Recent questions tagged analagesics

Description : Generally the earliest manifestation of salicylism is (a) Visual disturbance (b) Excitement (c) Hyperventillation (d) Tinnitus

Last Answer : Ans: D

Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is (a) Acid – base and electrolytc disturbances (b) Hypersensitivity and idiosyncratic reactions (c) Gastric mucosal damage (d) Salicylism

Last Answer : Ans: C

Description : Aspirin reduces fever by (a) Decreasing heat production in the body (b) Enhancing cutaneous blood flow (c) Inducing sweating (d) Both (b) and (c)

Last Answer : Ans: D

Description : Aspirin produces analgesia by (a) Preventing sensitization of peripheral pain receptors (b) Affecting gating of pain impulses at spinal level (c) Raising pain threshold at subcortical level (d) Both (a) and (b)

Last Answer : Ans: D

Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Last Answer : Ans: B

Description : Following mediators are involved in acute inflammation except (a) Histamine (b) Leukotrienes (c) Interferons (d) Bradykinin

Last Answer : Ans: C

Description : Lower dose of naloxone is required to (a) Antagonise the actions of nalorphine (b) Antagonise the actions of pentazocine (c) Precipitate withdrawal in mildly morphine dependent subjects (d) Precipitate withdrawal in highly morphine dependent subjects

Last Answer : Ans: D

Description : Which action of morphine is incompletely reversed by naloxone ? (a) Analgesia (b) Respiratory depression (c) Sedation (d) Miosis

Last Answer : Ans: C

Description : Pentazocine differs from morphine in that (a) It is inactive by the oral route (b) It does not produce physical dependence (c) It has a lower ceiling of analgesic effect (d) Its action is not blocked by naloxone

Last Answer : Ans: C

Description : Which of the following is an agonistantagonist type of opioid analgesic (a) Pethidine (b) Pentazocine (c) Fentanyl (d) Buprenorphine

Last Answer : Ans: B

Description : Morphine has high affinity for the following opioid receptor(s). (a) µ (Mu) (b) k (Kappa) (c) d (Delta) (d) All of the above

Last Answer : Ans: A

Description : An opioid analgesic is preferred over aspirin like analgesic in the following condition. (a) Acute gout (b) Burn (c) Toothache (d) Neuralgia

Last Answer : Ans: B

Description : Select the analgesic which acts through opioids as well as additional spinal monoaminergic mechanisms. (a) Tramadol (b) Ethoheptazine (c) Dextropropoxyphene (d) Alfentanil

Last Answer : Ans: A

Description : Which of the following opioid analgesics is similar to codeine in pharmacological profile but is less constipating ? (a) Methadone (b) Buprenorphine (c) Butorphanol (d) Dextropropoxyphene

Last Answer : Ans: D

Description : Which of the following opioids is more potent than morphine ? (a) Pethidine (b) Fentanyl (c) Dextropropoxyphene (d) Tramadol

Last Answer : Ans: B

Description : Morphine is contraindicated in head injury because (a) It does not relieve the pain of head injury (b) It can raise intracranial tension (c) It can cause constipation (d) It is liable to cause addiction

Last Answer : Ans: B

Description : Morphine dependence is characterized by (a) Marked drug seeking behavior (b) Physical dependence without psychic dependence (c) Physical as well as psychic dependence (d) Both (a) and (c)

Last Answer : Ans: D

Description : Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout (a) Indomethacin (b) Diclofenac (c) Piroxicam (d) Aspirin

Last Answer : Ans: D

Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine (a) Selegiline (b) Chlorgiline (c) Moclobemide (d) Tranylcypromine

Last Answer : Ans: A

Description : Instead of depressing, morphine stimulates (a) Vasomotor centre (b) Edinger westphal nucleus (c) Temperature regulating centre (d) Cough centre

Last Answer : Ans: B

Description : In man sedation caused by morphine is characterized by (a) Initial excitement (b) Little or no motor incoordination (c) Rise in seizure threshold (d) All of the above

Last Answer : Ans: B

Description : Morphine produces analgesia by acting at (a) Peripheral pain receptors (b) A spinal site (c) Suspraspinal sites (d) Both (b) and (c)

Last Answer : Ans: B

Description : Which of the following bones is affected more by glucocorticoid induced osteoporosis? (a) Femur (b) Humerus (c) Radius (d) Lumber vertebra

Last Answer : Ans: D

Description : The following adverse effect of corticosteroids is due to their mineralocorticoid action (a) Osteoporosis (b) Rise in blood pressure (c) Moon face (d) Increased susceptibility to infection

Last Answer : Ans: B

Description : Systemic corticosteroid therapy is not used routinely and is reserved only for severe cases of (a) Exfoliative dermatitis (b) Posterior uveitis (c) Acute rheumatic fever (d) Hodgkin’s disease

Last Answer : Ans: C

Description : For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamenthasone/dexamethasone because (a) They do not cause Na+ and water retention (b) They are more potent (c) They can be administered intravenously (d) They inhibit brain tumours

Last Answer : Ans: A

Description : Corticosteroid therapy is practically mandatory in the following condition. (a) Septic shock (b) Renal transplant (c) Rheumatoid arthritis (d) Ulcerative colitis

Last Answer : Ans: B

Description : Which of the following glucocorticoids has significant mineralocorticoid activity also ? (a) Hydrocortisone (b) Triamcinolone (c) Dexamethasone (d) Betamethasone

Last Answer : Ans: A

Description : Main effect of sulphinpyrazone in hyperuricaemia is (a) Suppress the symptoms (b) Promote the elimination of urate (c) prevent urate synthesis (d) All of the above

Last Answer : Ans: B

Description : Corticosteroids exert anti-inflammatory action by inhibiting the following enzyme (a) Cycloxygenase (b) Lipozygenase (c) Phospholipase - A (d) Phosphodiesterase

Last Answer : Ans: C

Description : Cervical priming with prostaglandin results in (a) Facilitation of sperm movement through cervical canal (b) Increased cervical tone (c) Softening of cervix (d) Increased cervical secretions

Last Answer : Ans: C

Description : The early pregnancy uterus is sensitive to the following oxytocic (a) Oxytocin (b) Methylergometrine (c) Prostaglandin F2a (d) Both (a) and (b)

Last Answer : Ans: C

Description : Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible

Last Answer : Ans: B

Description : The following prostanoid is a potent inducer of platelet aggregation (a) Prostacyclin (b) Prostaglandin E2 (c) Prostaglandin D2 (d) Thromboxane A2

Last Answer : Ans: D

Description : The prostanoid that consistently constricts blood vessels is (a) Prostaglandin E2 (b) Prostaglandin F2a (c) Thromboxane A2 (d) Prostacyclin

Last Answer : Ans: C

Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Last Answer : Ans: A

Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible

Last Answer : Ans: D

Description : Which of the following eicosanoids is generated through the lipozygenase pathway ? (a) Prostaglandin E2 (b) Thromboxane A2 (c) Prostacyclin (d) Leukotriene C4

Last Answer : Ans: D

Description : Autacoids differ from hormones in that (a) Autacoids are involved only in the causation of pathological states (b) Autacoids do not have a specific cell/ tissue of origin (c) Autacoids generally act locally at the site of generation and release (d) Both (b) and (c)

Last Answer : Ans: D

Description : Which of the following durgs is a monamine oxidase inhibitor, but is used to treat hypertension? (a) Tranylcypromine (Parnate) (b) Reserpine (c) Propranolol (Inderal) (d) Pargyline (Eutonyl) (e) Imipramine (Tofranil)

Last Answer : Ans: D

Description : Eicosanoids are a group of _____ carbon unsaturated fatty acids (a) 20 (b) 10 (c) 25 (d) 35

Last Answer : Ans: A

Description : A very common side effect of morphine is (a) Allergic response (b) Blood dyscrasias (c) Constipation (d) Liver damage (e) Visceral pain

Last Answer : Ans: C

Description : The greatest threat from morphine poisoning is (a) Renal shutdown (b) Paralysis of spinal cord (c) Respiratory depression (d) Cardiovascular collapse (e) None of the above

Last Answer : Ans: C

Description : Codeine acts as a cough sedative by (a) Producing mild nausea (b) Depressing bronchiolar secretions (c) Depressing pulmonary action (d) Depressing cough center (e) Paralyzing sensory nerves of bronchi

Last Answer : Ans: D

Description : Which type of patient is most likely to hypersensitive to aspirin? (a) Intrinsic asthamatic (b) Extrinsic asthamatic (c) Chronic bronchitic (d) Patient with viral injection (e) Both (c) and (d)

Last Answer : Ans: A

Description : Colchicine is used mainly to treat (a) Gout (b) Arthiritis (c) Diabetes (d) Carcinomas (e) High blood pressure

Last Answer : Ans: A

Description : The emetic action of morphine is due to (a) Irritation of gastrointestinal tract (b) Stimulation of cerebral cortex (c) Stimulation of medullary vomiting center (d) Stimulation of emetic chemoreceptor trigger zone (e) None of the above

Last Answer : Ans: D

Description : Cylcoocygenase-II specific inhibitors block the following (a) Production of cytoprotective prostaglandins (b) Tumor necrosis factor - a (c) Production of prostaglandins responsible for pain and inflammation

Last Answer : Ans: C

Description : Which of the following narcotics has the longest duration of effect? (a) Methadone (b) Controlled-release morphine (c) Levorphanol (d) Transdermal fentanyl (e) Dihydromorphone

Last Answer : Ans: D

Description : All of the following facts are true about non-steroidal anti-inflammatory drugs (NSAIDs) except (a) They are antipyretic (b) There is a celling effect to their analgesia (c) They can cause tolerance (d) They do not cause dependence (e) They are anti-inflammatory

Last Answer : Ans: C