DefinitionPrimary amyloidosis is a disorder in which protein fibers are deposited in tissues and organs, harming them.Alternative NamesAmyloid - primaryCauses, incidence, and risk factorsThe cause of primary amyloidosis is unknown, but the condition is related to abnormal production of antibodies by a type of immune cell called plasma cells.The symptoms depend on the organs affected by the deposits. These organs can include the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys.Primary amyloidosis can result in conditions that include:Carpal tunnel syndromeGastrointestinal reflux (GERD)Heart muscle damage (cardiomyopathy)Kidney failureMalabsorptionThe deposits build up in the affected organs, causing them to become stiff, which decre