Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : The following statement is true about misoprostol: A. It relieves peptic ulcer pain, but does not promote ulcer healing B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding ... side effects than H2 blockers D. It is the most effective drug for preventing ulcer relapse
Last Answer : B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding to H2 blockers
Description : Budesonide is a: A. Nonsteroidal antiinflammatory drug B. High ceiling diuretic C. Inhaled corticosteroid for asthma D. Contraceptive
Last Answer : C. Inhaled corticosteroid for asthma
Description : The following analgesic lacks antiinflammatory action: A. Paracetamol B. Ibuprofen C. Diclofenac sodium D. Piroxicam
Last Answer : A. Paracetamol
Description : Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop ... C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion
Last Answer : A. Preventing prostaglandin mediated intrarenal haemodynamic actions
Description : Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal ... . They do not worsen blood lipid profile D. They do not impair work performance
Last Answer : B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs
Description : The constellation of adverse effects associated with nonsteroidal antiinflammatory drugs include the following except: A. Sedation B. Gastric irritation C. Fluid retention D. Rashes
Last Answer : A. Sedation
Description : Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs): A. NSAIDs attenuate hypoglycaemic action of sulfonylureas B. NSAIDs potentiate antihypertensive action of ACE inhibitors C. ... D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Last Answer : D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Description : The nonsteroidal antiinflammatory drugs are more effective in migraine: A. Without aura B. With aura C. Than ergotamine D. When combined with propranolol
Last Answer : A. Without aura
Description : The isoenzyme cyclooxygenase-2 (COX-2) is expressed constitutively at the following site: A. Gastric mucosa B. Neutrophils C. Blood platelets D. Juxtaglomerular apparatus
Last Answer : D. Juxtaglomerular apparatus
Description : Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible
Last Answer : B. Platelets cannot synthesize fresh COX molecules
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely
Last Answer : D. COX-1 is constitutive while COX-2 is largely
Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase
Last Answer : C. Phospholipase-A
Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above
Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition
Description : Select the drug which inhibits cyclooxygenase irreversibly: A. Aspirin B. Mephenamic acid C. Naproxen D. Diclofenac
Last Answer : A. Aspirin
Description : The patient taking the following non-steroidal antiinflammatory drug should be cautioned not to drive motor vehicle: A. Celecoxib B. Indomethacin C. Naproxen D. Diclofenac sodium
Last Answer : B. Indomethacin
Description : Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam
Description : Select the drug which inhibits cyclooxygenase in the brain but not at peripheral sites of inflammation: A. Nimesulide B. Paracetamol C. Ketorolac D. Mephenamic acid
Last Answer : B. Paracetamol
Description : Three medications referred to as the ABC drugs' are currently the main pharmacological therapy for multiple sclerosis. Which of the following statements reflects information to be included in patient ... on an empty stomach. Glatiramer acetate is administed by intramuscular injection once a week.
Last Answer : a) Flu-like symptoms can be controlled with nonsteroidal antiinflammatory drugs (NSAIDs) and usually resolve after a few months of therapy. Seventy-five percent of patients taking one of the ... symptoms that can be controlled with NSAIDS and usually resolve after a few months of therapy.
Description : Nonsteroidal antiinflammatory drugs are more commonly used than colchicine in acute gout because: A. They are more effective B. They act more rapidly C. They have additional uricosuric action D. They are better tolerated
Last Answer : D. They are better tolerated
Description : Phenylbutazone should be used only in patients not responding to other nonsteroidal antiinflammatory drugs (NSAIDs) because: A. It has lower antiinflammatory efficacy than other NSAIDs B. It has potential ... It has weak analgesic action D. It alters the protein binding and metabolism of many drugs
Last Answer : B. It has potential to cause agranulocytosis
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible
Last Answer : Ans: D
Description : The following is/are true of mesalazine: A. It exerts mainly local antiinflammatory action in the lower gut B. It is a broad spectrum antidiarrhoeal drug C. It can be administered as a retention enema D. Both 'A' and 'C
Last Answer : D. Both 'A' and 'C
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : Which analgesic-antiinflammatory drug is more appropriate in musculo-skeletal disorder where pain is more prominent than inflammation: A. Ibuprofen B. Piroxicam C. Indomethacin D. Nimesulide
Last Answer : A. Ibuprofen
Description : Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation
Last Answer : D. Do not inhibit platelet aggregation
Description : For a patient of peptic ulcer, the safest nonopioid analgesic is: A. Celecoxib B. Diclofenac sodium C. Paracetamol D. Ibuprofen
Last Answer : C. Paracetamol
Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam
Last Answer : Ans: A
Description : Which of the following is a reversible inhibitor of platelet cyclooxygenase? (a) Alprostadil (b) Aspirin (c) Ibuprofen (d) LTC4 (e) Misoprostol
Last Answer : Ans: C
Description : Choose the correct statement about topotecan: A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks B. It is a cell cycle specific anticancer drug C. It is a COMT-inhibitor used in advanced parkinsonism D. Both 'A' and 'B' are correc
Last Answer : D. Both 'A' and 'B' are correct
Description : The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest: A. Busulfan B. Vincristine C. Cytarabine D. Procarbazine
Last Answer : B. Vincristine
Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects
Last Answer : D. It is unlikely to produce anti-androgenic side effects
Description : Select the drug which is an inhibitor of gastric mucosal proton pump: A. Carbenoxolone sodium B. Sucralfate C. Famotidine D. Lansoprazole
Last Answer : D. Lansoprazole
Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid
Last Answer : A. A HMG-CoA reductase inhibitor
Description : Choose the selective serotonin reuptake inhibitor that is less likely to inhibit CYP2D6 and CYP3A4 resulting in fewer drug interactions: A. Sertraline B. Paroxetine C. Fluoxetine D. Fluvoxamine
Last Answer : A. Sertraline
Description : The following drug of abuse is a hallucinogen: A. Cocaine B. Cannabis C. Heroin D. Methaqualone (p. 403) 31.1 Which of the following is a selective MAO-B inhibitor: A. Selegiline
Last Answer : B. Cannabis
Description : Select the anticonvulsant drug that acts as a GABAtransaminase inhibitor: A. Gabapentin B. Vigabatrin C. Lamotrig
Last Answer : B. Vigabatrin
Description : Select the correct statement about tibolone: A. It is an antiestrogen used for palliative treatment of carcinoma breast B. It is an estrogenic + progestational steroid used for hormone replacement ... for male pattern baldness D. It is a nonsteroidal estrogen used topically for senile vaginitis
Last Answer : B. It is an estrogenic + progestational steroid used for hormone replacement therapy in postmenopausal women
Description : The high virus selectivity of acyclovir is due to: A. Its preferential uptake by virus infected cells B. Need of virus specific enzyme for its conversion to the active metabolite C. Its action on ... reverse transcriptase which does not occur in noninfected cells D. Both A' and B' are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues
Last Answer : B. It is inducible
Description : Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin
Last Answer : A. Gentamicin
Description : The following purgative stimulates intestinal motility independent of its action on mucosal fluid dynamics: A. Castor oil B. Senna C. Docusates D. Sod.pot. tartrate
Last Answer : B. Senna
Description : Choose the preparation(s) of vitamin K that should not be injected in the newborn: A. Phytonadione B. Menadione C. Menadione sod.diphosphate D. Both ‘B’ and ‘C’
Last Answer : D. Both ‘B’ and ‘C’
Description : Tolerance does not develop to the vasodilator action of sodium nitroprusside while it develops to glyceryl trinitrate because: A. Intact sod. nitroprusside molecule acts like nitric oxide B. Enzymes which ... a long duration of action D. Sod. nitroprusside has additional K+ channel opening action
Last Answer : B. Enzymes which generate nitric oxide from nitroprusside are different
Description : Choose the correct statement about use of gold sod. thiomalate in rheumatoid arthritis: A. It affords more rapid symptomatic relief than NSAIDs B. The NSAIDs therapy is discontinued when it is ... D. It is used only in severe cases when other diseases modifying antirheumatic drugs have failed
Last Answer : D. It is used only in severe cases when other diseases modifying antirheumatic drugs have failed
Description : The selective COX-2 inhibitors have the following advantage(s) over the nonselective NSAIDs: A. They are less likely to cause gastric ulcers and their complications B. They are likely to be more ... in rheumatoid arthritis C. They are not likely to produce renal complications D. All of the above
Last Answer : A. They are less likely to cause gastric ulcers and their complications
Description : The following is true of clofazimine except: A. It is cidal to Mycobacterium leprae B. It has additional antiinflammatory property C. It has a very long elimination half life D. It discolours skin and sweat
Last Answer : A. It is cidal to Mycobacterium leprae
Description : Antiatherosclerotic effect of which class of hypolipidemic drugs may involve additional mechanisms like improved endothelial function, reduced LDL oxidation and antiinflammatory property: A. Bile acid sequestrant resins B. Statins C. Fibrates D. Nicotinic acid
Last Answer : B. Statins
Description : The most important mechanism of antiinflammatory action of glucocorticoids is: A. Inhibition of lysosomal enzymes B. Restriction of recruitment of inflammatory cells at the site of inflammation C. Antagonism of action of interleukins D. Suppression of complement function
Last Answer : B. Restriction of recruitment of inflammatory cells at the site of inflammation