Description : Has regular ingestion of Benadryl caused you irritability and depression?
Last Answer : Yeah, they can definitely have effects on you the next day if you are sensitive to drugs. I never take one during the day unless I have hives or a bad insect bite or something. And just ½ of one will knock ... to the 25 mg ones. If they're not gel capsules, you can just cut the 50 mg ones in half.