Robert De NiroTom Cruise.Brad PittEDIT: Well, based on amount of awards, Julie Andrews.EDIT 2: Dick Van DykeEDIT 3: Johnny Depp.EDIT 4: There is no 'most famous' actor or actress but the ones above are quite famous.There are numerous famous actors in the world. One of the most famous actors is George Clooney. Another one is Sandra Bullock.