The metabolic reaction requiring vitamin B12 but not folate is: A. Conversion of malonic acid to succinic acid B. Conversion of homocysteine to methionine C. Conversion of serine to glycine D. Thymidylate synthesis

The metabolic reaction requiring vitamin B12 but not
folate is:
A. Conversion of malonic acid to succinic acid
B. Conversion of homocysteine to methionine
C. Conversion of serine to glycine
D. Thymidylate synthesis
by

1 Answer

Answer :

A. Conversion of malonic acid to succinic acid
by

Related questions

Methylcobalamin is required for formation of (A) Serin from glycine (B) Glycine from serine (C) Methionine from homocysteine (D) All of these

Description : Methylcobalamin is required for formation of (A) Serin from glycine (B) Glycine from serine (C) Methionine from homocysteine (D) All of these

Last Answer : Answer : C

Both folic acid and methyl cobalamin (vitamin B12) are required in (A) Deamination of serine (B) Deamination of threonine (C) Conversion of pyridoxal phosphate to pyridoxamine phosphate (D) Methylation of homocystein to methionine

Description : Both folic acid and methyl cobalamin (vitamin B12) are required in (A) Deamination of serine (B) Deamination of threonine (C) Conversion of pyridoxal phosphate to pyridoxamine phosphate (D) Methylation of homocystein to methionine

Last Answer : Answer : D

That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises the action of sulfonamides C. Purines and thymidine present in pus antagonise the action of sulfonamides D. Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides

Description : That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises ... . Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides

Last Answer : B. Methionine antagonises the action of sulfonamides

Methionine is synthesized in human body from (A) Cysteine and homoserine (B) Homocysteine and serine (C) Cysteine and serine (D) None of these

Description : Methionine is synthesized in human body from (A) Cysteine and homoserine (B) Homocysteine and serine (C) Cysteine and serine (D) None of these

Last Answer : Answer : D

Cysteine can be synthesized from methionine and (A) Serine (B) Homoserine (C) Homocysteine (D) Threonine

Description : Cysteine can be synthesized from methionine and (A) Serine (B) Homoserine (C) Homocysteine (D) Threonine

Last Answer : Answer : A

A patient of megaloblastic anaemia was treated with oral folic acid 5 mg daily. After 2 weeks he reported back with cognitive deficit, sensory disturbance, depressed knee jerk, while blood picture and haemoglobin level were improved. What could be the most likely explanation: A. Folic acid was not adequately absorbed resulting in partial response B. Folate therapy has precipitated vitamin B12 deficiency in the neural tissue C. Folate therapy has unmasked pyridoxine deficiency D. Patient has folate reductase abnormality in the nervous system

Description : A patient of megaloblastic anaemia was treated with oral folic acid 5 mg daily. After 2 weeks he reported back with cognitive deficit, sensory disturbance, depressed knee jerk, while ... therapy has unmasked pyridoxine deficiency D. Patient has folate reductase abnormality in the nervous system

Last Answer : D. Patient has folate reductase abnormality in the nervous system

Megaloblastic anaemia developing under the following condition is due entirely to folate deficiency not associated with vitamin B12 deficiency: A. Malnutrition B. Blind loop syndrome C. Phenytoin therapy D. Pregnancy

Description : Megaloblastic anaemia developing under the following condition is due entirely to folate deficiency not associated with vitamin B12 deficiency: A. Malnutrition B. Blind loop syndrome C. Phenytoin therapy D. Pregnancy

Last Answer : C. Phenytoin therapy

Features of methylcobalamin include the following: A. It is an active coenzyme form of vit B12 B. It is required for the synthesis of S-adenosyl methionine C. It is specifically indicated for correcting neurological defects of vit B12 deficiency D. All of the above

Description : Features of methylcobalamin include the following: A. It is an active coenzyme form of vit B12 B. It is required for the synthesis of S-adenosyl methionine C. It is specifically indicated for correcting neurological defects of vit B12 deficiency D. All of the above

Last Answer : D. All of the above

In mammalian tissues serine can be a biosynthetic precursor of (A) Methionine (B) Glycine (C) Tryptophan (D) Phenylalanine

Description : In mammalian tissues serine can be a biosynthetic precursor of (A) Methionine (B) Glycine (C) Tryptophan (D) Phenylalanine

Last Answer : Answer : B

A biochemical indication of vitamin B12 deficiency can be obtained by measuring the urinary excretion of (A) Pyruvic acid (B) Malic acid (C) Methyl malonic acid (D) Urocanic acid

Description : A biochemical indication of vitamin B12 deficiency can be obtained by measuring the urinary excretion of (A) Pyruvic acid (B) Malic acid (C) Methyl malonic acid (D) Urocanic acid

Last Answer : Answer : C

Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12

Description : Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12

Last Answer : Answer : D

Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12

Description : Methyl malonic aciduria is seen in a deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12

Last Answer : Answer : D

Methyl malonic aciduria is seen in the deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12

Description : Methyl malonic aciduria is seen in the deficiency of (A) Vitamin B6 (B) Folic acid (C) Thiamine (D) Vitamin B12

Last Answer : Answer : D

In E. coli the chain initiating amino acid in protein synthesis is (A) N-formyl methionine(B) Methionine (C) Serine (D) Cysteine

Description : In E. coli the chain initiating amino acid in protein synthesis is (A) N-formyl methionine(B) Methionine (C) Serine (D) Cysteine

Last Answer : Answer : A

The amino terminal of all polypeptide chain at the time of synthesis in E. coli is tagged to the amino acid residue: (A) Methionine (B) Serine (C) N-formyl methinine(D) N-formal serine

Description : The amino terminal of all polypeptide chain at the time of synthesis in E. coli is tagged to the amino acid residue: (A) Methionine (B) Serine (C) N-formyl methinine(D) N-formal serine

Last Answer : Answer : C

An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide

Description : An example of competitive inhibition of an enzyme is the inhibition of a. Succinic dehydrogenase by malonic acid b. Cytochrome oxidase by cyanide c. Hexokinase by glucose-6-phosphate d. Carbonic anhydrase by carbon dioxide

Last Answer : Ans: A

An amino acid required for porphyrin synthesis is (A) Proline (B) Glycine (C) Serine (D) Histidine

Description : An amino acid required for porphyrin synthesis is (A) Proline (B) Glycine (C) Serine (D) Histidine

Last Answer : Answer : A

An amino acid which contains a disulphide bond is (A) Lysine (B) Methionine (C) Homocysteine (D) Cystine

Description : An amino acid which contains a disulphide bond is (A) Lysine (B) Methionine (C) Homocysteine (D) Cystine

Last Answer : Answer : D

A coenzyme required for the synthesis of glycine from serine is (A) ATP (B) Pyridoxal phosphate (C) Tetrahydrofolate (D) NAD

Description : A coenzyme required for the synthesis of glycine from serine is (A) ATP (B) Pyridoxal phosphate (C) Tetrahydrofolate (D) NAD

Last Answer : Answer : C

The amino acids involved in the synthesis of creatin are (A) Arginine, glycine, active methionine (B) Arginine, alanine, glycine (C) Glycine, lysine, methionine (D) Arginine, lysine, methionine

Description : The amino acids involved in the synthesis of creatin are (A) Arginine, glycine, active methionine (B) Arginine, alanine, glycine (C) Glycine, lysine, methionine (D) Arginine, lysine, methionine

Last Answer : Answer : A

Cobalt forms an integral part of the vitamin: (A) B1 (B) B6 (C) B12 (D) Folate

Description : Cobalt forms an integral part of the vitamin: (A) B1 (B) B6 (C) B12 (D) Folate

Last Answer : Answer : C

A hypochromic microcytic anemia with increased iron stores in the bone marrow may be (A) Iron responsive (B) Pyridoxine responsive (C) Vitamin B12 responsive (D) Folate responsive

Description : A hypochromic microcytic anemia with increased iron stores in the bone marrow may be (A) Iron responsive (B) Pyridoxine responsive (C) Vitamin B12 responsive (D) Folate responsive

Last Answer : Answer : B

Serum ferritin is a maker of Options: 1) Circulating Iron 2) Storage iron 3) Folate 4) Vitamin B12 Levels

Description : Serum ferritin is a maker of Options: 1) Circulating Iron 2) Storage iron 3) Folate 4) Vitamin B12 Levels

Last Answer : Correct Answer: 2) Storage iron

Conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by the enzyme: (A) Ribonucleotide reductase (B) Thymidylate synthetase (C) CTP synthetase (D) Orotidylic acid decarboxylase

Description : Conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by the enzyme: (A) Ribonucleotide reductase (B) Thymidylate synthetase (C) CTP synthetase (D) Orotidylic acid decarboxylase

Last Answer : Answer : B

Megaloblastic anaemia occurs in: A. Vitamin B12 but not folic acid deficiency B. Folic acid but not Vitamin B12 deficiency C. Either Vitamin B12 or folic acid deficiency D. Only combined Vitamin B12 + folic acid deficiency

Description : Megaloblastic anaemia occurs in: A. Vitamin B12 but not folic acid deficiency B. Folic acid but not Vitamin B12 deficiency C. Either Vitamin B12 or folic acid deficiency D. Only combined Vitamin B12 + folic acid deficiency

Last Answer : C. Either Vitamin B12 or folic acid deficiency

The sulphur containing amino acid: (A) Homoserine (B) Serine (C) Methionine (D) Valine

Description : The sulphur containing amino acid: (A) Homoserine (B) Serine (C) Methionine (D) Valine

Last Answer : Answer : C

An amino acid having a hydrophilic side chain is (A) Alanine (B) Proline (C) Methionine (D) Serine

Description : An amino acid having a hydrophilic side chain is (A) Alanine (B) Proline (C) Methionine (D) Serine

Last Answer : Answer : D

An essential amino acid in man is (A) Aspartate (B) Tyrosine (C) Methionine (D) Serine

Description : An essential amino acid in man is (A) Aspartate (B) Tyrosine (C) Methionine (D) Serine

Last Answer : Answer : C

A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had hypersegmented nuclei. Endoscopy revealed atrophic gastritis. Deficiency of which factor is likely to be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin

Description : A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had ... be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin

Last Answer : B. Vitamin B12

The following factor(s) is/are required for the absorption of dietary vitamin B12: A. Gastric acid B. Gastric intrinsic factor C. Transcobalamine D. Both ‘A’ and ‘B’

Description : The following factor(s) is/are required for the absorption of dietary vitamin B12: A. Gastric acid B. Gastric intrinsic factor C. Transcobalamine D. Both ‘A’ and ‘B’

Last Answer : D. Both ‘A’ and ‘B

Carbon 6-of purine skeleton comes from (A) Atmospheric CO2 (B) 1 carbon carried by folate (C) Betoine (D) Methionine

Description : Carbon 6-of purine skeleton comes from (A) Atmospheric CO2 (B) 1 carbon carried by folate (C) Betoine (D) Methionine

Last Answer : Answer : A

In A chain of the insulin molecule the Nterminal amino acid is (A) Glycine (B) Valine (C) Serine (D) Phenylalanine

Description : In A chain of the insulin molecule the Nterminal amino acid is (A) Glycine (B) Valine (C) Serine (D) Phenylalanine

Last Answer : Answer : A

A compound normally used to conjugate bile acids is (A) Serine (B) Glycine (C) Glucoronic acid (D) Fatty acid

Description : A compound normally used to conjugate bile acids is (A) Serine (B) Glycine (C) Glucoronic acid (D) Fatty acid

Last Answer : Answer : B

2-Amino 3-OH propanoic acid is (A) Glycine (B) Alanine (C) Valine (D) Serine

Description : 2-Amino 3-OH propanoic acid is (A) Glycine (B) Alanine (C) Valine (D) Serine

Last Answer : Answer : D

In glutathione (a tripeptide) is present apart from Glutamic acid and cysteine: (A) Serine (B) Glycine (C) Leucine (D) Phenyl alanine

Description : In glutathione (a tripeptide) is present apart from Glutamic acid and cysteine: (A) Serine (B) Glycine (C) Leucine (D) Phenyl alanine

Last Answer : Answer : B

Collagen is very rich in (A) Glycine (B) Serine (C) Aspartic acid (D) Glutamic acid

Description : Collagen is very rich in (A) Glycine (B) Serine (C) Aspartic acid (D) Glutamic acid

Last Answer : Answer : A

The amino acid which detoxicated benzoic acid to form hippuric acid is (A) Glycine (B) Alanine (C) Serine (D) Glutamic acid

Description : The amino acid which detoxicated benzoic acid to form hippuric acid is (A) Glycine (B) Alanine (C) Serine (D) Glutamic acid

Last Answer : Answer : A

Small amount of urinary oxalates is contributed by the amino acid: (A) Glycine (B) Tyrosine (C) Alanine (D) Serine

Description : Small amount of urinary oxalates is contributed by the amino acid: (A) Glycine (B) Tyrosine (C) Alanine (D) Serine

Last Answer : Answer : A

The optically inactive amino acid is (A) Glycine (B) Serine (C) Threonine (D) Valine

Description : The optically inactive amino acid is (A) Glycine (B) Serine (C) Threonine (D) Valine

Last Answer : Answer : A

The substrate for photorespiration is (a) phosphoglyceric acid (b) glycolate (c) serine (d) glycine.

Description : The substrate for photorespiration is (a) phosphoglyceric acid (b) glycolate (c) serine (d) glycine.

Last Answer : (b) glycolate

The optically inactive amino acid is (A) Glycine (B) Serine (C) Threonine (D) Valine

Description : The optically inactive amino acid is (A) Glycine (B) Serine (C) Threonine (D) Valine

Last Answer : (A) Glycine

The first amino acid incorporated in a polypeptide in a ribosome of a bacterium is (A) N formyl methionine (B) Methionine (C) Alamine (D) Glycine

Description : The first amino acid incorporated in a polypeptide in a ribosome of a bacterium is (A) N formyl methionine (B) Methionine (C) Alamine (D) Glycine

Last Answer : Answer : A

Sulphur containing amino acid (A)Lysine (B) Methionine (C)Glutamine (D) Glycine

Description : Sulphur containing amino acid (A)Lysine (B) Methionine (C)Glutamine (D) Glycine

Last Answer : (B) Methionine

Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase gene so that the enzyme is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis

Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis

Last Answer : Answer : B

Vitamin necessary for CoA synthesis: (A) Pantothenic acid (B) Vitamin C (C) B6 (D) B12

Description : Vitamin necessary for CoA synthesis: (A) Pantothenic acid (B) Vitamin C (C) B6 (D) B12

Last Answer : Answer : A

In Krebs’ cycle, the FAD precipitates as electron acceptor during the conversion of (a) fumaric acid to malic acid (b) succinic acid to fumaric acid (c) succinyl CoA to succinic acid (d) α-ketoglutarate to succinyl CoA.

Description : In Krebs’ cycle, the FAD precipitates as electron acceptor during the conversion of (a) fumaric acid to malic acid (b) succinic acid to fumaric acid (c) succinyl CoA to succinic acid (d) α-ketoglutarate to succinyl CoA.

Last Answer : (b) succinic acid to fumaric acid

Which statement is wrong for Krebs’ cycle? (a) There is one point in the cycle where FAD+ is reduced to FADH2. (b) During conversion of succinyl CoA to succinic acid, a molecule of GTP is synthesised. (c) The cycle starts with condensation of acetyl group (acetyl CoA) with pyruvic acid to yield citric acid. (d) There are three points in the cycle where NAD+ is reduced to NADH + H+.

Description : Which statement is wrong for Krebs' cycle? (a) There is one point in the cycle where FAD+ is reduced to FADH2. (b) During conversion of succinyl CoA to succinic acid, a molecule of GTP is synthesised. (c ... citric acid. (d) There are three points in the cycle where NAD+ is reduced to NADH + H+.

Last Answer : (c) The cycle starts with condensation of acetyl group (acetyl CoA) with pyruvic acid to yield citric acid.

The vitamin that is regarded to be a hormone is: A. Vitamin D B. Vitamin C C. Vitamin B12 D. Vitamin A

Description : The vitamin that is regarded to be a hormone is: A. Vitamin D B. Vitamin C C. Vitamin B12 D. Vitamin A

Last Answer : A. Vitamin D

Metformin is preferred over phenformin because: A. It is more potent B. It is less liable to cause lactic acidosis C. It does not interfere with vitamin B12 absorption D. It is not contraindicated in patients with kidney disease

Description : Metformin is preferred over phenformin because: A. It is more potent B. It is less liable to cause lactic acidosis C. It does not interfere with vitamin B12 absorption D. It is not contraindicated in patients with kidney disease

Last Answer : B. It is less liable to cause lactic acidosis

Main metabolic end product of cholesterol: (A) Coprosterol (B) 5-pregnenolone (C) Bile acid (D) Glycine

Description : Main metabolic end product of cholesterol: (A) Coprosterol (B) 5-pregnenolone (C) Bile acid (D) Glycine

Last Answer : Answer : C