Which one of the following is true of IgE? 1) Is present in plasma in the same concentration as IgG 2) Is increased acutely in an asthmatic attack 3) Crosses the normal placenta 4) Is increased in the serum of atopic individuals 5) Is involved in type 2 hypersensitivity

Which one of the following is true of IgE? 1) Is present in plasma in the same concentration as IgG 2) Is increased acutely in an asthmatic attack 3) Crosses the normal placenta 4) Is increased in the serum of atopic individuals 5) Is involved in type 2 hypersensitivity
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Answers-4 IgG is the predominant form of immunoglobulin in plasma at a concentration around 10,000 times that of IgE. IgG crosses the placenta to confer immunity to the fetus but IgE does not. IgE is involved in arming mast cells and basophils. IgE causes mast cells to release vasoactive amines, such as histamine, producing an inflammatory response which can result in a type I hypersensitivity reaction. IgE is responsible for allergen-mediated diseases such as anaphylaxis, asthma and atopy. Total serum IgE is frequently increased in those with atopy but serum IgE does not rise acutely during an asthmatic attack.
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