LOL, you know that is a loaded question on a forum like this right? It depends on how you are running it. If it is the old mac version of IE, it probably won’t work, if you are talking about running it with Parallels or Crossover, or a similar program, it will only hurt your windows, not your mac. Unless there is a version of IE available I have yet to find for OS X, then it is hard to say. It might, it might not, most likely, not.