Gram negative organisms are largely insensitive to benzyl penicillin because: A. They produce large quantities of penicillinase B. They do not utilise D-alanine whose incorporation in the cell wall is inhibited by benzylpenicillin C. Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multilayer cell wall of gram negative bacteria D. Both ‘A’ and ‘B’ are correct

Gram negative organisms are largely insensitive to
benzyl penicillin because:
A. They produce large quantities of penicillinase
B. They do not utilise D-alanine whose incorporation in the cell wall is inhibited by benzylpenicillin
C. Benzyl penicillin is not able to penetrate
deeper into the lipoprotein-peptidoglycan
multilayer cell wall of gram negative bacteria
D. Both ‘A’ and ‘B’ are correct
by

1 Answer

Answer :

. Benzyl penicillin is not able to penetrate
deeper into the lipoprotein-peptidoglycan
multilayer cell wall of gram negative bacteria
by

Related questions

Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is inhibited by benzyl penicillin (c) Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Description : Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is ... lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Last Answer : Ans: C

Choose the semisynthetic penicillin which has an extended spectrum of activity against many gram negative bacilli, is acid resistant but not penicillinase resistant: A. Cloxacillin B. Amoxicillin C. Phenoxymethyl penicillin D. Piperacillin

Description : Choose the semisynthetic penicillin which has an extended spectrum of activity against many gram negative bacilli, is acid resistant but not penicillinase resistant: A. Cloxacillin B. Amoxicillin C. Phenoxymethyl penicillin D. Piperacillin

Last Answer : B. Amoxicillin

That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises the action of sulfonamides C. Purines and thymidine present in pus antagonise the action of sulfonamides D. Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides

Description : That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises ... . Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides

Last Answer : B. Methionine antagonises the action of sulfonamides

Gram-negative bacteria would stain_________ with the Gram stain and have _______in the wall. a. orange-red; Teichoic acid b. orange-red; lipopolysaccharide c. purple; peptidoglycan d. purple; Teichoic acid

Description : Gram-negative bacteria would stain_________ with the Gram stain and have _______in the wall. a. orange-red; Teichoic acid b. orange-red; lipopolysaccharide c. purple; peptidoglycan d. purple; Teichoic acid

Last Answer : c. purple; peptidoglycan

Which of the following is a second generation cephalosporin that is highly resistant to gram negative β-lactamases, and cures penicillinase positive as well as negative gonococcal infection by a single intramuscular dose: A. Cephalexin B. Cefuroxime C. Cefoperazone D. Ceftazidime

Description : Which of the following is a second generation cephalosporin that is highly resistant to gram negative β-lactamases, and cures penicillinase positive as well as negative gonococcal infection by a single intramuscular dose: A. Cephalexin B. Cefuroxime C. Cefoperazone D. Ceftazidime

Last Answer : B. Cefuroxime

Semisynthetic penicillins developed so far have overcome the following drawbacks of benzylpenicillin except: A. Lack of efficacy against gram negative bacilli B. Susceptibility to bacterial penicillinase C. Inactivation by gastric acid D. Potential to cause hypersensitivity reactions

Description : Semisynthetic penicillins developed so far have overcome the following drawbacks of benzylpenicillin except: A. Lack of efficacy against gram negative bacilli B. Susceptibility to bacterial penicillinase C. Inactivation by gastric acid D. Potential to cause hypersensitivity reactions

Last Answer : D. Potential to cause hypersensitivity reactions

Porins are located in A- the outer membrane of gram-negative bacteria B- he peptidoglycan layer of gram-positive bacteria C- the cytoplasmic membrane of both gram-negative and gram-positive bacteria D- the periplasmic space of gram-negative bacteria

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Last Answer : the outer membrane of gram-negative bacteria

Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct

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Last Answer : D. All of the above are correct

Penicillins interfere with bacterial cell wall synthesis by (a) Inhibiting synthesis of N-acetyl muramic acid pentapeptide (b) Inhibiting conjugation between N-acetyl muramic acid and N-acetyl glucosamine (c) Inhibiting transpeptidases and carboxy peptidases which cross link the peptidoglycan residues (d) Counterfeiting for D-alanine in the bacterial cell wall

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Last Answer : Ans: C

The most likely explanation of differing sensitivities of different bacteria to various penicillins is: A. Differing susceptibilities of the various penicillins to β-lactamases produced by different bacteria B. Differing affinities of penicillin binding proteins present in different bacteria towards various penicillins C. Differing penetrability of various penicillins into different bacteria D. Differing rates of cell wall synthesis by different bacteria

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Last Answer : B. Differing affinities of penicillin binding proteins present in different bacteria towards various penicillins

Intradermal test for penicillin sensitivity should be performed by injecting the following quantity of sodium benzyl penicillin: A. 10 U B. 100 U C. 1000 U D. 5000 U

Description : Intradermal test for penicillin sensitivity should be performed by injecting the following quantity of sodium benzyl penicillin: A. 10 U B. 100 U C. 1000 U D. 5000 U

Last Answer : A. 10 U

Which of the following may be most likely to be missing from a gram-positive bacterium? A.Penicillin binding protein B.Peptidoglycan C.Lipopolysaccharide D.Phospholipid bilayer membrane

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Last Answer : C.Lipopolysaccharide

The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely

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Last Answer : D. COX-1 is constitutive while COX-2 is largely

The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity

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Last Answer : B. It acts by inhibiting bacterial protein synthesis

Leishmania donovani is susceptible to certain antifungal drugs because both fungi and Leishmania: A. Utilise purine salvage pathway B. Utilise similar glycolytic mechanisms C. Have similar topoisomerase II enzyme D. Have ergosterol in their cell membranes

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Last Answer : D. Have ergosterol in their cell membranes

Amoxicillin + Clavulanic acid is active against the following organisms except: A. Methicillin resistant Staph. aureus B. Penicillinase producing Staph. aureus C. Penicillinase producing N.gonorrhoeae D. β-lactamase producing E.coli

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The following statement is not true of sulbactam: A. It is a broad spectrum β-lactamase inhibitor B. It does not augment the activity of ampicillin against bacteria that are sensitive to the latter C. It induces chromosomal β-lactamases D. Combined with ampicillin, it is highly effective against penicillinase producing N. gonorrhoeae

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Indicate the attribute that is common to both polymyxin B and bacitracin: A. Both are active against gram negative bacteria B. Both are too toxic for systemic use C. Both act by inhibiting bacterial cell wall synthesis D. Both a

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Last Answer : B. Both are too toxic for systemic use

Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme C. It inhibits bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above

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Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme

Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms

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Superinfections are more common with: A. Use of narrow spectrum antibiotics B. Short courses of antibiotics C. Use of antibiotics that are completely absorbed from the small intestines D. Use of antibiotic combinations covering both gram positive and gram negative bacteria

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If a necrotizing soft tissue infection is considered, therapy mandates: a. Empiric administration of antibiotics active against gram-positive, gram-negative, and anaerobic bacteria b. Due to usually resistant species, penicillin is not indicated c. Immediate operative intervention and aggressive resection of all involved tissues is mandatory d. The use of hyperbaric oxygen has been demonstrated to be clearly advantageous

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Choose the correct statement about cysteinyl leukotrienes (LT-C4/D4): A. They produce long lasting bronchoconstriction B. They produce sustained rise in blood pressure C. They are responsible for attracting and sequestrating neutrophils at the site of inflammation D. Their production is inhibited by rofecoxib

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Last Answer : A. They produce long lasting bronchoconstriction

The cell wall of A.gram-positive bacteria are thicker than gram-negative bacteria B.gram-negative bacteria are thicker than gram-positive bacteria C.both have same thickness but composition is different D.none of these

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Last Answer : A.gram-positive bacteria are thicker than gram-negative bacteria

The cell wall of A- gram-positive bacteria are thicker than gram-negative bacteria B- gram-negative bacteria are thicker than gram-positive bacteria C- both have same thickness but composition is different D- none of these

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Last Answer : gram-positive bacteria are thicker than gram-negative bacteria

Tetracyclines are active against the following gram negative bacteria: A. Salmonella typhi B. Pseudomonas aeruginosa C. Yersinia pestis D. All of the above

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What is true of cefpirome: A. It is a fourth generation cephalosporin B. It easily penetrates porin channels of gram negative bacteria C. It inhibits type I β-lactamase producing enterobacteriaceae D. All of the above

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Last Answer : . All of the above

Distinctive features of gatifloxacin include the following except: A. Higher affinity for the enzyme topoisomerase IV B. Activity restricted to gram negative bacteria C. Potential to prolong QTc interval D. Employed to treat community acquired pneumonia

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Nalidixic acid is primarily active against: A. Cocci B. Bacilli C. Gram positive bacteria D. Gram negative bacteria

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Penicillins interfere with bacterial cell wall synthesis by: A. Inhibiting synthesis of N-acetyl muramic acid pentapeptide B. Inhibiting conjugation between N-acetyl muramic acid and N-acetyl glucosamine C. Inhibiting transpeptidases and carboxypeptidases which cross link the peptidoglycan residues D. Counterfeiting for D-alanine in the bacterial cell wall

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Last Answer : C. Inhibiting transpeptidases and carboxypeptidases which cross link the peptidoglycan residues

Select the correct combination of the statements (i-iv) regarding the characteristics of certain organisms. (i) Methanogens are archaebacteria which produce methane in marshy areas. (ii) Nostoc is a filamentous blue-green alga which fixes atmospheric nitrogen. (iii)Chemosynthetic autotrophic bacteria synthesize cellulose from glucose. (iv) Mycoplasma lack a cell wall and can survive without oxygenThe correct statements are (a) (ii) and (iii) (b) (i),(ii) and (iii) (c) (ii), (iii) and (iv) (d) (i), (ii) and (iv)..

Description : Select the correct combination of the statements (i-iv) regarding the characteristics of certain organisms. (i) Methanogens are archaebacteria which produce methane in marshy areas. (ii) Nostoc is a filamentous blue-green alga which fixes ... iii) (c) (ii), (iii) and (iv) (d) (i), (ii) and (iv).

Last Answer : (d) (i), (ii) and (iv)

Methicillin resistant staphylococci do not respond to β-lactam antibiotics because: A. They produce a β-lactamase which destroys methicillin and related drugs B. They elaborate an amidase which destroys methicillin and related drugs C. They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics D. They are less permeable to β-lactam antibiotics

Description : Methicillin resistant staphylococci do not respond to β-lactam antibiotics because: A. They produce a β-lactamase which destroys methicillin and related drugs B. They elaborate an amidase which destroys ... low affinity for β-lactam antibiotics D. They are less permeable to β-lactam antibiotics

Last Answer : C. They have acquired penicillin binding protein which has low affinity for β-lactam antibioti

Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out tetracyclines C. Protein synthesizing apparatus of host cells has low affinity for tetracyclines D. Both ‘A’ and ‘C’ are correct

Description : Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out ... host cells has low affinity for tetracyclines D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently diminishes the diuretic action C. Potassium chloride in tablet formulation is likely to cause gut ulceration D. Both ‘A’ and ‘C’ are correct

Description : Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently ... is likely to cause gut ulceration D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

Difference in Gram positive and Gram negative bacteria is due to (a) cell wall (b) cell membrane (c) ribosome (d) cytoplasm.

Description : Difference in Gram positive and Gram negative bacteria is due to (a) cell wall (b) cell membrane (c) ribosome (d) cytoplasm.

Last Answer : (a) cell wall

Difference in Gram positive and Gram negative bacteria is due to (a) cell wall (b) cell membrane (c) ribosome (d) cytoplasm.

Description : Difference in Gram positive and Gram negative bacteria is due to (a) cell wall (b) cell membrane (c) ribosome (d) cytoplasm.

Last Answer : (a) cell wall

Which of the following is true about cell wall of gram-positive bacteria? A- It consists of multiple layers B- It is thicker than that associated with gram-negative bacteria C- It contains teichoic acids D- D.All of these

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Last Answer : D.All of these

Which of the following is true about cell wall of gram-positive bacteria? A-It consists of multiple layers B- It is thicker than that associated with gram-negative bacteria C- It contains teichoic acids D- All of these

Description : Which of the following is true about cell wall of gram-positive bacteria? A-It consists of multiple layers B- It is thicker than that associated with gram-negative bacteria C- It contains teichoic acids D- All of these

Last Answer : All of these

How do I make my balls penetrate deeper from the mound?

Description : How do I make my balls penetrate deeper from the mound?

Last Answer : If you have an orchard nearby, practice by throwing apples at trees. The splat sound is so satisfying.

This type of plough penetrate deeper than the conventional cultivation machinery and break up the layers of the soil. a. Chisel plough b. Disc plough d. None of the above

Description : This type of plough penetrate deeper than the conventional cultivation machinery and break up the layers of the soil. a. Chisel plough b. Disc plough d. None of the above

Last Answer : Ans - c. sub-soiler plough

The characteristic feature(s) of penicillin G is/are: A. It is unstable in aqueous solution B. Its antibacterial action is unaffected by pus and tissue fluids C. It is equally active against resting and multiplying bacteria D. Both ‘A’ and ‘B’ are correc

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When considering visible light cured composites, which of the following statements is incorrect? A. An air-inhibited layer is present superficially on the composite. B. The wavelength of the light which affects the initiator is in the range of 450 to 500 nanometers. C. All other things equal. The light generally penetrates deeper into a small-particle composite than it does into a microfilled composite. (smaller particles absorb more light) D. B and C E. All are true

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Last Answer : E. All are true

Which of the following is exposed on the outer surface of a gram-negative bacterium?A- O-antigen of lipopolysaccharide (LPS) B- Polysaccharide portion of lipoteichoic acid (LTA) C- Braun lipoprotein D- .Electron transport system components

Description : Which of the following is exposed on the outer surface of a gram-negative bacterium?A- O-antigen of lipopolysaccharide (LPS) B- Polysaccharide portion of lipoteichoic acid (LTA) C- Braun lipoprotein D- .Electron transport system components

Last Answer : O-antigen of lipopolysaccharide (LPS)

The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is preferred for the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias

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Last Answer : C. It is preferred for the treatment of fungal meningitis

The drug of choice for penicillinase producing Neisseria gonorrhoeae urethritis is: A. Amoxicillin B. Erythromycin C. Ceftriaxone D. Doxycycline

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Last Answer : C. Ceftriaxone

The last step in synthesis of peptidoglycan is A- attachment of a peptide to muramic acid B- attaching two amino acids to form a cross-link C- attachment of a portion of peptidoglycan to a membrane lipid D- binding of penicillin to a membrane protein

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Last Answer : attaching two amino acids to form a cross-link

The most important mechanism by which gram negative bacilli acquire chloramphenicol resistance is: A. Decreased permeability into the bacterial cell B. Acquisition of a plasmid encoded for chloramphenicol acetyl transferase C. Lowered affinity of the bacterial ribosome for chloramphenicol D. Switching over from ribosomal to mitochondrial protein synthesi

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Last Answer : B. Acquisition of a plasmid encoded for chloramphenicol acetyl transferas

Choose the correct statement in relation to treatment of urinary tract infection (UTI): A. Majority of UTIs are caused by gram positive bacteria B. Smaller doses of the antimicrobial agent suffice for lower UTI C. Fluid restriction is recommended so that the antimicrobial drug gets concentrated in urine D. Most acute UTIs are treated with a combination antimicrobial regimen

Description : Choose the correct statement in relation to treatment of urinary tract infection (UTI): A. Majority of UTIs are caused by gram positive bacteria B. Smaller doses of the antimicrobial agent ... drug gets concentrated in urine D. Most acute UTIs are treated with a combination antimicrobial regimen

Last Answer : B. Smaller doses of the antimicrobial agent suffice for lower UTI

An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will not develop any reaction when full dose of penicillin is injected C. He will not develop anaphylactic reaction when full dose of penicillin is injected D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Description : An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will ... He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Last Answer : D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected