Recent questions tagged pharmacokinetics

Description : 12. What is characteristic of the oral route? a) Fast onset of effect b) Absorption depends on GI tract secretion and motor function c) A drug reaches the blood passing the liver d) The sterilization of medicinal forms is obligatory

Last Answer : b) Absorption depends on GI tract secretion and motor function

Description : 11. Which route of drug administration is most likely to lead to the first-pass effect? a) Sublingual b) Oral c) Intravenous d) Intramuscular

Last Answer : b) Oral

Description : 10. Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized: a) Oral b) Transdermal c) Rectal d) Intraduodenal

Last Answer : c) Rectal

Description : 09. The reasons determing bioavailability are: a) Rheological parameters of blood b) Amount of a substance obtained orally and quantity of intakes c) Extent of absorption and hepatic first-pass effect d) Glomerular filtration rate

Last Answer : C

Description : 08. What does the term bioavailability mean? a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic ... following any route administration d) Amount of a substance in urine relative to the initial doze

Last Answer : C

Description : 07. What is implied by «active transport»? a) Transport of drugs trough a membrane by means of diffusion b) Transport without energy consumption c) Engulf of drug by a cell membrane with a new vesicle formation

Last Answer : d) Transport against concentration gradient

Description : 06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules

Last Answer : a) Low ability to penetrate through the cell membrane lipids

Description : 05. What kind of substances can’t permeate membranes by passive diffusion? a) Lipid-soluble b) Non-ionized substances c) Hydrophobic substances d) Hydrophilic substances 06. A hydrophilic medicinal agent

Last Answer : d) Hydrophilic substances

Description : 04. The main mechanism of most drugs absorption in GI tract is: a) Active transport (carrier-mediated diffusion) b) Filtration (aqueous diffusion) c) Endocytosis and exocytosis d) Passive diffusion (lipid diffusion)

Last Answer : PHARMACOKINETICS

Description : 03. What does “pharmacokinetics” include? a) Localization of drug action b) Mechanisms of drug action c) Excretion of substances d) Interaction of substances

Last Answer : c) Excretion of substances

Description : 02. What does “pharmacokinetics” include? a) Pharmacological effects of drugs b) Unwanted effects of drugs c) Chemical structure of a medicinal agent d) Distribution of drugs in the organism

Last Answer : d) Distribution of drugs in the organism

Description : 02. What does “pharmacokinetics” include? a) Complications of drug therapy b) Drug biotransformation in the organism c) Influence of drugs on metabolism processes d) Influence of drugs on genes

Last Answer : b) Drug biotransformation in the organism

Description : Pharmacokinetics is: a) The study of biological and therapeutic effects of drugs b) The study of absorption, distribution, metabolism and excretion of drugs c) The study of mechanisms of drug action d) The study of methods of new drug development

Last Answer : b) The study of absorption, distribution, metabolism and excretion of drugs