DefinitionLambert-Eaton syndrome is a disorder in which faulty communication between nerves and muscles leads to muscle weakness .Alternative NamesMyasthenic syndrome; Eaton-Lambert syndromeCauses, incidence, and risk factorsLambert-Eaton syndrome occurs when nerves cells do not release enough of a chemical called acetylcholine, which transmits impulses between nerves and muscles.The result is muscle weakness and other symptoms similar to myasthenia gravis. However, as the muscles continue to contract, the chemical (acetylcholine) can build up in sufficient quantities for strength to get slightly better.Lambert-Eaton syndrome may be associated with cancers such as small-cell lung cancer and autoimmune disorders.SymptomsWeakness or loss of movement that varies in severity, such as: Difficul