DefinitionMalaise is a generalized feeling of discomfort, illness, or lack of well-being.Alternative NamesGeneral ill feelingConsiderationsMalaise is a symptom that can occur with almost any significant health condition. It may start slowly or quickly, depending on the type of disease.Fatigue occurs with malaise in many common diseases. Mailaise can be accompanied by a feeling of not having enough energy to accomplish usual activities.Common CausesThe following lists give examples of the diseases, conditions, and medications that can cause malaise.SHORT-TERM (ACUTE) INFECTIOUS DISEASEAcute bronchitis or pneumoniaAcute viral syndromeInfectious mononucleosis (EBV)InfluenzaLyme diseaseLONG-TERM (CHRONIC) INFECTIOUS DISEASEAIDSChronic active hepatitisDisease caused by parasitesTuberculosisHEAR