination preparation meant for internal use must not contain the following class of drug: A. Thiazide diuretic B. Fluoroquinolone antimicrobial C. Corticosteroid D. H2 blocker

Description : A fixed dose combination preparation meant for internal use must not contain the following class of drug: A. Thiazide diuretic B. Fluoroquinolone antimicrobial C. Corticosteroid D. H2 blocker

Last Answer : C. Corticosteroid

An elderly hypertensive was treated with hydrochlorothiazide 50 mg daily. Even after a month, his BP was not reduced to the desired level and another antihypertensive was added. After 2 hours of taking the other drug his BP fell precipitously. The most likely other drug given to him is: A. Atenolol B. Captopril C. Methyldopa D. Amlodipine

Description : An elderly hypertensive was treated with hydrochlorothiazide 50 mg daily. Even after a month, his BP was not reduced to the desired level and another antihypertensive was added. After 2 hours of taking the ... likely other drug given to him is: A. Atenolol B. Captopril C. Methyldopa D. Amlodipine

Last Answer : B. Captopril

n the treatment of hypertension the beta adrenergic blockers have the following advantage: A. They have minimal effect on work capacity, sleep quality and libido B. They do not cause postural hypotension C. Used alone, they have high ceiling antihypertensive efficacy D. They can be used in combination with any other antihypertensive drug

Description : n the treatment of hypertension the beta adrenergic blockers have the following advantage: A. They have minimal effect on work capacity, sleep quality and libido B. They do not cause ... high ceiling antihypertensive efficacy D. They can be used in combination with any other antihypertensive drug

Last Answer : B. They do not cause postural hypotension

The following is not a feature of thiazide diuretics used as antihypertensive: A. They do not cause symptomatic postural hypotension B. The dose has to be titrated over a wide range according to the response C. They restore responsiveness to other antihypertensives when tolerance has developed D. They decrease renal calcium excretion which may improve calcium balance in elderly patients

Description : The following is not a feature of thiazide diuretics used as antihypertensive: A. They do not cause symptomatic postural hypotension B. The dose has to be titrated over a wide range ... has developed D. They decrease renal calcium excretion which may improve calcium balance in elderly patients

Last Answer : B. The dose has to be titrated over a wide range according to the response

The following antihypertensive combination is irrational, and therefore should not be used: A. Nifedipine + hydralazine B. Amlodipine + atenolol C. Enalapril + clonidine D. Enalapril + hydrochlorothiazide

Description : The following antihypertensive combination is irrational, and therefore should not be used: A. Nifedipine + hydralazine B. Amlodipine + atenolol C. Enalapril + clonidine D. Enalapril + hydrochlorothiazide

Last Answer : TA. Nifedipine + hydralazine

6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should be done to the oral prednisolone medication after starting inhaled beclomethasone: A. It should be stopped immediately B. Its dose should be tapered from the next day C. It should be given at the same dose for one week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2

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Last Answer : C. It should be given at the same dose for one week and then tapered

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Last Answer : D. Both 'B' and 'C' are correct

A 40-year-old politician suffered from attacks of chest pain diagnosed as angina pectoris. He had a tense personality, resting heart rate was 96/min, blood pressure 170/104 mm Hg, but blood sugar level and lipid profile were normal. Select the most suitable antihypertensive for initial therapy in his case: A. Nifedipine B. Hydrochlorothiazide C. Atenolol D. Methyldopa

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Last Answer : C. Atenolol

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Last Answer : D. Both ‘B‘ and ‘C

As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost

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Last Answer : A. High ceiling antihypertensive action

The following antihypertensive drug has a favourable effect on plasma lipid profile: A. Prazosin B. Propranolol C. Hydrochlorothiazide D. Furosemide

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Individual drugs of thiazide and related class of diuretics differ markedly from each other in the following respect? A. Diuretic efficacy B. Diuretic potency C. Side effects D. Propensity to cause hyperkalemia

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A woman in the 28th week of pregnancy has developed pregnancy induced hypertension with a blood pressure reading of 150/100 mm Hg. Select the most appropriate antihypertensive drug for her: A. Furosemide B. Methyldopa C. Propranolol D. Captopril

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Select the correct statement about combining antihypertensive drugs: A. Antihypertensive combinations should always be preferred over single drugs B. Combinations of antihypertensives with similar pattern of haemodynamic action are superior to those with dissimilar pattern C. Antihypertensives which act on different regulatory systems maintaining blood pressure should be combined D. A diuretic must be included whenever antihypertensives are combined

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Low dose therapy with the following category of antihypertensive drugs has been found to be more advantageous in the long-term than high dose therapy with the same drugs: A. β adrenergic blockers B. α1 adrenergic blockers C. Central sympatholytics D. Diuretics

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Last Answer : D. Diuretics

63. A hypertensive client is taking herbal supplement for his hypertension. He was prescribed antihypertensive medication. The client wants to continue taking his herbal medication to lower his blood pressure. The nurse’s most appropriate action is to

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Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes

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The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

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Last Answer : D. Both ‘A’ and ‘C’ are correct

At equinatriuretic doses which diuretic causes the maximum K+ loss: A. Furosemide B. Hydrochlorothiazide C. Acetazolamide D. Amiloride

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Last Answer : C. Acetazolamide

The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone

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The preferred diuretic for mobilizing edema fluid in CHF is: A. Hydrochlorothiazide B. Furosemide C. Metolazone D. Amiloride

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A visitor from another city comes to your office complaining of incessant cough. He has diabetes and hypertension and has recently started taking a different antihypertensive medication. The most likely cause of his cough is (a) Enalapril (b) Losartan (c) Minoxidil (d) Propranolol (e) Verapamil

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A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone

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Last Answer : Ans: A

Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension

Description : Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension

Last Answer : A. Pregnancy induced hypertension

Rebound hypertension on sudden stoppage of medication is most likely to occur with: A. Hydrochlorothiazide B. Prazosin C. Clonidine D. Lisinopri

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Last Answer : C. Clonidine

The daily dose of estrogen for hormone replacement therapy in postmenopausal women is: A. Same as for contraception B. Higher than that for contraception C. Lower than that for contraception D. Variable depending on the age of the woman

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Last Answer : C. Lower than that for contraception

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Last Answer : A. Delayed onset; blood pressure starts falling after 1–2 weeks therapy

Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs): A. NSAIDs attenuate hypoglycaemic action of sulfonylureas B. NSAIDs potentiate antihypertensive action of ACE inhibitors C. Serum lithium levels are lowered by concurrent administration of NSAIDs D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding

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Last Answer : D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding

Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs C. They do not worsen blood lipid profile D. They do not impair work performance

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Last Answer : B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs

Methyldopa differs from clonidine in the following respect: A. It is less likely to cause rebound hypertension on sudden discontinuation B. It does not reduce plasma renin activity C. It has a central as well as peripheral site of antihypertensive action D. It does not produce central side effect

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Last Answer : A. It is less likely to cause rebound hypertension on sudden discontinuation

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Last Answer : D. All of the abov

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Last Answer : B. Ventricular extrasystoles

Which of the following feature(s) limit(s) the use of prazosin as a first line antihypertensive drug: A. Higher incidence of disturbing side effects B. Unfavourable metabolic effects C. Development of tolerance when used alone D. Both ‘A’ and ‘C’ are correct

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Last Answer : D. Both ‘A’ and ‘C’ are correct

Higher incidence of myocardial infarction and increased mortality has been noted with the use of the following antihypertensive drug: A. Nifedipine B. Verapamil C. Diltiazem D. Lisinopril

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The following antihypertensive drug tends to lower plasma renin activity: A. Clonidine B. Hydralazine C. Nifedipine D. Captopril

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An epileptic woman controlled by phenytoin therapy conceives. Which of the following measures is most appropriate: A. Medical termination of pregnancy B. Withdraw phenytoin therapy C. Gradually reduce phenytoin dose to the lowest effective level D. Substitute phenytoin with a combination of carbamazepine and sodium valproate

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The following is correct about antipsychotic drugs except: A. They only control symptoms of schizophrenia without affecting the basic disorder B. Combination of two or more antipsychotic drugs is more efficacious than any single drug C. In treating psychosis high potency drugs are preferred over low potency drugs D. They donot produce dependence

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